As filed with the Securities and Exchange Commission on August 9, 2001


                                                 Registration No. 333-62770

--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549
                                ----------------

                 PRE-EFFECTIVE AMENDMENT NO. 1 TO FORM S-3

                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933
                                ----------------
                                 CARESIDE, INC.
             (Exact name of registrant as specified in its charter)


                                                            
            Delaware                           3841                 23-2863507
 (State or other jurisdiction of   (Primary Standard Industrial  (I.R.S. Employer
 incorporation or organization)     Classification Code Number) Identification No.)

                  6100 Bristol Parkway, Culver City, CA 90230
                                 (310) 338-6767
              (Address, including zip code, and telephone number,
       including area code, of registrant's principal executive offices)
                                ----------------
                              W. Vickery Stoughton
                     Chairman of the Board of Directors and
                            Chief Executive Officer
                                 Careside, Inc.
                              6100 Bristol Parkway
                             Culver City, CA 90230
                                 (310) 338-6767
           (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)
                                ----------------
                                With copies to:
                             Barry M. Abelson, Esq.
                             Julia D. Corelli, Esq.
                              Pepper Hamilton LLP
                             3000 Two Logan Square
                             Philadelphia, PA 19103
                                 (215) 981-4000
                                ----------------
  Approximate date of commencement of proposed sale to the public: As soon as
practicable after this Registration Statement becomes effective.
  If the only securities being registered on this form are being offered
pursuant to dividend or interest reinvestment plans, please check the following
box. [_]
  If any of the securities being registered on this form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or
interest reinvestment plans, check the following box. [X]
  If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following
box and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. [_]
  If this Form is a post-effective amendment filed pursuant to Rule 462(C)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [_]
  If delivery of the prospectus is expected to be made pursuant to Rule 434,
check the following box. [_]
                                ----------------
                        CALCULATION OF REGISTRATION FEE
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--------------------------------------------------------------------------------



                                              Proposed       Proposed
                                              Maximum        Maximum      Amount of
   Title of Each Class of     Amount to be Offering Price   Aggregate    Registration
Securities to be Registered    Registered    Per Share    Offering Price      Fee
-------------------------------------------------------------------------------------
                                                             
Common Stock, par value
 $.01.......................   14,195,890        (2)              (2)          (2)


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--------------------------------------------------------------------------------

(1)  All of the shares of Common Stock offered hereby are being sold for the
     accounts of selling stockholders named herein. See "Selling Stockholders"
     herein. We initially included 14,482,743 shares of common stock on this
     registration statement when we filed it on June 11, 2001. We are removing
     286,853 shares, leaving a balance of 14,195,890 shares of common stock
     registered herein.


(2)  A registration fee of $8,043.96 was previously paid in connection with the
     initial filing of this registration statement on June 11, 2001 based on a
     proposed maximun offering price per share of $2.415 and a proposed maximum
     aggregate offering price of $34,975,824.35, calculated at that time in
     accordance with Rule 457(c) under the Securities Act.


                                ----------------
  THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT
SHALL FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT OF 1933, AS AMENDED, OR UNTIL THIS REGISTRATION STATEMENT
SHALL BECOME EFFECTIVE ON SUCH DATE AS THE SECURITIES AND EXCHANGE COMMISSION,
ACTING PURSUANT TO SECTION 8(A), MAY DETERMINE.

--------------------------------------------------------------------------------
--------------------------------------------------------------------------------



                     14,195,890 Shares Of Common Stock



                               [LOGO OF CARESIDE]

  The selling stockholders named in this prospectus are offering or may offer
in the future 14,195,890 shares of our common stock which we have issued or
which we may issue when selling stockholders exercise warrants to purchase our
common stock.


  The selling stockholders may sell these shares from time to time in brokers'
transactions, negotiated transactions, or otherwise at prices current at the
time of sales. We will not receive any proceeds from these sales.


  We will pay all expenses of the registration of these shares, except
brokerage commissions and transfer taxes, which will be paid by the selling
stockholders. We estimate that the expenses will be $50,000.


  Our common stock is listed on the American Stock Exchange under the symbol
"CSA." On August 8, 2001, the closing sale price of our common stock as
reported by the American Stock Exchange was $3.90 per share.


  Investing in our common stock involves significant risks. See "Risk Factors"
beginning on page 4.


  Neither the Securities and Exchange Commission nor any state securities
commission has approved or disapproved of these securities or determined if
this prospectus is truthful or complete. Any representation to the contrary is
a criminal offense.

                              August 9, 2001



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--------------------------------------------------------------------------------

                               ----------------
                               TABLE OF CONTENTS



                                        
 .  About Careside ........................   1
 .  Risk Factors...........................   4
 .  Special Note Regarding Forward-Looking
   Statements.............................  14
 .  Use of Proceeds........................  14
 .  Dilution...............................  15
 .  Selling Stockholders...................  16
 .  Plan of Distribution...................  21
 .  Legal Matters..........................  23
 .  Experts................................  24
 .  Where You Can Get More Information.....  25
 .  Incorporation of Certain Documents by
   Reference..............................  25



                               ----------------


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--------------------------------------------------------------------------------



                              ABOUT CARESIDE




  This summary does not contain all of the information that you should consider
before investing in our common stock. You should read the entire prospectus
carefully, including the "Risk Factors" section, the financial statements and
the notes to those financial statements.


                                    Careside



  Careside has developed and sells a proprietary blood testing system called
the Careside system. It is designed to decentralize laboratory operations. The
system consists of two blood testing devices and disposable cartridges and
reagents used in the devices as well as a computer link. The Careside
Analyzer(R) tests each of the three components of blood--whole blood, serum and
plasma. It uses our proprietary disposable test cartridges and performs 41
different tests. The H-2000 performs 18 hematology tests on whole blood. The
Careside Connect facilitates data interchange between the two devices and other
medical information systems.


  The Careside system performs blood tests in the same location as the patient,
or what is commonly called point-of-care testing. Blood testing is a
significant part of routine and critical patient care. Today, almost all blood
testing is done by sending the blood samples to hospital or commercial
laboratories. Because of transportation time and several processing steps,
these central laboratories generally take between 4 and 24 hours to provide
test results to the doctor. We believe that the Careside system is a platform
for solving the limitations of central blood testing laboratories and redefines
the market for point-of-care testing.



  Our goal is to make decentralized testing with the Careside system the
standard for routine and critical care blood testing.



  As of August 2001, the FDA has cleared or exempted the Careside Analyzer for
all 41 blood tests for professional laboratory use and the H-2000 for 18
additional hematology tests. The Careside system's 59 different blood tests
represent most of the routine blood tests ordered by physicians. In addition,
the FDA has cleared the Careside Analyzer as a "point-of-care" device. This
clearance means that properly trained non-technical personnel can operate the
Careside Analyzer, eliminating the need for a lab specialist to oversee each
test. We intend to seek the same designation for the H-2000 in 2001.




  Our commercial product launch occurred in December 1999, at which time the
Careside system offered 53 tests. By the beginning of the second quarter of
2000, we were experiencing issues in both the software and hardware of the
Careside Analyzer that made us question the reliability of the device in the
field. We also experienced technical problems with electrochemistry tests. As a
result, we pulled back from the market and corrected the issues that gave rise
to the reliability concerns. We did not lose any customers or have to
repurchase any devices as a result of these technical difficulties. Rather, we
worked with our customers to ensure the reliability of the test results each
customer received from the Analyzer. We completed the revisions to the
electrochemistry tests and modifications to the Analyzer by November 2000. The
revisions were made and verified in the fourth quarter of 2000. The changes
delayed our ability to market the Analyzer and its disposable cartridges. As a
result, our sales through early 2001 were predominantly H-2000s.


  At present, we sell the components of the Careside system separately in the
United States through our own sales force. We have distribution agreements with
third party distributors to supplement our sales force. We have entered into
several distribution agreements and expect to finalize others in 2001. To date,
our H-2000 sales have been weighted towards foreign markets and veterinary use.
We are focusing our 2001 marketing efforts on the U.S. human market.




  Our concept and technology originated with SmithKline Beecham Clinical
Laboratories, Inc. (SBCL). In 1993, SBCL conducted extensive surveys of the
point-of-care market. As a result, in 1994, SBCL started our predecessor
business to develop the technology we use today. In November 1996, we acquired
the assets and




contracts used in the predecessor business, including intellectual property,
equipment and other assets to continue the development of point-of-care
diagnostic technology and to create a commercial product. Several senior
members of our management team worked on this point-of-care project at SBCL,
including W. Vickery Stoughton, our Chief Executive Officer, and Thomas H.
Grove, Executive Vice President--Chief Technology Officer. Quest Diagnostics
Incorporated later acquired SBCL.


  Our publicly-traded common stock is listed on the American Stock Exchange
under the ticker symbol "CSA," and our publicly-traded warrants under the
symbol "CSA.WS". Our principal executive offices are located at 6100 Bristol
Parkway, Culver City, California 90230. Our telephone number is (310) 338-6767.

