SECURITIES AND EXCHANGE COMMISSION

                              Washington, D.C. 2049
                   ___________________________________________

                       SCHEDULE 13D/A2 (Amendment No. 2)*
                    Under the Securities Exchange Act of 1934

                          Targeted Genetics Corporation
--------------------------------------------------------------------------------
                                (Name of Issuer)

                     Common Stock, par value $.01 per share
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    87612M108
--------------------------------------------------------------------------------
                                 (CUSIP Number)

                                William F. Daniel
                              Elan Corporation, plc
                                  Lincoln House
                                  Lincoln Plaza
                                Dublin 2, Ireland
                                (353) 1-709-4000
--------------------------------------------------------------------------------
           (Name, Address and Telephone Number of Person Authorized to
                       Receive Notices and Communications)

                                 March 31, 2004
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition that is the subject of this Schedule 13D, and is filing this
schedule because of ss.ss. 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the
following box [ ].

NOTE: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See Rule 240.13d-7 for other
parties to whom copies are to be sent.

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).




                                  Page 1 of 12





--------------------------------------------------------------------------------
CUSIP No.  249908-10-4
--------------------------------------------------------------------------------
(1) NAME OF REPORTING PERSONS
    Elan Corporation, plc
    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (entities only)
    N/A
--------------------------------------------------------------------------------
(2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
    (a) [ ]
    (b) [ ]
--------------------------------------------------------------------------------
(3) SEC USE ONLY

--------------------------------------------------------------------------------
(4) SOURCE OF FUNDS (See Instructions)
    WC, OO
--------------------------------------------------------------------------------
(5) CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
    ITEMS 2(d) or 2(e)  [  ]
--------------------------------------------------------------------------------
(6) CITIZENSHIP OR PLACE OF ORGANIZATION
    Ireland
--------------------------------------------------------------------------------
Number of         (7)    SOLE VOTING POWER
Shares                   0
--------------------------------------------------------------------------------
Beneficially      (8)    SHARED VOTING POWER
Owned                    12,064,882
--------------------------------------------------------------------------------
by Each           (9)    SOLE DISPOSITIVE POWER
Reporting                0
--------------------------------------------------------------------------------
Person With       (10)   SHARED DISPOSITIVE POWER
                                   12,064,882
--------------------------------------------------------------------------------
(11) AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
     12,064,882
--------------------------------------------------------------------------------
(12) CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
     (See Instructions)  [  ]
--------------------------------------------------------------------------------
(13) PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
     14.8%
--------------------------------------------------------------------------------
(14) TYPE OF REPORTING PERSON (See Instructions)
     CO
--------------------------------------------------------------------------------



                                  Page 2 of 12



--------------------------------------------------------------------------------
CUSIP No.  249908-10-4
--------------------------------------------------------------------------------
(1)   NAME OF REPORTING PERSONS Elan International Services, Ltd.
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (entities only)
      N/A
--------------------------------------------------------------------------------
(2)   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
      (a) [ ]
      (b) [ ]
--------------------------------------------------------------------------------
(3)   SEC USE ONLY

--------------------------------------------------------------------------------
(4)   SOURCE OF FUNDS (See Instructions)
      WC, OO
--------------------------------------------------------------------------------
(5)   CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
      ITEMS 2(d) or 2(e)  [  ]
--------------------------------------------------------------------------------
(6)   CITIZENSHIP OR PLACE OF ORGANIZATION
      Bermuda
--------------------------------------------------------------------------------
Number of         (7)    SOLE VOTING POWER
Shares                   0
--------------------------------------------------------------------------------
Beneficially      (8)    SHARED VOTING POWER
Owned                    12,064,882
--------------------------------------------------------------------------------
by Each           (9)    SOLE DISPOSITIVE POWER
Reporting                0
--------------------------------------------------------------------------------
Person With       (10)   SHARED DISPOSITIVE POWER
                         12,064,882
--------------------------------------------------------------------------------
(11)  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
      12,064,882
--------------------------------------------------------------------------------
(12)  CHECK IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
      (See Instructions)  [  ]
--------------------------------------------------------------------------------
(13)  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
      14.8%
--------------------------------------------------------------------------------
(14)  TYPE OF REPORTING PERSON (See Instructions)
      CO
--------------------------------------------------------------------------------



                                  Page 3 of 12



Item 1.  Security and Issuer.

