CUSIP
No. 05348P401
|
|
1
|
NAMES OF
REPORTING PERSON
S.S.
OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Samuel
D. Isaly
|
|||
2
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a)
o
(b)
o
|
|
||
3
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SEC
USE ONLY
|
|||
4
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
United
States
|
|||
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY
EACH
REPORTING
PERSON
WITH
|
5
|
SOLE
VOTING POWER
0
|
||
6
|
SHARED
VOTING POWER
5,665,176
|
|||
7
|
SOLE
DISPOSITIVE POWER
0
|
|||
8
|
SHARED
DISPOSITIVE POWER
5,665,176
|
|||
9
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
5,665,176
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|||
10
|
CHECK
IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See
Instructions)
|
o
|
||
11
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
7.24%
|
|||
12
|
TYPE
OF REPORTING PERSON (See Instructions)
IN
|
CUSIP
No. 05348P401
|
|
1
|
NAMES OF
REPORTING PERSON
S.S.
OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
OrbiMed
Advisors LLC
|
|||
2
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a)
o
(b)
o
|
|
||
3
|
SEC
USE ONLY
|
|||
4
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
Delaware
|
|||
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY
EACH
REPORTING
PERSON
WITH
|
5
|
SOLE
VOTING POWER
0
|
||
6
|
SHARED
VOTING POWER
193,188
|
|||
7
|
SOLE
DISPOSITIVE POWER
0
|
|||
8
|
SHARED
DISPOSITIVE POWER
193,188
|
|||
9
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
193,188
|
|||
10
|
CHECK
IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See
Instructions)
|
o
|
||
11
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
0.25%
|
|||
12
|
TYPE
OF REPORTING PERSON (See Instructions)
IA
|
CUSIP
No. 05348P401
|
|
1
|
NAMES OF
REPORTING PERSON
S.S.
OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
OrbiMed
Capital GP II LLC
|
|||
2
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a)
o
(b)
o
|
|
||
3
|
SEC
USE ONLY
|
|||
4
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
Delaware
|
|||
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY
EACH
REPORTING
PERSON
WITH
|
5
|
SOLE
VOTING POWER
0
|
||
6
|
SHARED
VOTING POWER
5,471,988
|
|||
7
|
SOLE
DISPOSITIVE POWER
0
|
|||
8
|
SHARED
DISPOSITIVE POWER
5,471,988
|
|||
9
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
5,471,988
|
|||
10
|
CHECK
IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See
Instructions)
|
o
|
||
11
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
7.00%
|
|||
12
|
TYPE
OF REPORTING PERSON (See Instructions)
OO
|
Item
1(a).
|
Name
of Issuer:
|
Item
1(b).
|
Address
of Issuer's Principal Executive
Offices:
|
Item
2(a).
|
Name
of Person Filing:
|
Item
2(b).
|
Address
of Principal Business Office or, if none,
Residence:
|
|
767
Third Avenue, 30th
Floor
|
|
New
York, New York 10017
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Item
2(c).
|
Citizenship:
|
Item
2(d).
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Title
of Class of Securities:
|
Item
2(e).
|
CUSIP
Number:
|
(a)
|
Amount
Beneficially Owned: See Item 9 of each coversheet for each
reporting person
|
|
(b)
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Percent
of Class: See Item 11 of each coversheet for each reporting
person
|
|
(c)
|
Number
of shares as to which such person
has:
|
(i)
|
sole
power to vote or to direct the vote
|
See
Item 5 of each coversheet for each reporting
person
|
(ii)
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shared
power to vote or to direct the vote
|
See
Item 6 of each coversheet for each reporting
person
|
(iii)
|
sole
power to dispose or to direct the disposition of
|
See
Item 7 of each coversheet for each reporting
person
|
(iv)
|
shared
power to dispose or to direct the disposition of
|
See
Item 8 of each coversheet for each reporting
person
|
Item 7.
|
Identification
and Classification of the Subsidiary Which Acquired the Security Being
Reported on By the Parent Holding
Company.
|
Dated: May 27, 2009 | ||||
SAMUEL D. ISALY | ||||
By: | /s/ Samuel D. Isaly | |||
Samuel D. Isaly | ||||
ORBIMED ADVISORS LLC | ||||
By: | /s/ Samuel D. Isaly | |||
Samuel D. Isaly | ||||
Managing Member | ||||
ORBIMED CAPITAL GP II LLC | ||||
By: | /s/ Samuel D. Isaly | |||
Samuel D. Isaly | ||||
Managing Member | ||||
SAMUEL D. ISALY | ||||
By: | /s/ Samuel D. Isaly | |||
Samuel D. Isaly | ||||
ORBIMED ADVISORS LLC | ||||
By: | /s/ Samuel D. Isaly | |||
Samuel D. Isaly | ||||
Managing Member | ||||
ORBIMED CAPITAL GP II LLC | ||||
By: | /s/ Samuel D. Isaly | |||
Samuel D. Isaly | ||||
Managing Member | ||||