As filed with the Securities and Exchange Commission on March 16, 2004
                                                      Registration No. 333-
--------------------------------------------------------------------------------

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                               __________________

                                    FORM S-3
                             REGISTRATION STATEMENT
                                      Under
                           THE SECURITIES ACT OF 1933
                               __________________

                                    XOMA Ltd.
             (Exact name of registrant as specified in its charter)

             Bermuda                                        52-2154066
 (State or other jurisdiction of                         (I.R.S. Employer
  incorporation or organization)                       Identification No.)

                               2910 Seventh Street
                           Berkeley, California 94710
                                 (510) 204-7200
          (Address, including ZIP code, and telephone number, including
             area code, of registrant's principal executive offices)
                               __________________

                          CHRISTOPHER J. MARGOLIN, ESQ.
                                    XOMA Ltd.
                               2910 Seventh Street
                           Berkeley, California 94710
                                 (510) 204-7292
                     (Name, address, including ZIP code, and
                        telephone number, including area
                           code, of agent for service)
                               __________________

                                    Copy to:
                           GEOFFREY E. LIEBMANN, ESQ.
                           CAHILL GORDON & REINDEL LLP
                                 80 Pine Street
                            New York, New York 10005
                                 (212) 701-3000
                               __________________

Approximate date of commencement of proposed sale to the public: From time to
time after the effective date of this Registration Statement. If the only
securities being registered on this Form are being offered pursuant to dividend
or interest reinvestment plans, please check the following box. / /

If any of the securities being registered on this Form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. /X/

If this Form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the Securities Act registration statement number of the earlier effective
registration statement for the same offering. / /

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under
the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. / /

If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. / /











                         CALCULATION OF REGISTRATION FEE

     Title of Each Class                                   Proposed             Proposed
        of Securities                  Amount               Maximum              Maximum             Amount of
            To Be                      To Be            Offering Price          Aggregate          Registration
          Registered                 Registered           per Unit(1)       Offering Price(1)           Fee
----------------------------------------------------------------------------------------------------------------

                                                                                          
Common Shares,
par value U.S.$.0005
per share...................     5,000,000 (2)(3)           $5.70             $28,500,000            $3,611



(1)  Estimated solely for the purpose of computing the registration fee pursuant
     to Rule 457(c).

(2)  Includes a like number of Preference Share Purchase Rights (the "Rights").
     Since no separate consideration is paid for the Rights, the registration
     fee is included in the fee for the Common Shares.

(3)  Pursuant to Rule 416 under the Securities Act of 1933, any additional
     Common Shares issued as a result of share subdivisions, bonus issues or
     similar transactions are deemed to be registered herewith.

The Registrant hereby amends this Registration Statement on such date or dates
as may be necessary to delay its effective date until the Registrant shall file
a further amendment which specifically states that this Registration Statement
shall thereafter become effective in accordance with Section 8(a) of the
Securities Act of 1933 or until the Registration Statement shall become
effective on such date as the Securities and Exchange Commission, acting
pursuant to said Section 8(a), may determine.

--------------------------------------------------------------------------------


                                      -2-


The information contained in this prospectus is not complete and may be changed.
This prospectus is not an offer to sell these securities and it is not
soliciting an offer to buy these securities in any state where the offer or sale
is not permitted.





--------------------------------------------------------------------------------
Prospectus                                              Subject to Completion,
                                                        dated March 16, 2004

                                    XOMA Ltd.
                             5,000,000 Common Shares
--------------------------------------------------------------------------------


o    All of the common shares covered by this prospectus are being offered by
     Millennium Pharmaceuticals, Inc., which is a party to an investment
     agreement with XOMA and has become one of our shareholders through the
     purchase of common shares under the investment agreement.

o    We have used and intend to continue to use the proceeds from our sale of
     common shares to the selling shareholders under the investment agreement
     principally for the development of products pursuant to our collaboration
     with Millennium.

o    To the extent shares are issued upon conversion of an outstanding
     convertible subordinated note, we will benefit from the resulting
     cancellation of indebtedness. The $5.0 million convertible subordinated
     note is convertible at our option into our common shares.

o    Millennium will receive all of the proceeds of its sale of such common
     shares to you.

o    Our common shares are listed on the Nasdaq National Market under the symbol
     "XOMA." The last reported sale price for the common shares on March 12,
     2004 was $5.85 per share.