     Item 1 of the Schedule  13D is hereby  amended and restated in its entirety
as follows:

     This  Amendment No. 2 amends the Schedule 13D filed with the Securities and
Exchange  Commission (the  "Commission") on August 9, 1999 by Elan International
Services,  Ltd.  ("EIS"),  a Bermuda  exempted  limited  liability  company  and
wholly-owned  subsidiary  of Elan  Corporation,  plc  ("Elan"),  an Irish public
limited company,  as amended by the Schedule 13D/A1 filed with the Commission on
November 5, 2003 (the  "Schedule  13D"),  with respect to the Common Stock,  par
value $.01 per share (the "Common Stock"), of Targeted Genetics Corporation (the
"Issuer"),  a Washington corporation whose principal offices are located at 1100
Olive Way, Suite 100, Seattle, Washington 98101.

Item 2.  Identity and Background.

     Item 2 of the Schedule  13D is hereby  amended and restated in its entirety
as follows:

     This  Schedule  13D is filed by Elan and  EIS.  Elan's  principal  place of
business is Lincoln House, Lincoln Place Dublin 2, Ireland.  Elan is a worldwide
pharmaceutical  company.  EIS's  principal  place of business  is 102 St.  James
Court, Flatts, Smiths, FL 04 Bermuda. EIS is an investment holding company.

     Schedule A to this  Schedule 13D sets forth the (a) name,  (b) residence or
business address,  (c) present principal  occupation or employment and the name,
principal business and address of any corporation or other organization in which
such  employment is conducted and (d)  citizenship or place of  organization  of
each executive officer, director and controlling person of Elan and EIS.

     During the last five years,  neither Elan, EIS nor any person identified on
Schedule A to this Schedule 13D: (i) has been convicted in a criminal proceeding
(excluding traffic violations or similar misdemeanors); or (ii) was a party to a
civil proceeding of a judicial or administrative body of competent jurisdiction,
as a result of which  proceeding  it was or is subject to a judgment,  decree or
final  order  enjoining  future  violations  of,  or  prohibiting  or  mandating
activities  subject to,  United  States  federal or state  securities  laws,  or
finding any violation with respect to such laws.

Item 3.  Source and Amount of Funds or Other Consideration.

     Item 3 of the Schedule  13D is hereby  amended and restated in its entirety
as follows:

     Pursuant  to a  Securities  Purchase  Agreement  dated July 21, 1999 by and
among  Elan and EIS,  on the one hand,  and the  Issuer,  on the other hand (the
"Securities  Purchase  Agreement"),  EIS acquired (a) 2,148,899 shares of Common
Stock of the Issuer for  consideration  of  $5,000,000  and (b) 12,015 shares of
Series B Convertible  Exchangeable  Preferred  Stock,  $0.01 par value per share
(the  "Series  B  Preferred   Stock"),   of  the  Issuer  for  consideration  of
$12,015,000.  The source of the funds  used in  acquiring  the  above-referenced
securities was working capital.

     Pursuant to its terms, the Series B Preferred Stock accrued dividends until
July 21,  2005 at an  annual  rate of 7.0% of  $1,000  per  share  plus  accrued
dividends  thereon,  compounded  semi-annually,   payable  by  the  issuance  of
additional  shares of Common  Stock upon  conversion  of the Series B  Preferred
Stock.  Each share of Series B Preferred Stock was convertible,  without payment
of any additional  consideration  by the holder and at the option of the holder,
into  such  number  of fully  paid and  nonassessable  shares  of  Common  Stock
determined  by  dividing  $1,000  plus any  accrued  and unpaid  dividends  by a
conversion  price of $3.32 per  share of  Common  Stock,  subject  to  customary
antidilution  adjustments.  As of March 31, 2004,  the Series B Preferred  Stock
plus accrued  dividends was convertible into an aggregate of 4,993,946 shares of
Common Stock.



