Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Expires: January 31, 2005
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
ACP IV, L.P.
  2. Issuer Name and Ticker or Trading Symbol
ACELRX PHARMACEUTICALS INC [ACRX]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
ONE EMBARCADERO CENTER, SUITE 3700, 
3. Date of Earliest Transaction (Month/Day/Year)
02/16/2011
(Street)

SAN FRANCISCO, CA 94111
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 02/16/2011   C   682,904 A (1) 682,904 D (2)  
Common Stock 02/16/2011   C   328,064 A (3) 1,010,968 D (2)  
Common Stock 02/16/2011   C   810,129 A (4) 1,821,097 D (2)  
Common Stock 02/16/2011   C   279,097 A (5) 2,100,194 D (2)  
Common Stock 02/16/2011   C   14,713 A (4) 2,114,897 D (2)  
Common Stock 02/16/2011   P   680,000 A $ 5 2,794,907 D (2)  

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series A Convertible Prefered Stock (1) 02/16/2011   C     500,000   (6)   (7) Common Stock 682,904 (1) 0 D (2)  
Series B Convertible Preferred Stock (3) 02/16/2011   C     218,750   (6)   (7) Common Stock 328,064 (3) 0 D (2)  
Series C Convertible Preferred Stock (4) 02/16/2011   C     810,129   (6)   (7) Common Stock 810,129 (4) 0 D (2)  
Convertible Promissory Notes (8) 02/16/2011   J     $ 644,556   (9)   (9) Common Stock 163,914 (9) $ 1,097,487 D (2)  
Warrant to Purchase Series C Convertible Preferred Stock (8) 02/16/2011   J     40,865   (10)   (11) Series C Preferred 40,865 (10) 69,588 D (2)  
Convertible Promissory Notes (5) 02/16/2011   C     $ 1,097,487   (5)   (5) Common Stock 279,097 (5) 0 D (2)  
Warrant to Purchase Series C Convertible Preferred Stock (10) 02/16/2011   X     69,588   (10)   (12) Series C Preferred 69,588 (10) 0 D (2)  
Series C Convertible Preferred Stock (4) 02/16/2011   X   69,588 (13)     (6)   (7) Common Stock 69,588 (4) 0 D (2)  
Series C Convertible Preferred Stock (4) 02/16/2011   S     54,875 (13)   (6)   (7) Common Stock 54,875 $ 5 14,713 D (2)  
Series C Convertible Preferred Stock (4) 02/16/2011   C     14,713   (6)   (7) Common Stock 14,713 (4) 0 D (2)  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
ACP IV, L.P.
ONE EMBARCADERO CENTER, SUITE 3700
SAN FRANCISCO, CA 94111
    X    
NOHRA GUY P
ONE EMBARCADERO CENTER, SUITE 3700
SAN FRANCISCO, CA 94111
  X   X    
JANNEY DANIEL
ONE EMBARCADERO CENTER, SUITE 3700
SAN FRANCISCO, CA 94111
    X    
DELEAGE JEAN
ONE EMBARCADERO CENTER
37TH FLOOR
SAN FRANCISCO, CA 94111
    X    
Mack David Henry
ONE EMBARCADERO CENTER, SUITE 3700
SAN FRANCISCO, CA 94111
    X    
ACMP IV LLC
ONE EMBARCADERO CENTER, SUITE 3700
SAN FRANCISCO, CA 94111
    X    

Signatures

 /s/ by ACMP IV, LLC, by Guy Nohra, Director   02/18/2011
**Signature of Reporting Person Date

 /s/ Guy Nohra   02/18/2011
**Signature of Reporting Person Date

 /s/ Daniel Janney   02/18/2011
**Signature of Reporting Person Date

 /s/ Jean Deleage   02/18/2011
**Signature of Reporting Person Date

 /s/ David Mack   02/18/2011
**Signature of Reporting Person Date

 /s/ by Guy Nohra, Director   02/18/2011
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The shares reflect the automatic conversion of 500,000 shares of the Issuer's Series A Preferred Stock for 682,904 shares of the Issuer's Common Stock immediately prior to the closing of the Issuer's initial public offering.
(2) ACMP IV, LLC ("ACMPIV") is the general partner of ACP IV, L.P. ("ACPIV") Jean Deleage, Daniel Janney, David Mack, and Guy Nohra are directors of ACMPIV and may be deemed to share voting and dispositive power with respect to all securities of the Issuer held by ACPIV. Guy Nohra is also a director of the Issuer. Mr. Deleage, Mr. Janney, Mr. Mack, and Mr. Nohra disclaim beneficial ownership of such securities except to the extent of his proportionate pecuniary interest therein.
(3) The shares reflect the automatic conversion of 218,750 shares of Series B Preferred Stock for 328,064 shares of Common Stock immediately prior to the closing of the Issuer's initial public offering.
(4) The shares reflect the automatic conversion of shares of the Issuer's Series C Preferred Stock into Common Stock on a one-to-one basis upon the closing of the Issuer's initial public offering.
(5) Notes and accrued interest in the aggregate of $1,116,388.59 converted automatically upon the closing of the Issuer's initial public offering into shares of Common Stock at a conversion price of $4.00, which is 80% of the per share price of the Common Stock sold in the Issuer's initial public offering.
(6) Immediately convertible into shares of the Issuer's Common Stock.
(7) These shares have no expiration date.
(8) Pursuant to Note and Warrant Transfer Agreement dated February 16, 2011, ACP IV, L.P. transferred (i)a convertible promissory note in the amount of $655,656.79 including accrued interest and (ii)an associated warrant to purchase preferred stock on the Issuer, exercisable into 40,865 shares of Series C Preferred Stock.
(9) Principal amount plus interest converts automatically upon the closing of the Issuer's initial public offering into shares of Common Stock at a conversion price of $4.00, which is 80% of the per share price of the Common Stock sold in the Issuer's initial public offering.
(10) The exercise price is $3.9428 per share and immediately exercisable prior to and contingent upon the closing of the Issuer's initial public offering.
(11) Pursuant to its terms, warrant would terminate at the closing of the Issuer's intial public offering. In the event the Issuer's public offering did not occur, the warrant would have terminated on September 14, 2017, unless earlier terminated in accordance with its terms, in a liquidation or change of control transaction.
(12) Pursuant to its terms, warrant shall terminate at the closing of the Issuer's intial public offering. Holder has elected to net exercise the warrants contingent upon and effective immediately prior to the closing of the Issuer's initial public offering of common stock.
(13) These shares reflect the net exercise of the Series C warrant pursuant to the terms fo the warrant into 14,713 shares of the Issuer's Series C Preferred Stock.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.