FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0287 Expires: January 31, 2005 Estimated average burden hours per response... 0.5

(Print or Type Responses)

1. Name and Address of Reporting Person * Plio Ltd   2. Issuer Name and Ticker or Trading Symbol Karyopharm Therapeutics Inc. [KPTI] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director __X__ 10% Owner _____ Officer (give title below) __X__ Other (specify below) Former 10% Owner (exit filing) (Last) (First) (Middle) SIMOU MENARDOU 8,, RIA COURT 8, OFFICE 101 3. Date of Earliest Transaction (Month/Day/Year) 07/23/2014 (Street) 6015 LARNACA, G4  4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) ___ Form filed by One Reporting Person _X_ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price COMMON STOCK 07/23/2014   S   500,000 A $ 35.5437 2,693,473 (1) D (1) (2) (3)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
	Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.		SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Plio Ltd SIMOU MENARDOU 8, RIA COURT 8, OFFICE 101 6015 LARNACA, G4		X		Former 10% Owner (exit filing)
Czernik Marcin SIMOU MENARDOU 8, RIA COURT 8, OFFICE 101 6015 LARNACA, G4		X
Hadjimichael Andreas SIMOU MENARDOU 8, RIA COURT 8, OFFICE 101 6015 LARNACA, G4		X
Hadjimichael Amalia SIMOU MENARDOU 8, RIA COURT 8, OFFICE 101 6015 LARNACA, G4		X
Jankilevitsch Gregory CHALET LE REFUGE CHEMIN DE JOLIMONT 18 VILLARS-SUR-OLLON, V8 CH-1884				Former 10% Owner (exit filing)

Signatures

/s/ Plio Limited, by /s/ Simon Prisk, as attorney-in fact by power of attorney		07/25/2014
**Signature of Reporting Person		Date
/s/ Marcin Czernik, by /s/ Simon Prisk, as attorney-in fact by power of attorney		07/25/2014
**Signature of Reporting Person		Date
/s/ Andreas Hadjimichael, by /s/ Simon Prisk, as attorney-in fact by power of attorney		07/25/2014
**Signature of Reporting Person		Date
/s/ Amalia Hadjimichael, by /s/ Simon Prisk, as attorney-in fact by power of attorney		07/25/2014
**Signature of Reporting Person		Date
/s/ Gregory Jankilevitsch, by /s/ Simon Prisk, as attorney-in fact by power of attorney		07/25/2014
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Shares of Common Stock are owned directly by Plio Limited ("Plio"). Plio's directors, Marcin Czernik, Andreas Hadjimichael and Amalia Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Plio. Gregory Jankilevitsch , the sole shareholder of Plio, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Plio. The shares owned by Plio do not include the 10,258,079 shares of the issuer's Common Stock held by Chione Limited, which has the same directors as Plio.
(2)	Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Each reporting person disclaims beneficial ownership of the securities covered by this statement, except to the extent of the pecuniary interest of such person in such securities.
(3)	Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.
Remarks: Exhibit Index Exhibit 24.1 - Power of Attorney, dated November 5. 2013, made by Marcin Czernik and Plio Limited in favor of Simon Prisk (previously filed) Exhibit 24.2 - Power of Attorney, dated November 5. 2013, made by Andreas Hadjimichael and Plio Limited in favor of Simon Prisk (previouslyfiled) Exhibit 24.3 - Power of Attorney, dated November 5. 2013, made by Amalia Hadjimichael and Plio Limited in favor of Simon Prisk (previously filed) Exhibit 24.4 - Power of Attorney, dated November 5. 2013, made by Gregory Jankilevitsch in favor of Simon Prisk (previously filed) Exhibit 99.1 - Joint Filer Information (previously filed) Exhibit 99.2 - Joint Filing Agreement (previously filed) All previously filed Exhibits were filed with the Form 3 of the reporting persons, filed on November 8, 2013, except that Exhibit 99.1 was filed with the Form 4 of the reporting persons filed on November 14, 2013.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.