                                       2


                                  The Offering



                           
Shares offered by selling
 stockholders:..............  14,195,890 (1)
Use of Proceeds:............  We will not receive any of the proceeds from the sale of
                              shares of common stock by the selling stockholders, but we
                              could receive up to approximately $14.4 million from the
                              exercise of warrants with underlying common stock registered
                              on this registration statement (see "Dilution" on page 14).
                              Any proceeds will be used for working capital purposes (2).


--------
(1) Of these shares, approximately

  .  8,417,655 are shares of common stock held by the selling stockholders,
     of these,


    .  6,475,451 shares of common stock were issued upon conversion of
       outstanding shares of our series C convertible preferred stock on the
       day prior to effectiveness of this registration statement at an
       assumed conversion price of $1.55 per share. The actual conversion
       price will be 80% of the average trading price of our common stock
       over the five trading days prior to effectiveness of the registration
       statement of which this prospectus is a part. The actual conversion
       price will not be less than $1.55 or more than $1.94,


    .  199,253 shares of common stock were issued upon conversion of shares
       of our series B preferred stock and were not previously registered,
       and


    .  1,742,951 shares were issued in a private placement to a single
       investor in December 2000 and January 2001.

  .  41,324 shares of common stock are issuable upon exercise of warrants
     exercisable at $2.75 per share,
  .  45,824 shares of common stock are issuable upon exercise of warrants
     exercisable at $2.25 per share,



  .  5,173,716 shares of common stock are issuable upon exercise of
     outstanding warrants issued in connection with the sale of our Series C
     Convertible Preferred Stock at an exercise price of $2.55 per share, and


  .  517,371 shares of common stock are issuable upon exercise of outstanding
     warrants issued to our placement agent in connection with the sale of
     our Series C Convertible Preferred Stock at an exercise price of $1.94
     per share.


(2) This figure assumes that those warrants are exercised without using their
    cashless exercise feature.


                                       3


                                  RISK FACTORS

  An investment in our common stock involves many risks. These risks may be
substantial and are inherent in the business of Careside. You should carefully
consider the following information about these risks, together with the other
information in this prospectus, before buying common stock.

  If any of the following risks actually occurs, our business and prospects
could be materially adversely affected, the trading price of our common stock
or warrants could decline, and you might lose all or part of your investment.

We Have A Limited Operating History By Which To Evaluate Our Business




  We have no history which would demonstrate an ability to generate revenue.
Since our inception, we have incurred significant losses. Through December 31,
2000 and June 30, 2001 our accumulated losses have totaled $45.2 million and
$52.2 million, respectively. We have generated only a small amount of revenue
from product sales and will continue to incur significant additional operating
losses until we have sold a sufficient number of our products. Because we have
a limited operating history, we have not demonstrated an ability to:




  .  respond to competitive developments;


  .  develop new relationships and maintain existing relationships with
     suppliers, distributors and potential customers;


  .  attract, retain and motivate qualified employees; and


  .  produce, distribute and market our product.


We May Never Be Profitable

  Even if we are able to generate revenue from sales of our products, we may
never be profitable. There are several reasons why this might happen:

  .  We may not be able to reduce our manufacturing costs to levels necessary
     for profitability.
  .  We may have to lower our prices to remain competitive.
  .  We may experience delays in developing additional tests or product
     upgrades.
  .  We may experience problems in production, distribution or marketing.

  Even if we are able to generate revenue from sales of our products, we may
never be profitable. There are several reasons why this might happen:


  .  We may not be able to reduce our manufacturing costs to levels necessary
     for profitability.


  .  We may have to lower our prices to remain competitive.


  .  We may experience delays in developing additional tests or product
     upgrades.


  .  We may experience problems in production, distribution or marketing.


  Even if we do achieve profitability, we may not sustain or increase
profitability on a quarterly or annual basis in the future.


                                       4



Given Our Limited Operating History And Recurring Losses, We May Be Unable To
Continue As A Going Concern


  Since our inception, we have generated minimal revenues, incurred significant
losses from operations and accumulated some debt. We anticipate that we will
incur additional losses over at least the next year. Our consolidated financial
statements for each of the three years in the period ended December 31, 2000
have been prepared assuming that we will continue as a going concern. As
indicated in our consolidated financial statements for the year ended December
31, 2000, we incurred a net loss in 2000 of $16,703,485 and used cash for
operating activities of $15,661,957. Our accumulated deficit was $45,199,361.
Careside's independent accountants have stated in their audit opinion that
these factors raise substantial doubt about Careside's ability to continue as a
going concern. Further, additional financing will be needed by Careside to fund
its operations. In the event our operations are not profitable or do not
generate sufficient cash to fund our business, there will be substantial doubt
about our ability to continue as a going concern.


Unavailability Of Additional Funding May Adversely Affect Our Business


  At June 30, 2001, our principal source of liquidity was approximately $5.6
million in cash and cash equivalents. Our current liquidity and sales revenue
expected in 2001 are projected to be sufficient to fund our operating expenses
and capital requirements for at least eight months. Our future liquidity and
capital funding requirements will depend on numerous factors, including:


  .  the extent to which our products gain market acceptance;


  .  the exercise of outstanding warrants to purchase common stock;


  .  the timing of regulatory actions regarding our products; and


  .  the costs and timing of expansions of sales, marketing and manufacturing
     activities.


Additional capital may not be available on terms acceptable to us, if it is
available at all. If adequate funds are not available, our business, results of
operations and financial condition could be materially and adversely affected.
We may be required to delay, reduce or eliminate product development programs.
We may also have to reduce our planned marketing and sales activities, or
license to third parties rights to commercialize our products or technologies.
These reductions could, in turn, affect our relationships with our clients and
threaten our ability to continue as a going concern.


The Medical Community May Not Accept the Careside System

  The Careside Analyzer and our patented test cartridges, the H-2000 and the
Careside Connect are our only products. We will not be able to operate
profitably unless these products achieve a significant level of market
acceptance. The following factors are the greatest risks to our market
acceptance:

 We May Fail to Develop the Comprehensive Test Menu Needed to Sell Our Product

  If we are not able to fully develop further tests to complete our proposed
comprehensive test menu, customers may not buy our products. One of our major
selling points to potential customers will be the breadth of our menu.


 We May Be Unable to Change How Tests Are Ordered


  We may not be able to demonstrate the economic or clinical benefits of the
Careside system sufficiently to convince members of the medical community to
change the way they order tests. Currently, physicians and hospitals typically
order blood tests from central laboratories.

                                       5


 Managed Care Contracts May Limit Our Market Penetration

  Our ability to sell to healthcare providers may be limited by managed care
relationships. Many health maintenance and managed care organizations have
exclusive contracts with laboratories that require participating or employed
physicians to send patient specimens only to contracted laboratories.
Consequently, these physicians may be precluded from using Careside's products
unless they obtain a waiver from the relevant health maintenance or managed
care organization.


 We May Be Unable To Keep Pace With Changing Technology


  Blood testing technology is evolving. Other companies may develop products in
response to technological changes that make our products noncompetitive.

 CLIA May Discourage Healthcare Providers From Using Point-of-Care Testing


  Careside system users will have to be licensed under the Clinical Laboratory
Improvement Amendments of 1988. While the Careside system is designed to make
licensure easy, CLIA licensing requirements may make healthcare providers
reluctant to initiate, continue or expand patient testing using the Careside
system.


We May Not Be Able To Further Develop Our Products


  In order for us to expand our test menu, we must complete the development of
one of the four types of disposable cartridges. The immunochemistry cartridge
has been designed but has not undergone testing. Factors outside our control
may delay our proposed development schedule for this cartridge. These factors
include:


  .  delays in regulatory clearance,
  .  technological difficulties,
  .  restrictions on access to proprietary technology of strategic partners,
     and
  .  changes in the healthcare, regulatory or reimbursement environment.

Reductions In Third-Party Reimbursement For Tests May Hurt Our Business


  Current reimbursement amounts for diagnostic tests from government
authorities, private health insurers and other third-party payers, such as
health maintenance organizations, to test providees may not be maintained. Any
decrease in test reimbursement amounts may reduce the demand for diagnostic
tests. This may, in turn, decrease the demand for our products or force us to
lower our sales prices. In addition, legislative proposals to reform healthcare
and the trend toward managed healthcare in the United States may require lower
prices for our products.


Our Limited Sales, Marketing and Distribution Experience May Hurt Our Sales


  We may not be able to recruit or retain direct sales and marketing personnel
who will successfully implement our marketing strategy. We intend to distribute
our products in the United States through our own sales force and domestic
distributors, and internationally through distributors. Establishing a sales
and marketing capability will require substantial efforts and significant
resources.


Ineffectiveness Of Third-Party Distributors May Hurt Our Sales


  We will depend on third party distributors to assist us in promoting market
acceptance and creating demand for our products. We have granted Fuji Photo
Film Co. Ltd. a right of first refusal to distribute the

                                       6



Careside system exclusively in Japan and non-exclusively in some of the other
Asian countries. Our existing arrangements to distribute our products worldwide
may not be sufficient. We may not be able to maintain these arrangements or
enter into additional distribution arrangements. In addition, we have little
control over the resources that distributors will devote to the marketing of
our products.