                                  Page 4 of 12


     At the time of entering into the Securities Purchase Agreement,  the Issuer
and Elan formed Emerald Gene Systems, Ltd.  ("Emerald"),  pursuant to which they
entered into a joint venture relationship (the "Joint Venture").

     On March 31, 2004 (the "Effective Date"),  Elan, Elan Pharma  International
Limited ("EPIL"),  EIS, the Issuer and Emerald executed a Termination  Agreement
(the  "Termination  Agreement"),  pursuant  to which,  among other  things,  (i)
certain  agreements  relating to the Joint  Venture  were  terminated,  (ii) EIS
agreed to convert on the  Effective  Date the Series B Preferred  Stock plus all
accrued and unpaid dividends  thereon and (iii) in consideration  for the Issuer
agreeing to certain  amendments to the  contractual  restrictions  governing the
transfer of the Common Stock held by EIS,  described in Item 6 below, EIS agreed
to waive the right to receive upon  conversion of the Series B Preferred  Stock,
and accrued and unpaid dividends thereon any shares of Common Stock in excess of
4,330,000 shares.

     Upon the  exercise  by the  Issuer of a right to  require  EIS to  purchase
additional shares of Common Stock pursuant to the Securities Purchase Agreement,
on August 9, 2000, EIS acquired 382,739 shares of Common Stock of the Issuer for
consideration  of  $5,000,000.  The source of the funds used in acquiring  these
shares of Common Stock of the Issuer was working capital.

     In addition,  pursuant to the  Securities  Purchase  Agreement,  the Issuer
issued to EIS a convertible  promissory note in an aggregate principal amount of
up  to  $12,015,000  (the   "Convertible   Note").   The  Convertible  Note  was
subsequently  transferred to Elan Pharma International  Limited, an affiliate of
EIS  and  wholly-owned  subsidiary  of  Elan,  but  the  right  to  convert  the
Convertible  Note and receive Common Stock upon  conversion was retained by EIS.
The  Issuer  made  draw-downs  in the  aggregate  amount of  $7,950,000,  on the
following dates and in the following  amounts:  September 26, 2001 ($2,000,000),
April 25,  2002  ($2,000,000),  June 28, 2002  ($3,000,000),  and August 9, 2002
($950,000).  Interest on each  drawdown of the  Convertible  Note  accrued at an
annual  rate of  12.0%,  compounded  on  each  semi-annual  anniversary  of such
drawdown. At the Issuer's option,  accrued interest was capitalized and added to
the principal amount  outstanding on each compounding date. The Convertible Note
had a stated maturity of July 21, 2005.  Each tranche  (consisting of a drawdown
or accrual of  interest) of the  Convertible  Note was  convertible  at any time
prior to  repayment in full into a number of shares of Common Stock equal to the
principal  amount of such  tranche and all accrued and unpaid  interest  thereon
divided by a per share  price  calculated  as 150% of the average of the closing
price of the Common Stock for the 60 trading days ending two business days prior
to the date that the tranche was  requested  by the Issuer.  As of  September 2,
2003, the date of repayment of the Convertible  Note, the  Convertible  Note was
convertible at the option of the holder into  5,203,243  shares of Common Stock.
In addition,  the Convertible Note was prepayable at the option of the Issuer on
a per tranche  basis by the issuance of a number of shares of Common Stock equal
to the outstanding  principal amount of such tranche and any and all accrued and
unpaid  interest  thereon  divided by the  lesser of (1) the price  equal to the
average of the closing  price of the Common  Stock for the 60 trading days prior
to the date of repayment  and (2) the  conversion  price for  conversion  at the
option of the holder of the conversion right. On September 2, 2003, EIS acquired
an  aggregate  of  5,203,243  shares of the  Common  Stock as  repayment  of all
principal  of and accrued  interest  on the  Convertible  Note at the  following
prices:  (a) 3,577,879 shares at a price of $2.09, (b) 487,248 shares at a price
of $1.95,  (c) 101,439 shares at a price of $1.88, (d) 107,044 shares at a price
of $1.19,  (e) 124,630 shares at a price of $0.96, (f) 217,549 shares at a price
of $0.83,  (g) 87,922 shares at a price of $0.65,  (h) 221,757 shares at a price
of $0.57 and (i) 277,775 shares at a price of $0.49.

