Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Vivo Ventures Fund VI, L.P.
  2. Issuer Name and Ticker or Trading Symbol
AVANIR PHARMACEUTICALS, INC. [AVNR]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
575 HIGH STREET, SUITE 201
3. Date of Earliest Transaction (Month/Day/Year)
08/11/2009
(Street)

PALO ALTO, CA 94301
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 08/11/2009   S   49,800 D $ 4.05 (1) 8,282,003 I See Note (3) (4)
Common Stock 08/11/2009   S   232,450 D $ 3.3725 (2) 8,049,553 I See Note (3) (4)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Vivo Ventures Fund VI, L.P.
575 HIGH STREET, SUITE 201
PALO ALTO, CA 94301
    X    
Vivo Ventures VI, LLC
575 HIGH STREET, SUITE 201
PALO ALTO, CA 94301
    X    

Signatures

 /s/ Frank Kung, Ph.D., as Managing Member of Vivo Ventures VI, LLC, general partner of Vivo Ventures Fund VI, L.P.   08/13/2009
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Constitutes the weighted average sales price for multiple transactions reported on this line having prices per share ranging from $4.00 to $4.08. The Reporting Persons will provide upon request by the Commission staff, Avanir Pharmaceuticals, Inc. ("Issuer") or security holder of the Issuer, full information regarding each separate transaction.
(2) Constitutes the weighted average sales price for multiple transactions reported on this line having prices per share ranging from $3.00 to $3.99. The Reporting Persons will provide upon request by the Commission staff, the Issuer or security holder of the Issuer, full information regarding each separate transaction.
(3) Of the shares reported in the transactions: the total of 280,197 were disposed of by Vivo Ventures Fund VI, L.P., a Delaware limited partnership ("Vivo Fund") and 282,250 were disposed of by Vivo Ventures VI, LLC, a California limited liability company ("Vivo Ventures"). Vivo Ventures is the general partner of both Vivo Fund and Vivo Ventures VI Affiliates Fund L.P., a Delaware limited partnership ("Affiliates Fund"); Vivo Ventures may be deemed to have indirect beneficial ownership of shares of the Issuer directly owned by Vivo Fund and Affiliates Fund. Of the total shares reported: 7,994,998 are owned directly by Vivo Fund and 54,555 are owned directly by Affiliates Fund. Vivo Fund and Affiliates Fund also hold warrants to acquire an additional 3,037,854 and 22,255 shares of common stock.
(4) The warrants contain a limitation on exercise that prevent the Reporting Persons from exercising any warrants in the next 60 days if, after giving effect to the exercise, the Reporting Persons would in the aggregate beneficially own more than 9.99% of the outstanding shares of common stock. The Reporting Persons disclaim beneficial ownership of such securities except to the extent the Reporting Person's pecuniary interest in such securities.

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