Our Contract Manufacturers May Not Adequately Meet Our Future Product Demand

  We will depend upon outside vendors to manufacture most of the Careside
system, including the Careside Analyzer and components of the disposable
testing cartridges. We will have only limited control over third-party
manufacturers as to quality control and timing of production and delivery. We
cannot be certain that outside manufacturers will be able to provide us with a
sufficient number of instruments and cartridge components on a timely basis.

  At present, we depend on UMM Electronics, Inc. for the manufacture and supply
of Analyzers, International Technodyne, Inc. for our supply of chemical
reagents, and Fuji Photo Film Co., Ltd. for dry film used in our cartridges.
Alternate third party suppliers are available for each of these items, but a
switch in manufacturers or suppliers could delay the manufacture of and
interrupt the supply of our product. This could reduce our revenues.


Our Inability To Forecast Our Dry Film Requirements Could Result In Excess Film
Inventory


  Our contract with Fuji requires us to forecast our requirements for dry film
on a periodic basis. If we do not accurately forecast our needs, we may end up
with too much or too little supply of dry film. Excess film inventory could
result in obsolescence since dry film has a limited shelf life. Too little
inventory could hurt our ability to meet our customers' orders.


Our Lack Of Manufacturing Experience Could Prevent Us From Meeting Cartridge
Demand


  We will be assembling the cartridges at Careside. We have limited experience
operating a manufacturing/assembly business. We will need to assemble
significant and increasing quantities of test cartridges on a timely basis,
while maintaining strict quality standards. We have converted from manual
production of cartridge components and assembly to an automated system to
produce cartridge components. We may not be able to achieve and maintain
product accuracy and reliability when producing the cartridges in the
quantities required, on a timely basis or at an acceptable cost.






Loss Of Our CEO Or Other Key Personnel Would Hinder The Success Of Our Business

  The loss of key employees or unsuccessful recruiting efforts will harm us.
Competition for qualified and talented individuals with experience in point-of-
care testing is intense. Our success depends on our ability to retain the
services of Mr. Stoughton, our Chairman of the Board of Directors and Chief
Executive Officer. Mr. Stoughton has over 20 years experience as a senior
executive of several large hospitals and over four years experience as
President of SmithKline Beecham Clinical Laboratories, Inc. We also need to
attract additional sales and marketing, research and development, and
experienced manufacturing personnel.

Failure To Manage The Expansion Of Our Operations May Hurt Our Business


  We will need to expand our operations if we are successful in achieving
market acceptance for the Careside system. This expansion will result in
additional responsibilities for management and place significant demand upon
our management, our operating and financial systems and our resources. To
accommodate this growth and to compete effectively, we will need to implement
and improve our internal operating systems and controls, and to hire and train
additional personnel. Failure to do so may impede our success.


                                       7


Our Competitors Have Advantages Over Us

  Our business may fail because our market is highly competitive. Our primary
competitors are large diagnostic device manufacturers, commercial and hospital
laboratories and other point-of-care device manufacturers. The large device
manufacturers and commercial and hospital laboratories have significant
marketing, manufacturing, financial and managerial resources, and have
substantially greater research and development capabilities than we do. We
expect that manufacturers of conventional blood testing products used in
centralized laboratories will compete intensely with us to maintain their
market share. Commercial and hospital laboratories may try to influence
providers against the Careside system to protect their revenue. Other point-of-
care companies have already sold their product in the marketplace. We
anticipate competition from these manufacturers in discrete testing areas such
as critical care testing. Many of these companies offer tests that will cost
less than the Careside system and so may be attractive to some of our
customers.


Failure To Protect Our Proprietary Technology Is A Crucial Part of Our Business

  The success of our business will depend on our ability to protect our
proprietary technology. Our business may fail if we are not able to do so.

  We currently have three U.S. patents granted on our cartridge technology. Six
other patents have been filed to date and we expect to file additional patents
in the future. International patents have also been filed. The six patents
filed to date include one that was filed jointly with International Technidyne
Inc. and covers a reagent that was co-discovered. The other five include one
more cartridge patent and four device patents. We cannot be certain that these
additional patents will be granted or that our patents will withstand any
challenges by third parties. Factors impacting our proprietary technology,
which may ultimately impact our success, include:


 Our Technology May Infringe on the Proprietary Rights of Third Parties

  Universities and government laboratories, physicians and other corporations
are conducting substantial research in point-of-care diagnostic blood testing
technology. Given the nature of our industry, it is possible that patent
applications have been filed by others, and patents may be issued to them,
relating to specific diagnostic products and processes. Patent applications in
the U.S. are secret until the patent is issued. We cannot know whether
competing applications have been filed. A prior conflicting patent application
would detract from the value of our patents. In addition, if we use
technologies, products or processes covered by patent applications filed by
others, or by patents issued to others, we may have to obtain licenses. We may
not be able to obtain such licenses on reasonable terms, or at all.

 We May Be Unable to Build Brand Loyalty Because Our Trademarks and Trade Names
 May Not Be Protected

  Our registered or unregistered trademarks or trade names may be challenged,
canceled, infringed, circumvented or declared generic or determined to be
infringing on other marks. We may not be able to protect our rights to these
trademarks and trade names, which we need to build brand loyalty. Brand
recognition is critical to our short term and long term marketing strategies.

 Our Trade Secrets May Be Disclosed

  We also rely on unpatented trade secrets to protect our proprietary
technology. We attempt to protect our proprietary technology through an
employee handbook and agreements with our executive officers. Our employees
have not signed confidentiality agreements. The confidentiality provisions in
the handbook and executives' agreements may not be enforceable under applicable
law. Other companies may independently develop or otherwise acquire equivalent
technology or gain access to our proprietary technology.

                                       8


 Our Proprietary Rights May Fail to Protect Our Business

  We may have to resort to litigation to protect or defend our rights. This
could result in substantial costs and the diversion of management's attention.
If we lost any such litigation, we could lose our competitive position, be
required to obtain licenses from third parties or be prevented from
manufacturing, selling or using certain of our products.

 We Do Not Own All Necessary Intellectual Property



  The film in all of our test cartridges and the electrochemistry slide in our
electrochemistry test cartridge is manufactured by and is based on patents
owned by Fuji Photo Film Co., Ltd. If our access to these Fuji products
terminated, we would have to use other products that would be based on
alternative technology. We believe that other products based on alternative
technology do exist, but we cannot be sure that we would be able to achieve
access to any such technology. Our development efforts could be delayed until
we achieved access to the alternative technology. If we have to use products
based on alternative technology, we may have to modify our product to
accommodate this new technology. This would cause substantial delay and cost.
If alternative technology is unavailable, we would have to change our testing
methodologies. This would also cause substantial delay and cost. We presently
have no indication that our access to the Fuji products is threatened and we
believe that there is only a small risk that we would be denied access to
alternative technologies.




Extensive Government Regulation May Increase Our Expenses and Cause Delays In
Our Product Commercialization


  Our products are medical devices subject to extensive regulation by the FDA,
similar agencies in other countries, and to a lesser extent, by state
regulatory authorities. The following are the greatest regulatory risks we
face:

 We May Incur Substantial Expenses to Comply With Good Manufacturing Practices
 (GMP) and Other Manufacturing Regulations

  Our manufacturing facilities and processes will be required to comply with
strict federal regulations, including Good Manufacturing Practices, or GMP, and
quality system requirements, regarding validation and quality of manufacturing.
We have limited experience in complying with regulations governing our products
and manufacturing facilities. We must devote substantial resources and
management attention to monitoring and maintaining compliance with governmental
regulations. If we, or our manufacturing partners, violate applicable
regulations, we may be sanctioned and our production or distribution may be
suspended. In addition, the FDA may withdraw the approval or clearance to
market of any of our products.

 We May Need to Apply For Additional FDA Pre-Market Clearances if We
 Significantly Modify Our Products or Add to Our Test Menu, Which May Result In
 Rejections Or Delays




  We are continuously subject to FDA regulations regarding laboratory and
clinical testing. When we seek to improve our product and add additional tests
to our test menu, we may be required to submit new applications for pre-market
clearance. We cannot be certain that we will be able to obtain all necessary
approvals for product improvements or additional tests on a timely basis, or at
all. Such delays or rejections could adversely affect our business.


                                       9



The Issuance Of The Significant Number Of Shares That Are Eligible For Future
Sale Could Lower Our Market Price


  As of the effective date of this registration statement we have 18,169,790
shares of common stock outstanding. The following table shows the eligibility
of these shares for public sale:





 # of
 Shares                                    Status
 ------                                    ------
         
 11,143,246 registered and freely tradable without restrictions or further
            registration under the Securities Act
 5,084,340  may be sold into the public market under Rule 144 currently,
            without registration under the Securities Act
 1,742,951  issued in a private placement to a single investor in December 2000
            and January 2001, and not yet Rule 144 eligible
 199,253    issued upon conversion of our series B convertible preferred stock
            and not yet registered and not yet Rule 144 eligible



14,195,890 shares are being registered in this registration statement. The
following table shows the status of these shares:





   # of
  Shares                                  Status
  ------                                  ------
        
 1,742,951 issued in a private placement to a single investor in December 2000
           and January 2001, and not yet Rule 144 eligible
 87,148    issuable upon exercise of warrants issued to the investor in our
           December 2000 and January 2001 private placement
 6,475,451 issued upon the automatic conversion of series C preferred stock on
           the day prior to effectiveness of this registration statement
 5,691,087 issuable upon exercise of warrants issued in connection with the
           private placement of our series C convertible preferred stock
 199,253   issued upon conversion of series B preferred stock and not
           previously registered



  The following table shows the shares of common stock that we may issue in the
future:





 # of
 Shares                                 Status
 ------                                 ------
         
 996,916    issuable upon exercise of outstanding options
 2,000,000  issuable upon exercise of our publicly traded warrants
 11,487,357 issuable upon exercise of outstanding warrants that are not
            publicly traded
 464,863    issuable upon exercise of options that we may grant under our
            current stock option plans and employee stock purchase plan



  The public resale of


  .  our outstanding privately held common shares,


  .  common shares issuable upon exercise of our outstanding warrants and
     options,


  .  common shares issued upon conversion of our Series C Convertible
     Preferred Stock, or


  .  common shares issuable upon exercise of options that we may grant in the
     future under our current stock option plans and employee stock purchase
     plan


could have a depressive effect on the market price of our common stock.



