Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  KUCHERLAPATI RAJU S
 2. Date of Event Requiring Statement (Month/Day/Year)
03/11/2010		 3. Issuer Name and Ticker or Trading Symbol
AVEO PHARMACEUTICALS INC [AVEO]
(Last)
(First)
(Middle)
C/O AVEO PHARMACEUTICALS, INC., 75 SIDNEY STREET		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

CAMBRIDGE, MA 02139		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 45,511
D
 
Common Stock 19,053
I
Held as custodian (1)
Common Stock 42,078
I
Held c/f David Kucherlapati. (2)
Common Stock 3,773
I
Held as Custodian FBO David Kucherlapati UTMA MA until age 21 (3)
Common Stock 50,000
I
Held by Raju Kucherlapati Grantor Retained Annuity Trust No. 1 (4)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy)   (5) 09/26/2018 Common Stock 1,251 $ 6.88 D  
Stock Option (right to buy)   (6) 06/17/2019 Common Stock 3,334 $ 8.72 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
KUCHERLAPATI RAJU S
C/O AVEO PHARMACEUTICALS, INC.
75 SIDNEY STREET
CAMBRIDGE, MA 02139		   X      

Signatures

/s/ Raju Kucherlapati 03/11/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Held as custodian for David Kucherlapati under the Massachusetts Uniform Transfers to Minors Act. Dr. Kucherlapati disclaims beneficial ownership over all such shares, except to the extent of his pecuniary interest therein.
(2) Dr. Kucherlapati disclaims beneficial ownership over all shares held c/f David Kucherlapati, except to the extent of his pecuniary interest therein.
(3) Held as Custodian FBO David Kucherlapati UTMA MA until age 21. Dr. Kucherlapati disclaims beneficial ownership over all such shares, except to the extent of his pecuniary interest therein.
(4) Held by Raju Kucherlapati Grantor Retained Annuity Trust No. 1, over which Dr. Kucherlapati is the trustee and exercises sole voting and investment power over the shares of record. Dr. Kucherlapati disclaims beneficial ownership over all such shares, except to the extent of his pecuniary interest therein.
(5) This option first became exercisable on September 1, 2008 and vests over a two-year period in equal monthly installments.
(6) This option first became exercisable on July 31, 2009 and vests over a one-year period in equal monthly installments.

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