-------------------------------------------------------------------------------

     This investment involves a high degree of risk. Consider carefully the risk
factors beginning on page 6 of this prospectus before you invest.

     Millennium Pharmaceuticals, Inc. is an underwriter with respect to all of
the common shares it purchases under the investment agreement with XOMA and
which are offered for sale under this prospectus.

                              ____________________

     Neither the SEC nor any state securities commission has approved these
securities or determined that this prospectus is accurate or complete. Any
representation to the contrary is a criminal offense.

                              ____________________

                The date of this prospectus is __________, 2004.






                                TABLE OF CONTENTS




                                                 Page                                                  Page


                                                                                                  
PROSPECTUS SUMMARY................................2     USE OF PROCEEDS..................................21
RISK FACTORS......................................6     SELLING SHAREHOLDER..............................22
INCORPORATION OF INFORMATION                            DESCRIPTION OF SHARE CAPITAL.....................25
   WE FILE WITH THE SEC .........................18     PLAN OF DISTRIBUTION.............................28
SPECIAL NOTE REGARDING                                  LEGAL OPINION....................................29
   FORWARD-LOOKING STATEMENTS ...................19     EXPERTS..........................................29
PRICE RANGE OF COMMON SHARES                            WHERE YOU CAN GET MORE INFORMATION...............29
  AND DIVIDEND INFORMATION ......................20














                               PROSPECTUS SUMMARY

XOMA

     We are a biopharmaceutical company that develops and manufactures
antibodies and other genetically-engineered protein products to treat
immunological and inflammatory disorders, cancer and infectious diseases. Our
current product development programs include:

o    RAPTIVA(TM) (Efalizumab) with Genentech, Inc. RAPTIVA(TM) is a humanized
     therapeutic monoclonal antibody developed to treat immune system disorders.
     RAPTIVA(TM) is the first biologic therapy designed to provide long-term
     control of chronic moderate-to-severe plaque psoriasis and can be
     self-administered by patients as a single, once-weekly subcutaneous
     injection. On October 27, 2003, the FDA approved RAPTIVA(TM) for the
     treatment of adults with chronic moderate-to-severe plaque psoriasis who
     are candidates for systemic therapy or phototherapy.

     In January of 2003, Genentech and we announced the initiation of a Phase II
     study evaluating RAPTIVA(TM) in patients with psoriatic arthritis that has
     since completed enrollment. Genentech and we continue to evaluate
     additional indications for RAPTIVA(TM).

o    MLN2222 (also known as CAB2) with Millennium Pharmaceuticals, Inc. MLN2222
     is a complement inhibitor under development to potentially reduce the
     incidence of complications in patients undergoing surgical procedures
     involving the use of cardiopulmonary bypass (CPB). In December of 2003, we
     announced the initiation of a Phase I clinical trial for the product. This
     trial is the first of two planned Phase I trials that will evaluate the
     safety, tolerability, pharmacokinetic and pharmacodynamic properties of
     MLN2222.

o    TPO mimetic antibody with Alexion Pharmaceuticals, Inc. In December of
     2003, we and Alexion formed a collaboration for the development and
     commercialization of a rationally designed human thrombopoietin (TPO)
     mimetic antibody to treat chemotherapy-induced thrombocytopenia. The
     antibody has been designed to mimic the activity of TPO, a naturally
     occurring protein responsible for platelet production, while being
     structurally distinct. Process development work and preclinical studies
     have been initiated.