                                       10



A Large Percentage Increase In Our Publicly Traded Common Stock May Lower The
Market Price Of Our Common Stock


  We have registered the resale of 8,417,665 of our total outstanding shares of
common stock, which represents an increase of 46.3% in the number of our
publicly tradable shares. Also, we have outstanding options and warrants that
are exercisable into approximately a total of 14,484,273 shares of common
stock, some of which are registered in this registration statement and some of
which have been previously registered. The issuance of these shares would
result in a 79.7% increase in our outstanding common stock. The large
percentage increases in our outstanding and registered common stock could have
a depressive effect on the market price of our common stock.


Holders Of Our Common Stock May Be Materially Diluted By The Exercise Of
Outstanding Warrants Issued In Connection With Our Series B And Series C
Preferred Stock


  3,993,970 additional shares of our common stock may be issued upon the
exercise of the callable common warrant issued to the purchaser of our series B
preferred stock. The exercise price of this warrant can be 95% of a two day
average market price of our common stock. Issuance of these warrant shares at
such price may have a depressive effect on the market price of our common
stock.


  5,691,087 shares of our common stock may be issued upon the exercise of
warrants issued in connection with the sale of our series C preferred stock.
The exercise price of these warrants is $2.55 for 5,173,716 of these shares and
$1.94 for the remaining 517,371 shares. If these shares are issued at an
exercise price that is less than the market price of our common stock at that
time, the holders of our common stock may be materially diluted.


The Conversion Of Our Series C Preferred Caused Dilution To Our Stockholders


  Our series C preferred stock automatically converted on the day prior to the
effective date of this registration statement. The conversion price was 80% of
the five day average trading price prior to conversion, or $ . The 20% discount
from market may have a depressive effect on the market price of our common.


Control Of Careside By Our Management And Principal Stockholders Could Conflict
With Other Stockholders' Interests


  The interests of our directors and executive officers, and our principal
stockholders could conflict with the interests of other Careside stockholders.
As of the date of this prospectus, our directors and executive officers,
together with the principal stockholders of Careside, beneficially own or
control approximately 46.7% of our common stock. This percentage takes into
account the effect of options and warrants. Accordingly, these stockholders may
be able to influence the outcome of stockholder votes, including votes
concerning the election of directors, certain amendments to our charter and
bylaws, and the approval of significant corporate transactions such as a merger
or a sale of our assets. This influence could have the effect of delaying,
deferring or preventing a change in control of Careside.


Future Issuances Of Preferred Stock May Dilute Rights Of Common Stockholders

  Our Board of Directors has the authority to issue up to 4,836,117 additional
shares of preferred stock and to determine the price, privileges and other
terms of such shares. The Board may exercise this authority without the
approval of the stockholders. The rights of the holders of common stock may be
adversely affected by the rights of the holders of any preferred stock that may
be issued in the future. In addition, the issuance of preferred stock may make
it more difficult for a third party to acquire control of Careside.


                                       11



Statute, Charter And By-laws May Delay Or Prevent Someone From Acquiring Us


  We will be subject to the anti-takeover provisions of Section 203 of the
Delaware General Corporation Law. Section 203 could delay or prevent a third
party or a significant stockholder from acquiring control of us. In general,
Section 203 prohibits a publicly held Delaware corporation from engaging in a
business combination with an interested stockholder for a period of three years
following the date the person became an interested stockholder, unless the
business combination or the transaction in which the person became an
interested stockholder is approved in a prescribed manner. Generally, a
business combination includes a merger, asset or stock sale, or other
transaction resulting in a financial benefit to the interested stockholder. An
interested stockholder is a person who, together with affiliates and
associates, owns 15% or more of a corporation's voting stock. Section 203 may
prohibit or delay mergers or other takeover or change in control attempts with
respect to us. As a result, Section 203 may discourage attempts to acquire us
even though such transaction may offer our stockholders the opportunity to sell
their stock at a price above the prevailing market price.


  In addition, our charter and by-laws may have the effect of discouraging,
delaying or preventing a merger, tender offer or proxy contest involving us.
Any of these anti-takeover provisions could lower the market price of our
common stock.


The Market Prices Of Shares Of Common Stock And Warrants May Be Volatile


  The market prices of shares of common stock and warrants may be highly
volatile. This means our stock prices may fluctuate significantly depending on
many factors, including:


  .   the success of our new products or new products introduced by our
      competitors,
  .   developments with respect to our patents and other proprietary rights,

  .   our ability to meet sales and earnings expectations of securities
      analysts


  .   our need to raise financing through sale of our equity, and

  .   changes in general market conditions.

Our Total Assets Include Significant Intangible Assets And The Write-Off Of A
Significant Portion Of Unamortized Intangible Assets Would Negatively Affect
Our Results Of Operations


  Our total assets reflect significant intangible assets. As of June 30, 2001,
we had approximately $1.9 million of net intangible assets representing 12.6%
of our total assets and 21.2% of our stockholders' equity. Intangible assets
consist of goodwill associated with our acquisition of Texas Instrument
Laboratories, Inc., representing the excess of the purchase price and related
costs over the value assigned to the tangible assets we acquired in that
acquisition. Periodically, we assess whether there has been an impairment in
the value of our goodwill. Beginning January 1, 2002, we will account for our
intangible assets under Statement of Financial Accounting Standards No. 142,
Goodwill and Other Intangible Assets. Under this standard, we will no longer
amortize our goodwill, but we will continue to periodically assess it for
impairment by comparing the carrying value to the estimated fair value. If the
estimated fair value is less than the carrying value, the goodwill will be
considered impaired and the impairment losses will be reported as an operating
expense in current results of operations. Any determination requiring the
write-off of a significant portion of unamortized intangible assets would
negatively affect our results of operations and total capitalization. As of
June 30 2001, we have determined that no impairment existed.



                                       12





The Terms Of Some Of Our Securities May Encourage Short-Selling Of Our Common
Stock Which Could Depress The Market Price Of Our Common Stock


  Until the warrants issued in connection with our series B convertible
preferred stock are exercised, there may be increased risk of short-selling of
our common stock, which could have a depressive effect on the market price of
our common stock. The holder of this warrant can exercise on its own initiative
at $14 per share. Or, we can call this warrant in which case the exercise price
is 95% of the two day average trading price prior to the call. If we call the
warrant, then, by short-selling our common stock, the warrant holder could
depress the market price of our common stock, enabling the holder to acquire
more shares upon any subsequent call of these warrants. This would increase the
dilution of the other stockholders' equity in Careside attributable to the
discount off market prices inherent in the exercise price.


  A short-sale is the sale of a security that the seller does not own or that
the seller owns but does not deliver. In order to deliver the security to the
purchaser, the short-seller will borrow the security, typically from a broker-
dealer or an institutional investor. The short-seller later closes out the
position by returning the security to the lender, typically by purchasing
equivalent securities on the open market. In general, short-selling is utilized
to profit from an expected downward price movement, or to hedge the risk of a
long position in the same security or in a related security. Although short-
selling serves useful market purposes, it also may be used as a tool for
manipulation. Further, short-selling can increase stock price volatility.


  Our series C convertible preferred stock converted automatically upon
effectiveness of this registration statement at a price that depended upon the
market price of our common stock. The lower the market price for our common
stock, the greater the number of shares of common stock the selling
stockholders could have acquired upon conversion of our series C convertible
preferred stock. Selling stockholders could have used a short-selling strategy
to drive down the market price of our common stock prior to the conversion.
This would increase the number of shares issued upon the conversion. Such a
short-selling strategy, if used, could have a depressive effect on the market
price of our common stock.


                                       13


               SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

  Some of the statements contained in this prospectus discuss future events and
developments, including our ability to generate revenue, income and cash flows,
or state other "forward-looking" information. We generally identify these
forward-looking statements by using the words "anticipate," "believe,"
"estimate," "expect," and similar expressions. These statements include, but
are not limited to, information about our cash available to fund our future
operations, future enhancements to our products, growth of the in vitro testing
and point-of-care testing markets, completion of the immunochemistry tests
cartridge, and the planned addition of further tests to our menu. Those
statements are subject to known and unknown risks, uncertainties and other
factors that could cause the actual results to differ materially from those
contemplated by the statements. Important factors that may cause actual results
to differ include those set forth under "Risk Factors" beginning on page 5.

