UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                  SCHEDULE 13D
                   Under the Securities Exchange Act of 1934
                                (Amendment No. 2)*


                              SPECTRUM PHARMACEUTICALS, INC.
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                                (Name of Issuer)

                    Common Stock, par value $0.001 per share
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                         (Title of Class of Securities)

                                   84763A108
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                                 (CUSIP Number)

Mitchell D. Kaye, Manager                            with a copy to:
Xmark Asset Management, LLC                          Steven E. Siesser, Esq.
301 Tresser Boulevard                                Lowenstein Sandler PC
Suite 1320                                           65 Livingston Avenue
Stamford, CT 06901                                   Roseland, New Jersey  07068
(203) 653-2500                                       (973) 597-2506
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                 (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                 December 31, 2004
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             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule l3G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule  because of Sections 240.13d-1(e),  240.13d-1(f) or 240.13d-1(g), check
the following box. [ ]

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits.  See Section 240.13d-7 for other
parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).




Cusip No.         84763A108    
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1.  Names of Reporting Persons.  I.R.S. Identification Nos. of above persons 
   (entities only):
                       Xmark Asset Management, LLC
                               13-3954392
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2.  Check the Appropriate Box if a Member of a Group (See Instructions):
         (a)                  Not 
         (b)               Applicable
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3.  SEC Use Only
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4.  Source of Funds (See Instructions):  WC
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5.  Check  if  Disclosure of  Legal Proceedings  Is Required  Pursuant  to Items
    2(d) or 2(e):                 Not Applicable
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6.  Citizenship or Place of Organization:   New York, United States

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    Number of                      7. Sole Voting Power:                  *
                                     -------------------------------------------
    Shares Beneficially            8. Shared Voting Power:                *
                                     -------------------------------------------
    Owned by
    Each Reporting                 9. Sole Dispositive Power:             *
                                      ------------------------------------------
    Person With                    10. Shared Dispositive Power:          *
                                      ------------------------------------------
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11. Aggregate Amount Beneficially Owned by Each Reporting Person:  1,143,789*
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12. Check if  the  Aggregate  Amount in  Row (11) Excludes  Certain  Shares (See
    Instructions):               Not Applicable

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13. Percent of Class Represented by Amount in Row (11):   7.4%*
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14. Type of Reporting Person (See Instructions):   IA


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* The  reporting  person is Xmark  Asset  Management,  LLC  ("XAM"),  a New York
limited liability company.  XAM's interest in the securities  reported herein is
limited to its  pecuniary  interest,  if any,  in Xmark Fund,  L.P.,  a Delaware
limited  partnership  ("Xmark  LP"),  and Xmark  Fund,  Ltd.,  a Cayman  Islands
exempted company ("Xmark Ltd").

Xmark LP is the holder of: (i) 561,145  shares (the "Xmark LP Shares") of Common
Stock,   par  value  $0.001  per  share  (the  "Common   Stock"),   of  Spectrum
Pharmaceuticals,  Inc., a Delaware  corporation (the  "Company");  (ii) warrants
(the "2003 Xmark LP Warrants") which,  subject to certain exercise  restrictions
contained  therein,  entitle  Xmark LP to purchase an aggregate of up to 168,000
shares of Common Stock at an exercise  price of $6.50 per share (the "2003 Xmark
LP Warrant Shares"),  which exercise price is subject to adjustment as set forth
in the 2003 Xmark LP Warrants;  (iii)  warrants  (the "2004 Xmark LP  Warrants")
which, subject to certain exercise restrictions contained therein, entitle Xmark
LP to  purchase  an  aggregate  of up to 53,666  shares  of  Common  Stock at an
exercise price of $10.00 per share (the "2004 Xmark LP Warrant  Shares"),  which
exercise  price is  subject  to  adjustment  as set  forth in the 2004  Xmark LP
Warrants;  and (iv) 108 call options  exercisable  into 10,800  shares of Common
Stock at an exercise price of $10.00 per share.