Item 4.  Purpose of Transaction.

     Item 4 of the Schedule  13D is hereby  amended and restated in its entirety
as follows:

     EIS acquired the above-referenced  securities for investment  purposes,  as
interest  on  the  Convertible   Promissory  Note  or  in  connection  with  the
Termination Agreement.



                                  Page 5 of 12


     The Issuer has granted to EIS  certain  demand and  piggyback  registration
rights for the shares of Common Stock held by EIS.

     EIS and the Issuer agreed in the Securities  Purchase Agreement that for so
long as EIS and/or its affiliates or subsidiaries  collectively  own at least 5%
of the shares of Common Stock and/or common stock equivalents of the Issuer on a
fully  diluted  basis,  EIS would have the right to nominate  one  director  for
election to the Issuer's  Board of Directors  who was required to be a member of
senior  management  of Elan, or otherwise  acceptable  to the Issuer.  EIS never
nominated  a  director  and its right to  nominate  a  director  was  terminated
pursuant to the Termination Agreement.

     EIS  intends to sell  shares of the Common  Stock from time to time in open
market  transactions,  subject to market conditions and the volume  restrictions
described in Item 6. EIS expects to evaluate its  investment in the Issuer on an
ongoing basis and EIS may determine to change its investment intent with respect
to the Issuer at any time. In  determining  from time to time whether to sell or
to retain its holdings of remaining securities of the Issuer, EIS will take into
consideration  such factors as it deems relevant,  including the market price of
the Common Stock,  conditions in the securities markets generally,  the Issuer's
financial  condition,  business and prospects and general  economic  conditions.
Subject  to the  volume  restrictions  described  in  Section  6  below  and any
restrictions imposed under applicable securities laws, EIS reserves the right to
dispose  of all or a portion  of its  holdings  of  securities  of the Issuer in
public  or  private  transactions  and/or  to enter  into  privately  negotiated
derivative  transactions with  institutional  counterparties to hedge the market
risk of some or all of its position in the  securities  of the Issuer.  Any such
transaction may be effected at any time or from time to time.

     Except as set forth above in Item 3 or this Item 4 above,  neither Elan nor
EIS has any plan or proposal which relates to or would result in:

          (a) The  acquisition  by any person of  additional  securities  of the
     Issuer, or the disposition of securities of the Issuer;

          (b)  An  extraordinary   corporate   transaction  such  as  a  merger,
     reorganization   or  liquidation   involving  the  Issuer  or  any  of  its
     subsidiaries;

          (c) A sale or transfer of a material amount of assets of the Issuer or
     any of its subsidiaries;

          (d) Any change in the present  Board of Directors or management of the
     Issuer,  including  any plans or  proposals to change the number of term of
     Directors or to fill any existing vacancies on the Board;

          (e) Any  material  change in the  present  capitalization  or dividend
     policy of the Issuer;

          (f) Any other  material  change in the Issuer's  business or corporate
     structure;

          (g)  Changes  in  the  Issuer's  charter,   by-laws,   or  instruments
     corresponding  thereto or other actions which may impede the acquisition of
     control of the Issuer by any person;

          (h) Causing the Common Stock to cease to be authorized to be traded on
     the Nasdaq National Market;

          (i) To have the Common Stock  terminated from  registration  under the
     Securities Act of 1933; or

          (j) Any action similar to any of those enumerated above.



                                  Page 6 of 12


     The foregoing  descriptions  of the Securities  Purchase  Agreement and the
Termination  Agreement do not purport to be complete and are  qualified in their
entirety  by  reference  to the  full  text  thereof.  The  Securities  Purchase
Agreement and the Termination Agreement are incorporated by reference herein.