  We do not promise to update forward-looking information to reflect actual
results or changes in assumptions or other factors that could affect those
statements.

                                USE OF PROCEEDS

  We will not receive any of the proceeds from the sale of the shares by the
selling stockholders pursuant to this prospectus. However, we may receive up to
approximately $14.4 million from the exercise of warrants with underlying
common stock registered hereunder. This figure assumes that those warrants are
exercised without using their cashless exercise feature. There is no guarantee
that any warrants will be exercised or that we will receive any proceeds. The
proceeds, if any, would be used for working capital purposes.


                                       14


                                    DILUTION

  The selling security holders listed in this prospectus may offer and sell
shares of our common stock for their own account. We will not receive any
proceeds from any such sales.


  Our net tangible book value as of June 30, 2001 was approximately $7,217,889,
or $0.63 per share of common stock. As the shares of common stock being
registered in this prospectus had already been issued in a private transaction,
there is no additional dilution to the net tangible book value per share of
common stock as a result of sales of shares registered in this registration
statement.


                                       15



                         SELLING SECURITY HOLDERS


  The following table sets forth certain information regarding the beneficial
ownership of the common stock as of August 8, 2001 by each of the selling
security holders. Unless otherwise indicated below, to our knowledge, all
persons listed below have sole voting and investment power with respect to the
shares of common stock, except to the extent authority is shared by spouses
under applicable law.


  The information included below is based upon information provided by the
selling security holders and by our transfer agent. Because the selling
security holders may offer all, some or none of their common stock, no
definitive estimate as to the number of shares thereof that will be held by the
selling security holders after such offering can be provided. In the following
table, column (A) shows all shares beneficially held by the holder at August 8,
2001, and column (B) has been prepared on the assumption that all shares of
common stock registered under this prospectus will be sold.





                                                                                      (B)
                                                                              Common Stock To Be
                                          (A)                                 Beneficially Owned
                                     Common Stock                                If All Shares
                               Beneficially Owned Prior                           Registered
                                   to August 8, 2001                          Hereunder Are Sold
                            ----------------------------------                ----------------------
                                           Shares               Shares That
                                         Underlying            May be Offered
           Name             Shares(1)     Warrants  Percent(2)   Hereunder    Shares     Percent(2)
           ----             ---------    ---------- ---------- -------------- ---------- -----------
                                                                       
Aaron A. Lindberg(3)......                  5,000        *          5,000
Alexander Knopick.........         0        5,291        *          5,291              0          *
Andrew J. Redleaf.........    64,516       51,546        *        116,062              0          *
Anthony Felling(3)........         0       19,407        *         19,407              0          *
Asphalt Green, Inc.(25)...    33,003(11)   21,000        *         47,283          6,720          *
Barrie Ramsay Zesiger.....    65,083       52,000        *        117,083              0          *
Bear Stearns as Custodian
 for Bruce Hendry, IRA....   322,580      257,732      3.1%       580,312              0          *
Bear Stearns as Custodian
 for
 Demetre M. Nicoloff, IRA..   16,129       12,887        *         29,016              0          *
Bear Stearns as custodian
 for Jerry A. Kuny, IRA...    16,129       12,877        *         29,016              0          *
Bear Stearns as Custodian
 for Michael D. Lensing...    16,129       12,887        *         29,016              0          *
Bear Stearns as Custodian
 for Steven D. McWhirter,
 IRA(6)...................    16,129       12,887        *         29,016              0          *
Bradley D. Williams(3)....         0          500        *            500
Callista F. Milroy as TTEE
 under the Trust Agreement
 dated 10/15/99 for
 Callista Milroy..........    18,129(18)   12,887        *         29,016          2,000          *
Castle Creek Health Care
 Partners LLC(26).........   483,870      386,598      4.7%       870,468              0          *
CCL Fund, LLC(27).........   161,290      128,866      1.6%       290,156              0          *
City of Stamford Firemen's
 Pension Fund(25).........    95,654(12)   46,000        *        103,574         38,080          *
Craig L. Campbell.........    19,354       15,464        *         34,818              0          *
Crestview Capital Fund,
 LP(28)...................   322,603      257,750      3.1%       580,353              0          *
Daniel S. and Patrice M.
 Perkins JT WROS..........    50,064       40,000        *         90,064              0          *
David M. Westrum..........    32,258       25,773        *         58,031              0          *
Dean Witter
 Foundation(25)...........    90,843(13)   52,000                 117,083
Dennis A. Gonyea..........    19,354       15,464        *         34,818              0          *



                                       16





                                                                                    (B)
                                                                            Common Stock To Be
                                        (A)                                 Beneficially Owned
                                   Common Stock                                If All Shares
                             Beneficially Owned Prior                           Registered
                                 to August 8, 2001                          Hereunder Are Sold
                          ----------------------------------                ----------------------
                                         Shares               Shares That
                                       Underlying            May be Offered
          Name            Shares(1)     Warrants  Percent(2)   Hereunder    Shares     Percent(2)
          ----            ---------    ---------- ---------- -------------- ---------- -----------
                                                                     
Dolphin Offshore
 Partners L.P.(29)......   321,919(10)  206,186      2.9%       464,250         63,855          *
Donald R. Brattain......    64,516       51,546        *        116,062              0          *
Dorothy J. Hoel.........    19,354       15,464        *         34,818              0          *
Dougherty & Company
 LLC(30)................   274,193      219,072      2.7%       493,265              0          *
DRL Partners(31)........    16,129       12,887        *         29,016              0          *
Edward N. Marshman,
 trustee u/a dtd 9/15/88
 FBO Edward N.
 Marshman...............    52,258       25,773        *         58,031              0          *
Eugene V. Kelly.........     6,945(19)   51,546        *        116,062         22,429
G. James Spinner(3).....    21,129(23)   14,305        *         30,434          5,000          *
Gary A. Bergren.........    19,354       15,464        *         34,818              0          *
Gary Kohler.............    64,516       51,546        *        116,062              0          *
Gerald Kraut(6).........         0       78,441        *         78,441              0          *
Glen Harstad............    16,129       12,887        *         29,016              0          *
Hans Snyder(3)..........     2,000(21)      902        *            902          2,000          *
Helen Hunt..............    42,554       34,000        *         76,554              0          *
Homer H. Marshman, Jr...    16,129       12,887        *         29,016              0          *
Irvin R. Kessler........   483,870      386,598      4.7%       870,468              0          *
James E. Lineberger.....   218,305(20)  103,093      1.7%       232,125         89,273          *
James Laube and Judith
 Laube..................    16,129       12,887        *         29,016              0          *
James Potter(3).........         0          838        *            838              0          *
Jeffrey J. Frommelt.....    24,193       19,330        *         43,523              0          *
Jessica S. Horick(4)....         0        7,895                   7,895
John T. Potter..........    16,129       12,887        *         29,016              0          *
Jonathan P. Horick(3)...         0       93,000        *         93,000              0          *
Kessler Family Ltd.
 Partnership(32)........   161,290      128,866      1.6%       290,156              0          *
L & Co., LLC(33)........    64,516       51,546        *        116,062              0          *
Lawrence B. Shapiro.....    32,258       25,773        *         58,031              0          *
Leonard Anderson........    16,129       12,887        *         29,016              0          *
Lori Stovern............    32,258       25,773        *         58,031              0          *
Louise H. Abrahams......    16,129       12,887        *         29,016              0          *
Maria C. Lloyd..........    80,645       64,433        *        145,078              0          *
Mark Kozberg(3).........         0        9,278        *          9,278              0          *
Mark Peterson(3)........     2,500(22)      902        *            902          2,500          *
Mary C. Anderson........    38,800       31,000        *         69,800              0          *
Meehan Foundation(25)...    28,781       23,000        *         51,781              0          *
Michael E.
 Dougherty(3)...........         0       78,441        *         78,441              0          *
Michael Pint............    32,258       25,773        *         58,031              0          *
Michael T. Dolan(3).....         0        1,804        *          1,804
OTATO Limited
 Partnership(34)........   129,032      103,093      1.3%       232,125              0          *
Paine Webber Custodian
 FBO Demetre M.
 Nicoloff, IRA..........    16,129       12,887        *         29,016              0          *
Paul A. Benenson........    16,129       12,887        *         29,016              0          *



                                       17





                                                                                       (B)
                                                                                Common Stock To Be
                                        (A)                                     Beneficially Owned
                                   Common Stock                                   If All Shares
                             Beneficially Owned Prior                               Registered
                                 to August 8, 2001                              Hereunder Are Sold
                          -------------------------------------                --------------------
                                         Shares                  Shares That
                                       Underlying               May be Offered
          Name            Shares(1)     Warrants     Percent(2)   Hereunder     Shares   Percent(2)
          ----            ---------    ----------    ---------- -------------- --------- ----------
                                                                       