Xmark Ltd is the holder of: (i) 561,144  shares of Common  Stock (the "Xmark Ltd
Shares," and together  with the Xmark LP Shares,  the  "Shares");  (ii) warrants
(the "2003 Xmark Ltd  Warrants,"  and together  with the 2003 Xmark LP Warrants,
the "2003 Warrants") which, subject to certain exercise  restrictions  contained
therein,  entitle Xmark Ltd to purchase an aggregate of up to 252,000  shares of
Common  Stock at an  exercise  price of $6.50 per  share  (the  "2003  Xmark Ltd
Warrant  Shares,"  and  together  the 2003  Xmark LP Warrant  Shares,  the "2003
Warrant Shares"),  which exercise price is subject to adjustment as set forth in
the 2003 Xmark Ltd Warrants;  (iii) warrants which,  subject to certain exercise
restrictions contained therein, entitle Xmark Ltd to purchase an aggregate of up
to 51,335  shares of Common Stock at an exercise  price of $10.00 per share (the
"2004 Xmark Ltd Warrant  Shares," and together the 2004 Xmark LP Warrant Shares,
the "2004 Warrant Shares"), which exercise price is subject to adjustment as set
forth in the 2004 Xmark Ltd Warrants; and (iv) 107 call options exercisable into
10,700 shares of Common Stock at an exercise price of $10.00 per share.




The 2003 Warrants and the 2004 Warrants each provide that in no event shall such
warrants  be  exercisable  for  shares of Common  Stock to the  extent  that the
issuance of Common Stock thereunder  would result in the "beneficial  ownership"
(as defined in Section 13(d) of the Securities Exchange Act of 1934, as amended,
and Regulations  13D-G  thereunder) by Xmark LP, Xmark Ltd, or their affiliates,
of more than 4.95% and 4.99%,  respectively,  of the Common Stock (the "Issuance
Limitation"). The Issuance Limitation may not be waived.

XAM serves as  investment  manager  for each of Xmark LP and Xmark Ltd.  In such
capacity,  XAM  possesses  the power to vote and direct the  disposition  of all
securities  held by Xmark LP and Xmark Ltd.  Thus,  as of April 21, 2005 for the
purposes  of Reg.  Section  240.13d-3,  XAM may be  deemed to  beneficially  own
1,143,789  shares of Common Stock, or 7.4% of the Common Stock deemed issued and
outstanding as of that date.





Item 5.   Interest in Securities of the Issuer.
          ------------------------------------ 

          Based upon information provided by the Company,  there were 15,352,949
shares of Common Stock issued and  outstanding as of April 18, 2005. As of April
21, 2005,  Xmark LP and Xmark Ltd  beneficially  own 1,143,789  shares of Common
Stock.

          As of April 21, 2005,  Xmark LP is the holder of (i) 561,145 shares of
Common Stock of the Company,  (ii) warrants which,  subject to certain  exercise
restrictions contained therein,  entitle Xmark LP to purchase up to an aggregate
of 168,000  shares of Common Stock at an exercise  price of $6.50 per share (the
"2003 Xmark LP Warrants"),  which exercise price is subject to adjustment as set
forth in the 2003 Xmark LP Warrants,  (iii) warrants  which,  subject to certain
exercise restrictions  contained therein,  entitle Xmark LP to purchase up to an
aggregate of 53,666  shares of Common  Stock at an exercise  price of $10.00 per
share  (the  "2004  Xmark LP  Warrants",  and  together  with the 2003  Xmark LP
Warrants,  the  "Xmark  LP  Warrants"),  which  exercise  price  is  subject  to
adjustment as set forth in the 2004 Xmark LP Warrants, and (iv) 108 call options
exercisable  into 10,800  shares of Common Stock at an exercise  price of $10.00
per share.  Xmark Ltd is the holder of (i) 561,144 shares of Common Stock,  (ii)
warrants which,  subject to certain  exercise  restrictions  contained  therein,
entitle  Xmark Ltd to purchase up to an  aggregate  of 252,000  shares of Common
Stock at an exercise  price of $6.50 per share (the "2003 Xmark Ltd  Warrants"),
which exercise price is subject to adjustment as set forth in the 2003 Xmark Ltd
Warrants,  (iii)  warrants  which,  subject  to  certain  exercise  restrictions
contained  therein,  entitle  Xmark Ltd to purchase up to an aggregate of 51,335
shares of Common Stock at an exercise price of $10.00 per share (the "2004 Xmark
Ltd  Warrants",  and together with the 2003 Xmark Ltd  Warrants,  the "Xmark Ltd
Warrants"),  which  exercise  price is subject to adjustment as set forth in the
2004 Xmark Ltd  Warrants,  and (iv) 107 call  options  exercisable  into  10,700
shares of Common Stock at an exercise price of $10.00 per share.