Item 5.  Interest in Securities of Issuer.

     Item 5 of the Schedule  13D is hereby  amended and restated in its entirety
as follows:

          (a) As of April 6, 2004,  Elan  (indirectly)  and EIS (directly)  each
     beneficially own 12,064,882 shares of Common Stock,  representing  14.8% of
     the  outstanding  shares of Common  Stock  (based on  81,574,183  shares of
     Common  Stock  outstanding,  including  77,244,183  shares of Common  Stock
     outstanding on March 1, 2004, as reported in the Issuer's  definitive proxy
     statement  on  Schedule  14A filed with the SEC on 3/24/04  plus  4,330,000
     shares issued upon conversion of the Series B Preferred Stock).

          (b) As of  April  6,  2004,  Elan  and  EIS  have  shared  voting  and
     dispositive power over 12,064,882 shares of Common Stock and no sole voting
     or dispositive power over shares of Common Stock.

          (c) On March 31, 2004, EIS converted the Series B Preferred Stock plus
     all accrued and unpaid dividends  thereon and received  4,330,000 shares of
     Common  Stock,  having  waived  the right to receive  additional  shares of
     Common Stock upon conversion.

          (d) Not applicable.

          (e) Not applicable.

Item 6. Contracts, Arrangements,  Understanding or Relationships with Respect to
        Securities of the Issuer.

     Item 6 of the Schedule  13D is hereby  amended and restated in its entirety
as follows:

     The Securities  Purchase  Agreement  provided that,  except with respect to
certain permitted transfers or assignments, EIS was restricted from transferring
or assigning the Series B Preferred  Stock, the Common Stock, or the Convertible
Note, or any interest therein,  without the prior written consent of the Issuer.
In the  Termination  Agreement,  the parties  terminated such  restrictions  and
agreed that EIS will be prohibited  from  transferring  securities of the Issuer
unless it complies  with volume  restrictions  equivalent to those found in Rule
144(e)(1)  under the Securities Act of 1933,  except that, from November 1, 2004
until December 31, 2004, EIS shall be permitted to sell a number of shares equal
to 150% of the number of shares that would be permitted  to be sold  pursuant to
Rule  144(e)(1)  and,  after December 31, 2004, EIS shall be permitted to sell a
number of shares  equal to 175% of the number of shares that would be  permitted
to be sold pursuant to Rule  144(e)(1);  provided,  further,  that some sales of
blocks ("cross  transactions"  posted by EIS's  principal  broker) of 100,000 or
more  shares of Common  Stock shall not be subject to such  above-agreed  volume
restrictions.

     The  volume  limitations  set  forth  above do not  apply to  transfers  of
securities to EIS's  affiliates or  subsidiaries,  provided the above referenced
volume limitations shall continue to apply to such shares.

     Until  such time as the  holdings  of Common  Stock by EIS,  including  its
affiliates  and  subsidiaries,  is less  than 5% of JVP's  total  common  shares
outstanding,  EIS shall report to JVP within 15 days of the end of each calendar
quarter,  its then current  holdings of JPV Common  Stock and cross  transaction
block trades during the quarter that are excluded from the volume limitations.



                                  Page 7 of 12


     The  Parties   recognize  that  such  securities  also  remain  subject  to
restrictions imposed under applicable securities laws.

     Except  as  described  in  Items 3 and 4,  there  are no  other  contracts,
arrangements,  understandings  or relationships  described in Item 6 of Schedule
13D.

Item 7.  Material to Be Filed as Exhibits.