Peter Hajas.............   451,612       360,825         4.4%      812,437             0       *
Pine Inc.(8)(35)........   196,472        96,468(9)      1.6%      283,620         9,320       *
Public Employee
 Retirement System of
 Idaho(5)(25)...........   675,824(16)   412,000         5.8%      927,664       160,160       *
Raymond R. Johnson......    19,354        15,464           *        34,818             0       *
Richard D. Lentz........    16,129        12,887           *        29,016             0       *
Richard L. Abrahams
 Trustee & Louise L.
 Abrahams Trustee for
 the Richard and Louise
 Abrahams Charitable
 Trust..................    16,129        12,887           *        29,016             0       *
RLA 1993 Trust(31)......    41,936        33,506           *        75,442             0       *
Robert Bigley...........    16,129        12,887           *        29,016             0       *
Robert G. Allison.......    48,387        38,660           *        87,047             0       *
Robert H. Paymar(3).....         0           887           *           887
Robert Thomssen.........    62,580        50,000           *       112,580             0       *
Robert W. Elsholtz......    16,129        12,887           *        29,016             0       *
Roger H. Frommelt.......     8,064         6,443           *        14,507             0       *
Roycap, Inc.(36)........   788,616(24) 4,018,970        21.7%      199,253     4,608,333    25.3%
Russell S. King(3)......         0         7,000           *         7,000             0       *
Sasha L. Digges, Mary
 Catherine Knott
 Digges.................    64,516        51,546           *       116,062             0       *
Scott E and Mary T.
 Strickland, JTWROS.....    16,129        12,887           *        29,016             0       *
Shawn P. Weinand........    19,354        15,464           *        34,818             0       *
Stephen C. Heidecker....    16,129        12,887           *        29,016             0       *
Steve Pint..............    32,258        25,773           *        58,031             0       *
Steven Cheney...........    48,387        38,660           *        87,047             0       *
Steven D. McWhirter(6)..    16,129       107,624           *       123,753             0       *
Stuart H. Mason(3)......    16,129        37,887           *        54,016             0       *
Susan Noel Potter(4)....         0           837                       837
The Peregrine Equity
 Fund, LLP(37)..........    32,258        25,773           *        58,031             0       *
Theeuwes Family Trust,
 Felix Theeuwes
 Trustee................    32,541        26,000           *        58,541             0       *
Thomas J. Abood(3)......         0        78,440           *        78,440             0       *
Timothy Mitchell(3).....         0         7,353           *         7,353             0       *
UBS Piper Jaffray as
 Custodian FBO Bradley
 A. Erickson, IRA.......    19,354        15,464           *        34,818             0       *
UBS Piper Jaffray as
 Custodian FBO David H.
 Potter, IRA............    31,290        25,000           *        56,290             0       *
UBS Piper Jaffray as
 Custodian FBO Richard
 C. Perkins, IRA........    41,935        33,505           *        75,440             0       *
UBS--Piper Jaffray as
 Custodian FBO James G.
 Peters, IRA............    25,032        20,000           *        45,032             0       *



                                       18





                                                                                   (B)
                                                                            Common Stock To Be
                                       (A)                                  Beneficially Owned
                                  Common Stock                                If All Shares
                            Beneficially Owned Prior                            Registered
                                to August 8, 2001                           Hereunder Are Sold
                         -----------------------------------                ------------------
                                         Shares               Shares That
                                       Underlying            May be Offered
          Name           Shares(1)      Warrants  Percent(2)   Hereunder    Shares  Percent(2)
          ----           ---------     ---------- ---------- -------------- ------- ----------
                                                                  
Venturetec, Inc.
 BVI(7)(35)............. 1,920,000(14)   33,654      10.7%     1,546,479    407,175    2.2%
William D. Sexton.......    64,516       51,546         *        116,062          0      *
William H. Knott........    36,774       29,381         *         66,155          0      *
William T. Frantz.......   225,145(17)  128,866       1.9%       290,156     63,855      *
Wilmington Trust
 Company, Trustee u/a
 dtd 1/21/27 with Philip
 F. duPont for Jane
 duPont Lunger(5).......   516,129      412,371       5.0%       928,500          0      *
Wolfson Investment
 Partners LP(25)........    66,403(15)   52,000         *        117,083      1,320      *


--------

 *  Represents less than 1% of our outstanding shares of common stock.


 (1)  All shares owned by the selling security holder reflect shares underlying
      series C preferred stock (assuming the floor conversion rate of $1.55 per
      share) except where indicated separately by footnote.


 (2)  The percentage of ownership of outstanding common stock in Columns (A)
      and (B) above before and after the sale of shares registered hereunder is
      based on the fully diluted number of shares of common stock outstanding
      assuming the exercise of all warrants and options held by the selling
      stockholder and registered hereunder, and taking into account conversion
      of all of our series C convertible preferred stock at a conversion price
      of $1.55 per share.


 (3)  The selling security holder is an employee of Dougherty & Company, LLC,
      the placement agent in our private placement of series C preferred stock.


 (4)  The selling security holder is a member of the immediate family of an
      employee of Dougherty & Company, LLC.


 (5)  The selling security holder beneficially owns greater than 5% of our
      common stock.


 (6)  The selling security holder is a principal of Dougherty & Company, LLC,
      the placement agent in the private placement of series C preferred stock.


 (7)  The selling security holder beneficially owns greater than 5% of our
      common stock.


 (8)  The selling security holder is an affiliate of and under common control
      with Venturetec, Inc. BVI, and together with Venturetec beneficially owns
      greater than 5% of our common stock.


 (9)  Includes warrants to purchase 9,320 shares of common stock previously
      owned by the selling security holder. The shares underlying those
      warrants are not registered on this registration statement.


(10)  Includes 63,855 shares of common stock previously owned by the selling
      security holder and not registered on this registration statement.


(11)  Includes 6,720 shares of common stock previously owned by the selling
      security holder and not registered on this registration statement.


(12)  Includes 38,080 shares of common stock previously owned by the selling
      security holder and not registered on this registration statement.


(13)  Includes 25,760 shares of common stock previously owned by the selling
      security holder and not registered on this registration statement.


(14)  Includes 373,521 shares of common stock previously owned by the selling
      security holder and 33,654 shares of common stock issuable upon the
      exercise of warrants held by Peter Friedli, an affiliate of Venturetec,
      for a total of 407,175 shares of common stock not registered on this
      registration statement.


(15)  Includes 1,320 shares of common stock previously owned by the selling
      security holder and not registered on this registration statement.


(16)  Includes 160,160 shares of common stock previously owned by the selling
      security holder and not registered on this registration statement.


                                       19



(17)  Includes 63,855 shares of common stock previously owned by the selling
      security holder and not registered on this registration statement.


(18)  Includes 2,000 shares of common stock previously owned by the selling
      security holder and not registered on this registration statement.


(19)  Includes 22,429 shares of common stock previously owned by the selling
      security holder and not registered on this registration statement.


(20)  Includes 89,273 shares of common stock previously owned by the selling
      security holder and not registered on this registration statement.


(21)  Includes 2,000 shares of common stock previously owned by the selling
      security holder and not registered on this registration statement.


(22)  Includes 2,500 shares of common stock previously owned by the selling
      security holder and not registered on this registration statement.


(23)  Includes 5,000 shares of common stock previously owned by the selling
      security holder and not registered on this registration statement.


(24)  Includes 589,363 shares of common stock previously owned by the selling
      security holder and not registered on this registration statement and
      199,253 shares of common stock previously owned by the selling security
      holder and registered on this registration statement.


(25)  Based solely on information provided to us by the selling security
      holder, voting control and investment power over the shares is held by
      Zesiger Capital Group LLC, an investment advisory firm. Voting control
      and investment power of Zesiger Capital Group LLC is exercised by or at
      the direction of any of its managing members. The managing members of
      Zesiger Capital Group LLC are Albert L. Zesiger, Barrie R. Zesiger, Lisa
      W. Hess, James F. Cleary and John J. Kayola.


(26)  Based solely on information provided to us by the selling security
      holder, voting control and investment power over the shares is held by
      Daniel Asher.


(27)  Based solely on information provided to us by the selling security
      holder, voting control and investment power over the shares is held by
      Daniel Asher and Nathan Fischel.


(28)  Based solely on information provided to us by the selling security
      holder, voting control and investment power over the shares is held by
      Stewart Flink and Gary Elkins.


(29)  Based solely on information provided to us by the selling security
      holder, voting control and investment power over the shares is held by
      Peter E. Salas.


(30)  The selling security holder acted as the placement agent for our series C
      preferred stock private placement. Based solely on information provided
      to us by the selling security holder, voting control and investment power
      over the shares is held by Gerald Kraut.


(31)  Based solely on information provided to us by the selling security
      holder, voting control and investment power over the shares is held by
      Richard L. Abrahams.


(32)  Based solely on information provided to us by the selling security
      holder, voting control and investment power over the shares is held by
      Irvin R. Kessler.


(33)  Based solely on information provided to us by the selling security
      holder, voting control and investment power over the shares is held by
      James E. Lineberger and James E. Lineberger, Jr.


(34)  Based solely on information provided to us by the selling security
      holder, voting control and investment power over the shares is held by
      Ira Leventhal and Kevin Heneghan.


(35)  Based solely on information provided to us by the selling security
      holder, voting control and investment power over the shares is held by
      Peter Friedli. Mr. Friedli individually beneficially owns greater than 5%
      of our common stock.