          The 2003  Warrants and the 2004 Warrants each provide that in no event
shall such warrants be exercisable for shares of Common Stock to the extent that
the  issuance  of  Common  Stock  thereunder  would  result  in the  "beneficial
ownership" (as defined in Section 13(d) of the Securities  Exchange Act of 1934,
as amended,  and Regulations  13D-G thereunder) by Xmark LP, Xmark Ltd, or their
affiliates, of more than 4.95% and 4.99%, respectively, of the Common Stock (the
"Issuance  Limitation").  The Issuance Limitation may not be waived. Thus, as of
April 21, 2005, for the purposes of Reg. Section 240.13d-3, XAM may be deemed to
beneficially  own 1,143,789  shares of Common Stock, or 7.4% of the Common Stock
deemed issued and outstanding as of that date.

          The following table details the transactions effected since the filing
of Amendment No. 1 to the Schedule 13D, in Common Stock, by XAM or any person or
entity  controlled by XAM or any person or entity for which XAM possesses voting
or investment control over the securities thereof (each of which was effected in
an ordinary brokerage transaction).


                                   I.  Xmark LP
                                   ------------

                                   (Purchases)

     Date                          Quantity                Price Per Share
     ----                          --------                ---------------

   11/23/04                           2,471                     $5.86
   01/21/05                          10,000                     $6.24
   01/24/05                           7,500                     $6.24
   01/24/05                           2,350                     $6.14
   01/25/05                           8,200                     $6.10
   01/25/05                          12,500                     $6.08
   01/26/05                           5,000                     $6.05
   02/11/05                          12,500                     $6.16
   02/11/05                           8,340                     $6.14
   02/14/05                           5,000                     $6.15
   02/15/05                           2,500                     $6.07
   02/17/05                           7,500                     $6.06
   02/22/05                             150                     $6.05
   02/23/05                           5,000                     $6.10
   02/24/05                           5,100                     $6.11
   02/25/05                           3,130                     $6.16
   02/28/05                           2,500                     $6.39
   03/02/05                           4,000                     $7.04
   03/04/05                           2,000                     $7.26
   03/07/05                             875                     $7.20
   03/08/05                           5,000                     $7.17
   03/08/05                           2,600                     $7.03
   03/09/05                           7,800                     $6.86
   03/14/05                           8,700                     $6.87
   03/15/05                          22,600                     $6.76
   03/18/05                           2,500                     $6.35
   03/21/05                           2,500                     $6.14
   03/23/05                           1,500                     $6.10
   03/24/05                             300                     $6.06
   03/29/05                           3,500                     $5.96
   03/30/05                           4,250                     $5.95
   03/31/05                           1,000                     $5.96
   04/04/05                             750                     $6.05
   04/06/05                           5,000                     $6.03
   04/11/05                              50                     $5.97
   04/15/05                           1,400                     $6.06
   04/18/05                          25,000                     $6.00
   04/20/05                             500                     $5.95
   04/21/05                             650                     $6.00