     Item 7 of the Schedule  13D is hereby  amended and restated in its entirety
as follows:

          1. Joint  Filing  Agreement  dated  November 5, 2003  between Elan and
     EIS.(1)

          2. Securities Purchase Agreement, dated as of July 21, 1999.(2)

          3. Convertible Promissory Note, dated July 21, 1999.(2)

          4. Articles of Amendment of the Issuer  incorporating  the Designation
     of Rights and  Preferences of Series B Preferred Stock filed with the State
     of Washington on July 21, 1999.(2)

          5. Registration Rights Agreement, dated as of July 21, 1999.(2)

          6. Termination Agreement, dated as of March 31, 2004.(3)



----------

1    Filed  as an  Exhibit  to the  Schedule  13D/A1  filed  by Elan  and EIS on
     November 5, 2003.

2    Incorporated  Incorporated  by reference to the Issuer's  Current Report on
     Form 8-K dated August 4, 1999 (Commission File No. 000-23930).

3    Incorporated by reference to the Issuer's  Current Report on Form 8-K dated
     April 6, 2004 (Commission File No.  000-23930);  confidential  treatment of
     portions of such Agreement has been requested.



                                  Page 8 of 12




                                    SIGNATURE

     After reasonable  inquiry and to the best of its knowledge and belief,  the
undersigned  certifies that the information set forth in this statement is true,
complete and correct.

Dated:  April 6, 2004
                                ELAN CORPORATION, PLC


                                By:  /s/  William F. Daniel
                                     -------------------------------------
                                     Name:    William F. Daniel
                                     Title:  Executive Vice President
                                             and Company Secretary
Dated:  April 6, 2004
                                ELAN INTERNATIONAL SERVICES, LTD.


                                By:  /s/  Debra Moore Buryj
                                     -------------------------------------
                                     Name:    Debra Moore Buryj
                                     Title:   Vice President




                                  Page 9 of 12




                                   SCHEDULE A

     The (a) name, (b) business  address,  (c) present  principal  occupation or
employment and the name,  principal  business and address of any  corporation or
other  organization in which such employment is conducted and (d) citizenship of
each executive officer and director (other than Messrs. Armen, Boushel, Crowley,
Gillespie,  Groom, McGowan, McIntyre,  McLaughlin,  Selkoe, Thornburgh and Tully
and Ms. Gray) of Elan are set forth below:

          1. (a) G. Kelly Martin, (b) 345 Park Avenue, New York, New York 10154,
     (c) President and Chief Executive Officer, and (d) United States.

          2. (a) Shane  Cooke,  (b)  Lincoln  House,  Lincoln  Place,  Dublin 2,
     Ireland,  (c) Executive Vice President and Chief Financial Officer, and (d)
     Ireland.

          3. (a) William F. Daniel (b) Lincoln House,  Lincoln Place,  Dublin 2,
     Ireland,  (c)  Executive  Vice  President  and Company  Secretary,  and (d)
     Ireland.

          4. (a) Jean Duvall,  (b) 800 Gateway Blvd.,  South San  Francisco,  CA
     94080,  (c) Executive  Vice President and General  Counsel,  and (d) United
     States.

     The (a) name, (b) business  address,  (c) present  principal  occupation or
employment and the name,  principal  business and address of any  corporation or
other  organization in which such employment is conducted and (d) citizenship of
each  director  (other  than  Messrs.  Martin and  Daniel) of Elan are set forth
below:

          1. (a) Garo A. Armen,  Ph.D.,  (b) 630 Fifth Avenue,  Suite 2167,  New
     York, New York 10111, (c) Chairman of the Board and Chief Executive Officer
     of Antigenics, Inc., and (d) United States.

          2. (a)  Brendan  E.  Boushel,  (b) 9 Upper  Mount  Street,  Dublin  2,
     Ireland, (c) Retired, and (d) Ireland.

          3. (a) Laurence G. Crowley,  (b) c/o Elan  Corporation,  plc,  Lincoln
     House,  Lincoln Place,  Dublin 2, Ireland,  (c) Governor (Chairman) Bank of
     Ireland, and (d) Ireland.

          4. (a)  Alan R.  Gillespie,  Ph.D.,  (b) c/o  Elan  Corporation,  plc,
     Lincoln House, Lincoln Place, Dublin 2, Ireland, (c) Chairman,  Ulster Bank
     Limited, and (d) United Kingdom.