(36)  Based solely on information provided to us by the selling security
      holder, voting control and investment power over the shares is held by
      Mark Shoom.


(37)  The Peregrine Fund, L.P. is controlled by Pepper Hamilton LLP, counsel to
      the Company. Voting control and investment power over the shares is held
      by a management committee comprised of James L. Murray, Barry M. Abelson,
      Robert L. Hickok, Gilberto M. Villacorta and Michael B. Staebler.


                                       20






                              PLAN OF DISTRIBUTION

  We are registering the common stock covered by this prospectus for selling
stockholders. As used in this prospectus, "selling stockholders" includes the
donees, pledgees, transferees or others who may later hold the selling
stockholders' shares of common stock registered herein. We will pay the costs,
expenses and fees in connection with registering the common stock, but the
selling stockholders will pay any brokerage commissions, discounts or other
expenses attributable to the sale of common stock.

  The selling stockholders may sell the common stock from time to time in one
or more types of transactions (which may include block transactions), on the
American Stock Exchange, in negotiated transactions, through put or call option
transactions relating to the shares, through or a combination of such methods
of sale, at market prices prevailing at the time of sale, or at negotiated
prices. Such transactions may or may not involve brokers or dealers.

  The selling stockholders may effect such transactions by selling shares
directly to purchasers or to or through broker-dealers, which may act as agents
or principals. Such broker-dealers may receive compensation in the form of
discounts, concessions, or commissions from the selling stockholders and/or the
purchasers of shares for whom such broker-dealers may act as agents or to whom
they sell as principal, or both (which compensation as to a particular broker-
dealer might be in excess of customary commissions).

  The selling stockholders and any broker-dealers that act in connection with
the sale of shares might be deemed to be "underwriters" within the meaning of
Section 2(11) of the Securities Act, and any commissions received by such
broker-dealers and any profit on the resale of the shares sold by them while
acting as principals might be deemed to be underwriting discounts or
commissions under the Securities Act. The selling stockholders may agree to
indemnify any agent, dealer or broker-dealer that participates in transactions
involving sales of the shares against certain liabilities, including
liabilities arising under the Securities Act.

  Because selling stockholders may be deemed to be "underwriters" within the
meaning of Section 2(11) of the Securities Act, the selling stockholders will
be subject to the prospectus delivery requirements of the Securities Act. We
have informed the selling stockholders that the anti-manipulative provisions of
Regulation M promulgated under the Exchange Act may apply to their sales in the
market.

  Selling stockholders also may resell all or a portion of the shares in open
market transactions in reliance upon Rule 144 under the Securities Act,
provided they meet the criteria and conform to the requirements of such Rule.



  If a selling stockholder notifies us that they have entered into or will
enter into any material arrangement with a broker or dealer for the sale of
shares of common stock through a block trade, special offering, exchange
distribution or secondary distribution or a purchase by a broker or dealer, a
supplement to this prospectus will be filed, if required, pursuant to Rule
424(b) under the Securities Act, as soon as practicable, but in no event later
than two business days after the arrangement has been entered into. This
supplement will disclose:


  .  the name of each such selling stockholder and of the participating
     brokers or dealers;


  .  the number of shares of common stock involved;


  .  the price at which such shares were or will be sold;


  .  the commissions paid or to be paid or discounts or concessions allowed
     or to be allowed to such brokers or dealers, where applicable;


                                       21



  .  if applicable, that such brokers or dealers did not and will not conduct
     any investigation to verify the information set out or incorporated by
     reference in this prospectus; and


  .  other facts material to the transaction.


  In addition, if a selling stockholder notifies us that a donee, pledgee or
other transferee intends to sell more than 500 shares of common stock, we will
file a supplement to this prospectus.


                                       22


                                 LEGAL MATTERS

  The validity of the common stock offered hereby will be passed upon for us by
Pepper Hamilton LLP.

                                       23


                                    EXPERTS

  The December 31, 2000 financial statements incorporated by reference in this
prospectus and elsewhere in the registration statement have been audited by
Arthur Andersen LLP, independent public accountants, as indicated in their
report with respect thereto, and are included herein in reliance upon the
authority of said firm as experts in giving said report. Reference is made to
said report, which includes an explanatory paragraph with respect to the
uncertainty regarding the Company's ability to continue as a going concern as
discussed in Note 1 to the financial statements.

                                       24


                       WHERE YOU CAN GET MORE INFORMATION

  Our fiscal year ends on December 31. We file annual, quarterly and current
reports, proxy statements and other information with the Securities and
Exchange Commission (the "Commission" or "SEC"). You may read and copy any
reports, statements or other information on file at the SEC's public reference
room in Washington, D.C. You can request copies of those documents, upon
payment of a duplicating fee, by writing to the SEC. Our SEC filings are also
available to the public at the SEC Internet site at http://www.sec.gov.

  We have filed a registration statement on Form S-3 with the SEC. This
prospectus, which forms a part of the registration statement, does not contain
all of the information included in the registration statement. Certain
information is omitted. You should refer to the registration statement and its
exhibits. With respect to references made in this prospectus to any contract or
other document relating to us, such references are not necessarily complete.
You should refer to the exhibits attached to the registration statement for
copies of the actual contract or document. You may review a copy of the
registration statement at the SEC's public reference room in Washington, D.C.,
and at the SEC's regional offices in Chicago, Illinois and New York, New York.
Please call the SEC at 1-800-SEC-0330 for further information on the operation
of the public reference rooms. Our SEC filings, including the registration
statement, can also be reviewed by accessing the SEC's Internet site at
http://www.sec.gov.

                INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

  The following documents filed by Careside with the Commission are
incorporated in this prospectus by reference:


  .  Careside's Annual Report on Form 10-K/A for the fiscal year ended
     December 31, 2000.


  .  Careside's Quarterly Report on Form 10-Q/A for the quarter ended March
     31, 2001.


  .  The description of the common stock contained in Careside's Registration
     Statement on Form S-1 (Registration No. 333-69207) dated December 18,
     1998, including any amendments or reports filed for the purpose of
     updating such description, and the Post-Effective Amendment No. 1 on
     Form S-3 to Form S-1, dated September 27, 2000.


  .  Careside's Registration Statement on Form 8-A filed on May 28, 1999
     describing the terms, rights and provisions applicable to the common
     stock.


  .  In addition, all documents subsequently filed by Careside pursuant to
     Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act prior to the
     termination of the offering shall be deemed to be incorporated by
     reference herein from their respective dates of filing.


  All financial statements included in the above-referenced filings should be
read in conjunction with the Risk Factors section of this prospectus.


  Any statements contained in a document incorporated or deemed to be
incorporated by reference herein shall be deemed to be modified or superseded
for purposes of this prospectus to the extent that a statement contained herein
or in any other subsequently filed document which also is incorporated or
deemed to be incorporated by reference herein modifies or supersedes such
statement. Any such statement so modified or superseded shall not be deemed,
except as so modified or superseded, to constitute a part of this Prospectus.

                                       25



  You may also request a copy of these filings, at no cost, by writing or
telephoning Careside at the following address:


    Careside, Inc.


    6100 Bristol Parkway


    Culver City, California 90230


    Telephone: (310) 338-6767


                                       26


--------------------------------------------------------------------------------
--------------------------------------------------------------------------------


                                [LOGO OF CARESIDE]

                     14,195,890 Shares of Common Stock


                               ----------------

                                   PROSPECTUS

                               ----------------

                              August 8, 2001



  We have not authorized any dealer, salesperson or other person to give any
information or represent anything not contained in this prospectus. You must
not rely on any unauthorized information. This prospectus does not offer to
sell or buy any securities in any jurisdiction where it is unlawful. The
information in this prospectus is current as of its date.

--------------------------------------------------------------------------------
--------------------------------------------------------------------------------


                                    PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14. Other Expenses of Issuance and Distribution.

  The following table sets forth an itemization of all estimated expenses, in
connection with sale of the securities being registered payable by Careside:



     Nature of Expense                                                 Amount
     -----------------                                               ----------
                                                                  
     SEC Registration Fee........................................... $ 8,744.08
     Printing and engraving fees.................................... $        0
     Registrant's counsel fees and expenses......................... $   10,000
     Accounting fees and expenses................................... $    5,000
     Miscellaneous.................................................. $    5,000
                                                                     ----------
       TOTAL........................................................ $28,744.08


Item 15. Indemnification of Directors and Officers.

  Our Amended and Restated Certificate of Incorporation (the "Charter")
provides that we shall indemnify and advance expenses to the fullest extent
permitted by Section 145 of the Delaware General Corporation Law ("DGCL"), as
amended from time to time, to each person who is or was one of our directors or
officers and the heirs, executors and administrators of such a person. Any
expenses, including attorneys' fees, incurred by a person who is or was one of
our directors or officers, and the heirs, executors and administrators of such
a person in connection with defending any such proceeding in advance of its
final disposition shall be paid by us; provided, however, that if the DGCL
requires, an advancement of expenses incurred by an indemnitee in his capacity
as a director or officer, and not in any other capacity in which service was or
is rendered by such indemnitee, including, without limitation, service to an
employee benefit plan, such be made only upon delivery to us of an undertaking
by or on behalf of such indemnitee, to repay all amounts so advanced, if it
shall ultimately be determined that such indemnitee is not entitled to be
indemnified for such expenses. Notwithstanding the aforementioned
indemnification provisions, we may, at the discretion of our Chief Executive
Officer, enter into indemnification agreements with directors or officers.

