Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Lee Patrick
  2. Issuer Name and Ticker or Trading Symbol
ALIMERA SCIENCES INC [ALIM]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
470 UNIVERSITY AVENUE
3. Date of Earliest Transaction (Month/Day/Year)
09/29/2014
(Street)

PALO ALTO, CA 94301
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 09/29/2014 10/02/2014 S   240,662 (1) (2) (3) D $ 5.466 3,394,322 I See Footnotes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10)
Common Stock 09/30/2014 10/03/2014 S   348,962 D $ 5.4162 3,045,360 I See Footnotes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10)
Common Stock 09/30/2014 10/03/2014 S   4,100 D $ 5.4288 3,041,260 I See Footnotes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10)
Common Stock 09/30/2014 10/03/2014 S   1,000 D $ 5.5 3,040,260 I See Footnotes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10)
Common Stock 10/01/2014 10/06/2014 S   26,467 D $ 5.1641 3,013,793 I See Footnotes (1) (2) (3) (4) (5) (6) (7) (8) (9) (10)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Lee Patrick
470 UNIVERSITY AVENUE
PALO ALTO, CA 94301
    X    

Signatures

 /s/ Patrick Lee   10/01/2014
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Palo Alto Investors, LLC ("PAI LLC") is the General Partner of Micro Cap Partners, L.P. ("Micro Cap"), Palo Alto Healthcare Master Fund, L.P. ("Healthcare Master"), Palo Alto Healthcare Master Fund II, L.P. ("Healthcare Master II"), Palo Alto Healthcare Fund L.P. ("Healthcare LP"), Palo Alto Healthcare Fund II L.P. ("Healthcare II LP") and Palo Alto Micro Cap Liquidating Fund, L.P. ("Liquidating Fund").
(2) Patrick Lee, M.D. is the co-managing member of PAI LLC.
(3) Dr. Lee may be deemed to beneficially own the Common Stock, Series A Convertible Preferred Stock and Warrants owned directly by Micro Cap, Healthcare Master, Healthcare Master II and Liquidating Fund, and beneficially owned indirectly by Healthcare LP and Healthcare II LP. Dr Lee disclaims beneficial ownership of the reported securities except to the extent of his pecuniary interest therein. Reported holdings include the following held directly by Micro Cap, Healthcare Master, Healthcare Master II and Liquidating Fund: Micro Cap - 129,000 shares of Common Stock, 323,308 shares of Common Stock acquirable immediately upon conversion of 21,500 shares of Series A Convertible Preferred Stock, and and exercisable Warrant for 6,450 shares of Series A Convertible Preferred Stock, which could be immediately converted into 96,992 shares of Common Stock; [To be continued in Footnote (4)]
(4) Healthcare Master -- 1,216,563 shares of Common Stock, 3,476,691 shares of Common Stock acquirable immediately upon conversion of 231,200 shares of the Series A Convertible Preferred Stock, and an exercisable Warrant for 69,360 shares of Series A Convertible Preferred Stock, which could be immediately converted into 1,043,007 shares of Common Stock; Healthcare Master II -- 1,668,230 shares of Common Stock, 5,222,556 shares of Common Stock acquirable immediately upon conversion of 347,300 shares of the Series A Convertible Preferred Stock, and an exercisable Warrant for 104,190 shares of Series A Convertible Preferred Stock, which could be immediately converted into 1,566,776 shares of Common Stock. [To be continued in Footnote (5)]
(5) Healthcare LP owns 87.52% of the limited partnership interests in Healthcare Master. Healthcare II LP owns 72.80% of the limited partnership interests in Healthcare Master II.
(6) The conversion price of Series A Convertible Preferred Stock into common stock is $2.66.
(7) The amount or number of shares reported herein reflects the amount or number of shares of Series A Convertible Preferred Stock that may be acquired at an exercise price of $44 per share. Additionally, at the election of the holder, the Warrants provide for the option to purchase shares of Common Stock at an exercise price of $44 divided by the number of shares of Common Stock then issued or issuable upon conversion of one share of Series A Convertible Preferred Stock. [To be continued in Footnote (8)]
(8) If the holder elects to exercise the Warrant to purchase Common Stock, it would be entitled to purchase up to the number of shares of Common Stock as would be issuable upon conversion of the shares of Series A Convertible Preferred Stock subject to the Warrant. Accordingly, whether the holder elects to exercise its option to purchase Series A Convertible Preferred Stock or Common Stock pursuant to the Warrant, neither the number of shares of Common Stock ultimately acquirable nor the percentage ownership in Alimera Sciences, Inc. would be impacted.
(9) Series A Convertible Preferred Stock does not have an expiration date.
(10) Warrant to purchase Series A Convertible Preferred Stock or Common Stock (right to buy) expires October, 2017.

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