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As filed with the Securities and Exchange Commission on June 17, 2004

Registration No. 333-________



SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549
______________________

FORM S-8

REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
______________________

TARGETED GENETICS CORPORATION

(Exact name of Registrant as specified in its charter)
     
Washington
(State or other jurisdiction of incorporation or organization)
  91-1549568
(I.R.S. Employer Identification No.)

1100 Olive Way, Suite 100
Seattle, Washington 98101

(Address of principal executive offices, including zip code)

TARGETED GENETICS CORPORATION
1999 STOCK OPTION PLAN

(Full title of the plan)

H. STEWART PARKER
President and Chief Executive Officer
Targeted Genetics Corporation
1100 Olive Way, Suite 100
Seattle, Washington 98101
(206) 623-7612

(Name, address and telephone number, including area code, of agent for service)
______________________
Copies to:

     
Stephen M. Graham, Esq.
Eric S. Carnell, Esq.
Orrick, Herrington & Sutcliffe LLP
719 Second Avenue, Suite 900
Seattle, Washington 98104
(206) 839-4300
  Jonathan K. Wright, Esq.
General Counsel
Targeted Genetics Corporation
1100 Olive Way, Suite 100
Seattle, Washington 98101
(206) 623-7612

______________________

CALCULATION OF REGISTRATION FEE

                                 
 
                    Proposed Maximum        
  Title of Securities     Number to Be     Proposed Maximum     Aggregate Offering     Amount of  
  to Be Registered     Registered(1)     Offering Price Per Share(2)     Price(2)     Registration Fee  
 
Common Stock, par value $0.01 per share, authorized but unissued under the 1999 Stock Option Plan, as amended
    6,000,000     $1.575     $9,450,000     $ 1,198    
 
(1)   This registration statement shall also cover any additional shares of common stock that may become issuable under the 1999 Stock Option Plan, as amended, being registered hereby as a result of any future stock split, stock dividend, recapitalization or similar adjustment effected without the receipt of consideration that results in an increase in the number of outstanding shares of the registrant’s common stock.
 
(2)   Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) under the Securities Act of 1933, as amended. The price per share is estimated to be $1.575, based on the average of the high and low prices of the registrant’s common stock on June 16, 2004, as reported on the NASDAQ SmallCap Market.

 


TABLE OF CONTENTS

Item 8. EXHIBITS
SIGNATURES
INDEX TO EXHIBITS
EXHIBIT 5.1
EXHIBIT 10.1
EXHIBIT 23.1


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REGISTRATION OF ADDITIONAL SECURITIES

     This registration statement on Form S-8 is being filed by Targeted Genetics Corporation, or Targeted Genetics, for the purpose of registering an additional 6,000,000 shares of common stock, par value $0.01 per share, issuable by Targeted Genetics pursuant to the Targeted Genetics Corporation 1999 Stock Option Plan, as amended, or the 1999 Plan, as amended and restated March 22, 2004. Pursuant to General Instruction E of Form S-8, we incorporate by reference into this registration statement the contents of our registration statement on Form S-8 relating to the 1999 Plan that we filed with the Securities and Exchange Commission on May 14, 1999, file number 333-78523, and that remains effective.

Item 8. EXHIBITS

         
Exhibit    
Number
  Description
    5.1    
Opinion of Orrick, Herrington & Sutcliffe LLP regarding the legality of the common stock being registered
  10.1    
Targeted Genetics Corporation 1999 Stock Option Plan, as amended and restated March 22, 2004
  23.1    
Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm
  23.2    
Consent of Orrick, Herrington & Sutcliffe LLP (included in Exhibit 5.1)
  24.1    
Power of Attorney (included in signature page)

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SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Seattle, state of Washington, on this 17th day of June, 2004.

         
  TARGETED GENETICS CORPORATION
 
 
  By:   /s/ H. STEWART PARKER    
    H. STEWART PARKER   
    PRESIDENT AND CHIEF EXECUTIVE OFFICER   
 

POWER OF ATTORNEY

     Each person whose signature appears below constitutes and appoints H. Stewart Parker and Todd E. Simpson, or either of them, as attorneys-in-fact with full power of substitution, to execute in the name and on the behalf of each person, individually and in each capacity stated below, and to file, any and all amendments to this registration statement, including any and all post-effective amendments.

     Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities indicated below on this 17th day of June, 2004.

     
Signature
  Title
/S/ H. STEWART PARKER

H. STEWART PARKER
  President, Chief Executive Officer (Principal
Executive Officer) and Director
/S/ TODD E. SIMPSON

TODD E. SIMPSON
  Vice President, Finance and Administration,
Chief Financial Officer, Secretary and
Treasurer (Principal Financial and Accounting
Officer)
/S/ JEREMY L. CURNOCK COOK

JEREMY L. CURNOCK COOK
  Chairman of the Board and Director
/S/ JACK L. BOWMAN

JACK L. BOWMAN
  Director
/S/ JOSEPH M. DAVIE

JOSEPH M. DAVIE
  Director
/S/ LOUIS P. LACASSE

LOUIS P. LACASSE
  Director

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/S/ NELSON L. LEVY

NELSON L. LEVY, PH.D., M.D.
  Director
/S/ MARK H. RICHMOND

MARK H. RICHMOND, PH.D
  Director

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INDEX TO EXHIBITS

         
Exhibit    
Number
  Description
    5.1    
Opinion of Orrick, Herrington & Sutcliffe LLP regarding the legality of the common stock being registered
  10.1    
Targeted Genetics Corporation 1999 Stock Option Plan, as amended and restated March 22, 2004
  23.1    
Consent of Ernst & Young LLP, Independent Registered Public Accounting Firm
  23.2    
Consent of Orrick, Herrington & Sutcliffe LLP (included in Exhibit 5.1)
  24.1    
Power of Attorney (included in signature page)

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