AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON JANUARY 28, 2003 REGISTRATION NO. 333- ================================================================================ SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 EXELIXIS, INC. (Exact name of registrant as specified in its charter) Delaware 04-3257395 (State or other jurisdiction of (I.R.S. Employer incorporation or organization) Identification Number) 170 Harbor Way P.O. Box 511 South San Francisco, CA 94083 (650) 837-7000 (Address of principal executive offices) 2000 EQUITY INCENTIVE PLAN 2000 EMPLOYEE STOCK PURCHASE PLAN 2000 NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN (Full title of the plans) Glen Y. Sato Chief Financial Officer Exelixis, Inc. 170 Harbor Way P.O. Box 511 South San Francisco, CA 94083 (650) 837-7000 (Name, address, including zip code, and telephone number, including area code,of agent for service) Copies to: ROBERT L. JONES, ESQ. COOLEY GODWARD LLP FIVE PALO ALTO SQUARE 3000 EL CAMINO REAL PALO ALTO, CALIFORNIA 94306 CALCULATION OF REGISTRATION FEE ======================================================================================================================= PROPOSED MAXIMUM TITLE OF CLASS OF SECURITIES AMOUNT TO BE PROPOSED MAXIMUM OFFERING AGGREGATE OFFERING AMOUNT OF TO BE REGISTERED REGISTERED(1) PRICE PER SHARE (2) PRICE (2) REGISTRATION FEE ------------------------------ ----------------- --------------------------- -------------------- ----------------- ------------------------------ ----------------- --------------------------- -------------------- ----------------- Stock Options and Common Stock 4,853,009 shares $ 6.96 $ 33,776,924.64 $ 3,107.48 (par value $.001) ======================================================================================================================= (1) This Registration Statement shall cover any additional shares of common stock that become issuable under the 2000 Equity Incentive Plan, 2000 Non-Employee Directors' Stock Option Plan and 2000 Employee Stock Purchase Plan set forth herein by reason of any stock dividend, stock split, recapitalization or any other similar transaction without receipt of consideration which results in an increase in the number of shares of the Registrant's outstanding common stock. (2) Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(c) and (h)(1) under the Securities Act of 1933, as amended (the "Act"). The offering price per share and aggregate offering price for the unissued stock options and common stock are based upon the average of the high and low prices of the Registrant's common stock as reported on the Nasdaq National Market System on January 27, 2003. The following chart illustrates the calculation of the registration fee: TITLE OF SHARES NUMBER OF SHARES OFFERING PRICE PER AGGREGATE OFFERING SHARE PRICE Shares issuable pursuant to unissued stock options 3,849,981 $ 6.96 $ 26,795,867.76 pursuant to the 2000 Equity Incentive Plan Shares issuable pursuant to unissued stock options 501,514 $ 6.96 $ 3,490,537.44 pursuant to the 2000 Non-Employee Directors' Stock Option Plan Shares issuable pursuant to the 2000 Employee Stock Purchase Plan 501,514 $ 6.96 $ 3,490,537.44 Proposed Maximum Aggregate Offering Price $ 33,776,924.64 Approximate date of commencement of proposed sale to the public: as soon as practicable after this Registration Statement becomes effective. EXPLANATORY NOTE This Registration Statement on Form S-8 is being filed for the purpose of registering an additional: (i) 3,849,981 shares of the Registrant's common stock to be issued pursuant to the Registrant's 2000 Equity Incentive Plan; (ii) 501,514 shares of the Registrant's common stock to be issued pursuant to the Registrant's 2000 Non-Employee Directors' Stock Option Plan; and (iii) 501,514 shares of the Registrant's common stock to be issued pursuant to the Registrant's 2000 Employee Stock Purchase Plan. INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE The contents of the Registration Statements on Form S-8 (relating to the 2000 Equity Incentive Plan, 2000 Non-Employee Directors' Stock Option Plan and 2000 Employee Stock Purchase Plan) File Nos. 333-35862, 333-57026 and 333-82722 previously filed with the SEC on April 28, 2000, March 14, 2001 and February 14, 2002, respectively, are incorporated by reference herein. ITEM 8. EXHIBITS EXHIBIT NUMBER DESCRIPTION 4.1* Amended and Restated Certificate of Incorporation of the Company. 4.2* Restated Bylaws of the Company. 5.1 Opinion of Cooley Godward llp. 23.1 Consent of Ernst & Young LLP, Independent Auditors. 23.2 Consent of Independent Accountants. 23.3 Consent of Cooley Godward llp is contained in Exhibit 5.1 to this Registration Statement. 24.1 Power of Attorney is contained on the signature pages to this Registration Statement. 99.1* 2000 Equity Incentive Plan. 99.2* 2000 Employee Stock Purchase Plan. 99.3* 2000 Non-Employee Directors' Stock Option Plan. 99.4 Selected Financial Data Additional Disclosure for FASB No. 142. ________________________ *Incorporated by reference to the Company's Registration Statement on Form S-1, as amended (File No.333-96335), originally filed with the SEC on February 7, 2000. SIGNATURES Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of South San Francisco, State of California, on January 28, 2003. EXELIXIS, INC. By: /s/ George A. Scangos ------------------------- George A. Scangos, Ph.D. President and Chief Executive Officer POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints George A. Scangos and Glen Y. Sato, and each or any one of them, his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated. SIGNATURE TITLE DATE ------------------------------ ---------------------------------- ------------------ /s/ George A. Scangos President, Chief Executive January 28, 2003 ------------------------------ Officer and Director George A. Scangos, Ph.D. (Principal Executive Officer) /s/ Glen Y. Sato Chief Financial Officer January 28, 2003 ------------------------------ (Principal Financial and Glen Y. Sato Accounting Officer) /s/ Stelios Papadopoulos Chairman of the Board of ------------------------------- Directors January 28, 2003 Stelios Papadopoulos, Ph.D. /s/ Charles Cohen ------------------------------ Director January 28, 2003 Charles Cohen, Ph.D. /s/ Geoffrey Duyk Director January 28, 2003 ------------------------------- Geoffrey Duyk, M.D., Ph.D. /s/ Jason Fisherman Director January 28, 2003 ------------------------------- Jason S. Fisherman, M.D. /s/ Jean-Francois Formela Director January 28, 2003 ------------------------------- Jean-Francois Formela, M.D. /s/ Vincent T. Marchesi Director January 28, 2003 ------------------------------- Vincent T. Marchesi, Ph.D. /s/ Peter Stadler Director January 28, 2003 ------------------------------- Peter Stadler, Ph.D. /s/ Lance Willsey ------------------------------ Director January 28, 2003 Lance Willsey, M.D. EXHIBIT INDEX EXHIBIT NUMBER DESCRIPTION 4.1* Amended and Restated Certificate of Incorporation of the Company. 4.2* Restated Bylaws of the Company. 5.1 Opinion of Cooley Godward llp. 23.1 Consent of Ernst & Young LLP, Independent Auditors. 23.2 Consent of Independent Accountants. 23.3 Consent of Cooley Godward llp is contained in Exhibit 5.1 to this Registration Statement. 24.1 Power of Attorney is contained on the signature pages to this Registration Statement. 99.1* 2000 Equity Incentive Plan. 99.2* 2000 Employee Stock Purchase Plan. 99.3* 2000 Non-Employee Directors' Stock Option Plan. 99.4 Selected Financial Data Additional Disclosure for FASB No. 142. ________________________ *Incorporated by reference to the Company's Registration Statement on Form S-1, as amended (File No.333-96335), originally filed with the SEC on February 7, 2000.