                                     (Sales)


     Date                          Quantity                Price Per Share
     ----                          --------                ---------------

   12/16/04                          10,132                     $5.93
   12/28/04                          19,522                     $5.95
   12/29/04                           3,792                     $6.36
   12/31/04                          33,459                     $6.62
   01/03/05                           2,591                     $6.43
   01/10/05                           2,500                     $7.05
   04/01/05                              50                     $6.45





                                  II.  Xmark Ltd
                                  --------------

                                   (Purchases)

     Date                          Quantity                Price Per Share
     ----                          --------                ---------------

   11/23/04                           2,529                     $5.86
   01/21/05                          10,000                     $6.24
   01/24/05                           7,500                     $6.24
   01/24/05                           2,350                     $6.14
   01/25/05                           8,200                     $6.10
   01/25/05                          12,500                     $6.08
   01/26/05                           5,000                     $6.05
   02/11/05                          12,500                     $6.16
   02/11/05                           8,339                     $6.14
   02/14/05                           5,000                     $6.15
   02/15/05                           2,500                     $6.07
   02/17/05                           7,500                     $6.06
   02/22/05                             150                     $6.05
   02/23/05                           5,000                     $6.10
   02/24/05                           5,100                     $6.11
   02/25/05                           3,130                     $6.16
   02/28/05                           2,500                     $6.39
   03/02/05                           4,000                     $7.04
   03/04/05                           2,000                     $7.26
   03/07/05                             875                     $7.20
   03/08/05                           5,000                     $7.17
   03/08/05                           2,600                     $7.03
   03/09/05                           7,800                     $6.86
   03/14/05                           8,700                     $6.87
   03/15/05                          22,600                     $6.76
   03/18/05                           2,500                     $6.35
   03/21/05                           2,500                     $6.14
   03/23/05                           1,500                     $6.10
   03/24/05                             300                     $6.06
   03/29/05                           3,500                     $5.96
   03/30/05                           4,250                     $5.95
   03/31/05                           1,000                     $5.96
   04/04/05                             750                     $6.05
   04/06/05                           5,000                     $6.03
   04/11/05                              50                     $5.97
   04/15/05                           1,400                     $6.06
   04/18/05                          25,000                     $6.00
   04/20/05                             500                     $5.95
   04/21/05                             650                     $6.00






                                     (Sales)

     Date                          Quantity                Price Per Share
     ----                          --------                ---------------

   12/16/04                          10,368                     $5.93
   12/28/04                          19,978                     $5.95
   12/29/04                          13,235                     $6.36
   12/31/04                          34,241                     $6.62
   01/03/05                           1,809                     $6.43
   01/10/05                           2,500                     $7.05
   04/01/05                              50                     $6.45


In addition to the  transactions  enumerated in the tables above, the only other
transactions effected since the filing of Amendment No. 1 to the Schedule 13D in
Common Stock, or securities  convertible  into,  exercisable for or exchangeable
for Common Stock, by XAM or any person or entity controlled by XAM or any person
or  entity  for which  XAM  possesses  voting  or  investment  control  over the
securities  thereof,  was the March 10, 2005 purchase by Xmark LP and Xmark Ltd,
respectively,  of 108 and 107 call options  (rights to purchase  Common  Stock).
These call options are exercisable for 10,800 and 10,700 shares of Common Stock,
respectively,  at a  strike  price  of $10 per  share.  The  call  options  were
purchased, in ordinary brokerage  transactions,  for an aggregate purchase price
of approximately $26,170. 


                                   Signature

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


                                            April 22, 2005

                                            XMARK ASSET MANAGEMENT, LLC

                                            /s/ Mitchell D. Kaye 
                                            ------------------------------------
                                            Mitchell D. Kaye, Manager


Attention:  Intentional  misstatements  or omissions of fact constitute  Federal
criminal violations (See 18 U.S.C. 1001).