Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Expires: January 31, 2005
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
Intersouth Associates VI, LLC
  2. Issuer Name and Ticker or Trading Symbol
ALIMERA SCIENCES INC [ALIM]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) __X__ Other (specify below)
May be part of 13(d) group
(Last)
(First)
(Middle)
C/O INTERSOUTH PARTNERS, 406 BLACKWELL STREET, SUITE 200
3. Date of Earliest Transaction (Month/Day/Year)
04/27/2010
(Street)

DURHAM, NC 27701-3984
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 04/27/2010   C   824,679 A (1) 824,679 I See footnote (2)
Common Stock 04/27/2010   C   560,934 A (3) 1,385,613 I See footnote (2)
Common Stock 04/27/2010   C   576,859 A (3) 1,962,472 I See footnote (2)
Common Stock 04/27/2010   P   90,909 A $ 11 2,053,381 I See footnote (2)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series A Preferred Stock (1) 04/27/2010   C     824,679 (4)   (5)   (6) Common Stock 824,679 (1) 0 I See footnote (2)
Series B Preferred Stock (3) 04/27/2010   C     560,934 (4)   (5)   (6) Common Stock 560,934 (3) 0 I See footnote (2)
Series C Preferred Stock (3) 04/27/2010   C     576,859 (4)   (5)   (6) Common Stock 576,859 (3) 0 I See footnote (2)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Intersouth Associates VI, LLC
C/O INTERSOUTH PARTNERS
406 BLACKWELL STREET, SUITE 200
DURHAM, NC 27701-3984
    X   May be part of 13(d) group
Mumma Mitch
C/O INTERSOUTH PARTNERS
406 BLACKWELL STREET, SUITE 200
DURHAM, NC 27701-3984
    X   May be part of 13(d) group
Dougherty Dennis
C/O INTERSOUTH PARTNERS
406 BLACKWELL STREET, SUITE 200
DURHAM, NC 27701-3984
    X   May be part of 13(d) group
INTERSOUTH PARTNERS VI LP
C/O INTERSOUTH PARTNERS
406 BLACKWELL STREET, SUITE 200
DURHAM, NC 27701-3984
    X   May be part of 13(d) group

Signatures

 /s/ Mitch Mumma   04/29/2010
**Signature of Reporting Person Date

 /s/ Dennis Dougherty   04/29/2010
**Signature of Reporting Person Date

 /s/ Mitch Mumma, Intersouth Partners VI, L.P., By: Intersouth Associates VI, LLC, Its General Partner, By: Mitch Mumma, Title: Member Manager   04/29/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) 781,092 shares of Series A Preferred Stock automatically converted into 824,679 shares of common stock immediately prior to the closing of the Issuer's initial public offering, for no additional consideration.
(2) The reportable securities are owned directly by Intersouth Partners VI, L.P. ("IP VI"). Intersouth Associates VI, LLC ("IA VI, LLC") is the general partner of IP VI. IA VI, LLC disclaims beneficial ownership of these securities and this report shall not be deemed an admission that IA VI, LLC is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. Each of Mitch Mumma ("Mumma") and Dennis Dougherty ("Dougherty") are the member managers of IA VI, LLC. Each of Mumma and Dougherty disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their pecuniary interest therein.
(3) Each outstanding share of preferred stock automatically converted into 1 share of common stock immediately prior to the closing of the Issuer's initial public offering, for no additional consideration.
(4) Reflects a 3.4-for-1 reverse stock split, effective as of immediately prior to the effectiveness of the Registration Statement on Form S-1 (File No. 333-162782).
(5) Immediately.
(6) Not applicable.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.