  Section 145 of the DGCL provides that a corporation has the power to
indemnify any director or officer, or former director or officer, who was or is
a party or is threatened to be made a party to any threatened, pending or
completed action, suit or proceeding, whether civil, criminal, administrative
or investigative, other than an action by or in the right of the corporation,
by reason of the fact that such director or officer or former director or
officer is or was a director, officer, employee or agent of the corporation,
against expenses, including attorneys' fees, judgments, fines and amounts paid
in settlement actually and reasonably incurred by them in connection with such
action, suit or proceeding, if such person shall have acted in good faith and
in a manner reasonably believed to be in or not opposed to the best interests
of the corporation, and, with respect to any criminal action or proceeding,
provided that such person had no reasonable cause to believe his or her conduct
was unlawful, except that, if such action shall be in the right of the
corporation, no such indemnification shall be provided as to any claim, issue
or matter as to which such person shall have been judged to have been liable to
the corporation unless and to the extent that the Court of Chancery of the
State of Delaware, or any court in which such suit or action was brought, shall
determine upon application that, in view of all of the circumstances of the
case, such person is fairly and reasonably entitled to indemnify for such
expenses as such court shall deem proper.

                                      II-1


  The Charter contains a provision to limit the personal liability of our
directors to the fullest extent permitted by Section 102(b)(7) of the DGCL, as
amended. In addition, the Amended and Restated By-Laws provide that we shall
indemnify any person who was or is a party or is threatened to be made a party
to any threatened, pending or completed action, suit or proceeding, whether
civil, criminal, administrative or investigative, other than an action by us or
in our right, by reason of the fact that he is or was one of our directors,
officers, employees or agents, or is or was serving at our request as a
director, officer, employee or agent of another corporation, partnership, joint
venture, trust or other enterprise, against expenses, including attorneys'
fees, judgments, fines and amounts paid in settlement actually and reasonably
incurred by him in connection with such action, suit or proceeding if he acted
in good faith and in a manner he reasonably believed to be in or not opposed to
our best interests, and, with respect to any criminal action or proceeding, had
no reasonable cause to believe his conduct was unlawful.

  As permitted by the DGCL, the Charter provides that, subject to certain
limited exceptions, none of our directors shall be liable to us or our
stockholders for monetary damages for breach of fiduciary duty as a director,
except for liability (1) for any breach of the director's duty of loyalty to us
or our stockholders, (2) for acts or omissions not in good faith or which
involve intentional misconduct or a knowing violation of law, (3) for the
unlawful payment of dividends on or redemption or repurchase of our capital
stock or (4) for any transaction from which the director derived an improper
personal benefit. The effect of this provision is to limit our ability and our
stockholders' ability through stockholder derivative suits on our behalf, to
recover monetary damages against a director for the breach of certain fiduciary
duties as a director, including breaches resulting from grossly negligent
conduct. In addition, the Charter and Amended and Restated By-Laws provide that
we shall, to the fullest extent permitted by the DGCL, indemnify all of our
directors and officers and that we may, to the extent permitted by the DGCL,
indemnify our employees and agents.

Item 16. Exhibits



 Exhibit No.                             Description
 -----------                             -----------
          
  4.1        Certificate of Designations of Series C Convertible Preferred
             Stock.*

  4.2        Form of Securities Purchase and Subscription Agreement dated as of
             March 29, 2001 by and between Careside, Inc. and Purchasers.*

  4.3        Form of Warrant Agreement dated as of March 29, 2001 executed by
             Careside, Inc. and addressed to Purchasers (including Warrant
             Certificates).*

  5.1        Opinion of Pepper Hamilton LLP

 23.1        Consent of Arthur Andersen LLP

--------
* Incorporated herein by reference to Careside's Quarterly Report on Form 10-Q
  for the quarterly period ended March 31, 2001 filed on May 15, 2001 (SEC File
  Number 001-15051).

Item 17. Undertakings.

  Insofar as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers and controlling persons of the
registrant pursuant to the foregoing provisions, or otherwise, the registrant
has been advised that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Securities
Act and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling
precedent, submit to a court of appropriate jurisdiction the question whether
such indemnification by it is against public policy as expressed in the
Securities Act and will be governed by the final adjudication of such issue.

                                      II-2



  The undersigned registrant hereby undertakes:


    To file during any period in which offers or sales are being made, a
  post-effective amendment to this registration statement to:


      To include any prospectus required by Section 10(a)(3) of the
    Securities Act of 1933, as amended (the "Securities Act");


      To reflect in the prospectus any facts or events arising after the
    effective date of the registration statement (or the most recent post-
    effective amendment thereof) which, individually or in the aggregate,
    represent a fundamental change in the information set forth in the
    registration statement. Notwithstanding the foregoing, any increase or
    decrease in volume of securities offered (if the dollar value of the
    securities offered would not exceed that which was registered) and any
    deviation from the low or high end of the estimated maximum offering
    range may be reflected in the form of prospectus filed with the
    Commission pursuant to Rule 424(b) if, in the aggregate, the changes in
    volume and price represent no more than a 20% change in the maximum
    aggregate offering price set forth in the "Calculation of Registration
    Fee" table in the effective registration statement, and


      To include additional or changed material information on the plan of
    distribution not previously disclosed in the registration statement or
    any material change to such information in the registration statement.


    That, for purposes of determining liability under the Securities Act,
  each post-effective amendment shall be deemed to be a new registration
  statement relating to the securities offered, and the offering of the
  securities at that time to be the initial bona fide offering thereof.


    To remove from registration by means of a post-effective amendment any of
  the securities being registered which remain unsold at the termination of
  the offering.




    That, for purposes of determining any liability under the Securities Act,
  each filing of the registrant's annual report pursuant to Section 13(a) or
  15(d) of the Securities Exchange Act of 1934 (and, where applicable, each
  filing of an employee benefit plan's annual report pursuant to Section
  15(d) of the Securities Exchange Act of 1934) that is incorporated by
  reference in the registration statement shall be deemed to be a new
  registration statement relating to the securities offered therein, and the
  offering of such securities at that time shall be deemed to be the initial
  bona fide offering thereof.


  In addition, the undersigned registrant hereby undertakes to provide to the
underwriters at the closing specified in the underwriting agreements,
certificates in such denominations and registered in such names as required by
the underwriters to permit prompt delivery to each purchaser.

                                     II-3



                                SIGNATURES


  Pursuant to the requirements of the Securities Act of 1933, as amended, the
registrant certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form S-3 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized in Culver City, California, on this 9th day of August, 2001.


                                          Careside, Inc.


                                               /s/ W. Vickery Stoughton


                                          By: ____________________________


                                                 W. Vickery Stoughton


                                            Chairman of the Board of Directors
                                             and Chief Executive Officer


                             POWER OF ATTORNEY


  KNOW ALL MEN BY THESE PRESENTS, that each individual whose signature appears
below constitutes and appoints W. Vickery Stoughton, Thomas H. Grove, and James
R. Koch and each of them, his true and lawful attorney-in-fact and agents, with
full power of substitution, for him and in his name, place and stead, in any
and all capacities to sign any and all amendments (including post-effective
amendments) to this Registration Statement, and to sign any registration
statement for the same offering covered by this Registration Statement that is
to be effective upon filing pursuant to Rule 462(b) promulgated under the
Securities Act of 1933, and all post-effective amendments thereto, and to file
the same, with all exhibits thereto and all documents in connection therewith,
with the Securities and Exchange Commission, granting unto said attorneys-in-
fact and agents full power and authority to do and perform each and every act
and thing requisite and necessary to be done in and about the premises, as
fully to all intents and purposes as he might or could do in person, hereby
ratifying and confirming all that said attorneys-in-fact and agents, on his or
their substitute or substitutes, may lawfully do or cause to be done by virtue
hereof.


  Pursuant to the requirements of the Securities Act of 1933, as amended, this
Registration Statement has been signed by the following persons in the
capacities and on the dates indicated:





              Signature                          Title                   Date
              ---------                          -----                   ----

                                                            
     /s/ W. Vickery Stoughton          Chairman of the Board of      June 8, 2001
______________________________________  Directors, Chief
         W. Vickery Stoughton           Executive Officer and
                                        Director (principal
                                        executive officer)

      /s/ Anthony P. Brenner           Director                      June 8, 2001
______________________________________
          Anthony P. Brenner

      /s/ William F. Flatley           Director                      June 9, 2001
______________________________________
          William F. Flatley

     /s/ S. Kenneth N. Kermes          Director                      June 6, 2001
______________________________________
         S. Kenneth N. Kermes

      /s/ C. Alan MacDonald            Director                      June 8, 2001
______________________________________
          C. Alan MacDonald

        /s/ Diana Mackie               Director                      June 5, 2001
______________________________________
             Diana Mackie

          /s/ James R. Koch            Executive Vice President,    August 8, 2001
______________________________________  Chief Financial Officer,
            James R. Koch               Treasurer and principal
                                        accounting officer



                                      II-4