Client Id: 77 JANUARY 03, 2019 / 1:00PM, CELG - Bristol-Myers Squibb Co to Acquire Celgene Corp M&A
Call the areas that we're looking at, exploring the immune system, understanding what underlies both the immuno reaction to cancer and immunesystem (inaudible) in autoimmune disease. These are fundamental similarities between 2 companies, and
I think that gives us a remarkableopportunity for a complementary approach in this setting. There are a couple of things. I mean, when I look at Celgene, I look at a company thathas completely transformed the way patients with myeloma are
treated. Very much the way we have completely transformed the way patientswith melanoma and renal cell cancer have been treated. When you think of how both of these companies have made an enormous contributionto human health over the past
decade, they're very similar in those 2 respects. And what I'm struck by when I look at Celgene is how that pathcontinues as we move forward. So yes, the image are extremely important, but when you look at what's behind the image, the
understanding ofthe science of what drives the response to Revlimid and Pomalyst, understanding that protein homeostasis within the cell is really a crucial part ofhow we get our antitumor responses, with the CELMoDs which are being developed
by Celgene, have extreme potential, not just in diseases, likemyeloma or other hematologic malignancies, but potentially even having applicability into solid tumors. When one looks at the areas of cellulartherapy, you are looking at the finest
company in the world in terms of their cellular therapy abilities, and so that again also adds to this. And then,finally, in immuno science, you look at a drug like ozanimod and you look at the potential of ozanimod as -- and our drug TYK2 as
we look forward,to really expand the ability of oral agents to make a big difference in patients with autoimmune disease. We have not been in the MS space before,but in multiple sclerosis, the ozanimod offers great potential. And then both
ozanimod and TYK2 offer great potential for patients with inflammatorybowel disease down the road as well. And then when one looks deeper in the pipeline, you see that, together, we have about 60 agents, which arein development, which we
believe have the potential to offer value in the late phase of this, in the 2026 to 2029 framework. So you see alignmentaround strategy, you see alignment around the commitment to translational science and fundamental biology. And again, I
think this has characterizedboth companies as we move forward. Rupert? S. J. Rupert Vessey - Celgene Corporation - President of Research & Early Development Yes. Tom, I think you've covered it extremely well. So, I mean, clearly, we
talked a lot about the 5 near-term products that Celgene is bringing tothe table in this transaction. They're visible, most of you know, a lot about those and they're real and they're on their path. From a Celgene pointof view, looking further
back, we have a whole campaign around BCMA for the treatment of myeloma. And we're the leaders in this, we've got theleading cellular therapy. We have a differentiated bispecific antibody, which is moving along very nicely in the clinic. We
also have an antibodydrug conjugate, which is just about to be filed as an IND. So we've got all approaches to that extremely highly validated target, which positionsthat part of the pipeline extremely well. Tom mentioned the cellular therapies
and I talked about those earlier, so I won't go back over thosecomments. But the other piece that I think is really worth highlighting is the protein homeostasis platform. We did a deep dive on this a couple ofyears ago for our investor
community. That information is available, should you like to go back and look at that. And things have advanceddramatically since then. Celgene is the leader in understanding how to use the cerebellum pathway to degrade critical target
proteins. And we'vebeen at the forefront of understanding the mechanism of action of these drugs. We have several cerebellum-modulating drugs that are now inthe clinic. They're for myeloma, they're for AML, they're for lymphoma. They're
advancing extremely well. And behind that, there is a significanteffort to move this into solid tumors. We're also able to leverage this technology for other strategies of protein degradation, and what this doesfor you is open up the
opportunity to go after drug targets that are completely inaccessible to standard modalities, such as conventional smallmolecule chemistry or biologics. I think this part of the portfolio will be extremely complementary to what BMS has in the
pipeline. And I think youcan look forward to a lot of extremely important combinatorial studies from the extensive pipeline that we now have. Operator We have a question from John Boris with SunTrust. John Thomas Boris - SunTrust Robinson
Humphrey, Inc., Research Division - MD Congratulations on the deal. The first just has to do with a lot of e-mails we've gotten on the contingent value rights for the 3 assets. In fact, oneof the assets with blue is the bb2121 is obviously in
a partnership. Those that are partnered to -- is there any impact on that partnership from thetransaction? And then on those 3 drugs, can you talk about probability of success, some of the clinical data filing timelines and approval? Can
yougive some specific -- more specific information on that? And then secondly, on the breakup fee, is there any breakup fee should you decide not togo through with the transaction? And then lastly, did Celgene entertain any other competitive
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