          5. (a) Ann Maynard Gray, (b) c/o Elan Corporation, plc, Lincoln House,
     Lincoln Place, Dublin 2, Ireland, (c) Retired, and (d) United Kingdom.

          6. (a) John  Groom,  (b) c/o Elan  Corporation,  plc,  Lincoln  House,
     Lincoln Place, Dublin 2, Ireland, (c) Retired, and (d) United Kingdom.

          7. (a) Kieran McGowan,  (b) c/o Elan Corporation,  plc, Lincoln House,
     Lincoln Place Dublin 2, Ireland, (c) Retired, and (d) Ireland.

          8. (a) Kevin McIntyre,  M.D., (b) c/o Elan  Corporation,  plc, Lincoln
     House,  Lincoln Place, Dublin 2, Ireland,  (c) Associate Clinical Professor
     of Medicine at Harvard Medical School, and (d) United States.

          9. (a) Kyran McLaughlin,  (b) Davy House, 49 Dawson Street,  Dublin 2,
     Ireland, (c) Head of Equities and Corporate Finance, Davy Stockbrokers, and
     (d) Ireland.



                                 Page 10 of 12


          10. (a) Dennis J. Selkoe, M.D., (b) c/o Elan Corporation, plc, Lincoln
     House,  Lincoln  Place,  Dublin 2, Ireland,  (c) Professor of Neurology and
     Neuroscience at Harvard Medical School, and (d) United States.

          11. (a) Richard L. Thornburgh, (b) c/o Elan Corporation,  plc, Lincoln
     House,  Lincoln  Place,  Dublin 2, Ireland,  (c) Counsel to the law firm of
     Kirkpatrick & Lockhart LLP, and (d) United States.

          12. (a) Daniel P. Tully, (b) c/o Elan Corporation, plc, Lincoln House,
     Lincoln Place, Dublin 2, Ireland, (c) Retired, and (d) United States.

     The (a) name, (b) business  address,  (c) present  principal  occupation or
employment and the name,  principal  business and address of any  corporation or
other  organization in which such employment is conducted and (d) citizenship of
each executive officer and director of EIS are set forth below:

          1. Kevin Insley,  (b) c/o 102 St. James Court,  Flatts,  Smiths FL 04,
     Bermuda,  (c) Director,  President  and Chief  Financial  Officer,  and (d)
     United Kingdom.

          2. (a) Debra Moore Buryj, (b) c/o 102 St. James Court, Flatts,  Smiths
     FL 04, , Bermuda, (c) Director and Vice President and, (d) United States.

          3. (a) David J.  Doyle,  (b) c/o  Clarendon  House,  2 Church  Street,
     Hamilton HM 11, Bermuda,  (c) Director of EIS, and principal  occupation is
     lawyer,  law firm of Conyers,  Dill & Pearman,  Clarendon  House,  2 Church
     Street, Hamilton HM 11, Bermuda, and (d) Bermuda.




                                 Page 11 of 12




                                  EXHIBIT INDEX

1.   Joint Filing Agreement dated November 5, 2003 between Elan and EIS.(4)

2.   Securities Purchase Agreement, dated as of July 21, 1999.(5)

3.   Convertible Promissory Note, dated July 21, 1999.(2)

4.   Articles of Amendment of the Issuer incorporating the Designation of Rights
     and Preferences of Series B Preferred Stock filed with the State of
     Washington on July, 21, 1999.(2)

5.   Registration Rights Agreement, dated as of July 21, 1999.(2)

6.   Termination Agreement, dated as of March 31, 2004.(3)



----------


1        Filed as an Exhibit to the Schedule 13D/A1 filed by Elan
         and EIS on November 5, 2003.

2        Incorporated Incorporated by reference to the Issuer's
         Current Report on Form 8-K dated August 4, 1999
         (Commission File No. 000-23930).

3        Incorporated by reference to the Issuer's Current Report
         on Form 8-K dated April 6, 2004 (Commission File No.
         000-23930); confidential treatment of portions of such
         Agreement has been requested.




                                 Page 12 of 12