o    Bactericidal Permeability Increasing Protein (BPI) derived compounds:

     XMP.629 is a topical anti-bacterial formulation of a BPI-derived peptide
     under development as a possible treatment for acne. Certain bacteria
     commonly found on human skin are associated with inflammatory lesions in
     acne patients. The emergence of strains resistant to current antibiotics
     used to treat acne has encouraged our researchers to review the properties
     of the compound for this dermatological indication. In 2003, we completed
     two Phase I clinical trials to evaluate skin irritation and
     pharmacokinetics of the compound. In January of 2004, we announced the
     initiation of Phase II clinical testing.

     NEUPREX(R) (rBPI21 ) is an injectable formulation of rBPI21, a modified
     recombinant fragment of BPI. BPI is a human host-defense protein made by
     PMN cells, a type of white blood cell that is involved in the body's
     defenses against microbial infection.


     In October of 2003, we and Children's Medical Center Dallas announced the
     initiation of an open-label, single center, dose escalation,
     investigator-sponsored, Phase I/II clinical trial of NEUPREX(R) in
     pediatric patients with congenital heart abnormalities requiring open heart
     surgery (OHS) associated with CPB. The study plans to investigate dosing,
     efficacy endpoints and safety to assess the potential for conducting
     larger, additional studies.



                                      -2-


     In July of 2003, we announced the termination of our license and supply
     agreements with Baxter Healthcare Corporation for this product. In return
     for a release from its obligations under the agreements, in January of 2004
     Baxter made a one-time payment to us of $10.0 million. Going forward,
     Baxter will have no involvement with the product.

     We have previously tested NEUPREX(R) in clinical trials for several
     infectious and inflammatory conditions including meningococcemia and are
     evaluating future options for developing the product in multiple
     indications, including seeking a pharmaceutical partner.

     BPI compounds for retinal disorders. Results of in vitro and in vivo
     studies conducted by Joslin Diabetes Center at Harvard University,
     presented in April of 2001 and published in February of 2002, show that
     compounds derived from BPI inhibit the function of multiple growth factors
     involved in blood vessel formation and angiogenesis in the retina while
     sparing key retinal cells (pericytes). These data suggest that these
     compounds may have potential for treating retinal disorders. We are
     conducting further research together with Joslin.

o    ING-1 is a Human Engineered(TM) monoclonal antibody developed by us to
     specifically target tumor cells in adenocarcinoma patients. ING-1
     antibodies bind with high affinity to the Ep-CAM antigen and recruit host
     immune cells to kill the cancer cell. The ING-1 antibody has been Human
     Engineered(TM) to reduce potential immunogenicity in patients, while
     maintaining potent activity. We have completed Phase I clinical studies of
     ING-1, testing both intravenous and subcutaneous formulations in patients
     with advanced or refractory adenocarcinomas, and the product is available
     for licensing.

     We have experienced significant losses and, as of December 31, 2003, we had
an accumulated deficit of $599.5 million. For the year ended December 31, 2003,
we had a net loss of approximately $58.7 million, or $0.78 per common share
(basic and diluted). For the year ended December 31, 2002, we had a net loss of
approximately $33.2 million, or $0.47 per common share (basic and diluted). We
expect to incur additional losses in the future, primarily due to increased
sales and marketing, expenses related to RAPTIVATM, the Alexion collaboration,
the Millennium collaboration, our XMP.629 compound and new product research
including our oncology product collaboration with Chiron Corporation.

     Based on current spending levels, revenue estimates, net proceeds received
from our recent underwritten public offering, repayment obligations of our debt
owed to Genentech for our share of RAPTIVATM marketing costs, deferral of a
portion of our development loan from Genentech, issuance of shares in repayment
of the remainder of our development loan from Genentech and financing
commitments from Millennium, we estimate we have sufficient cash resources,
together with sources of funding available to us, to meet our anticipated net
cash consumption levels through at least the end of 2005. However, to the extent
we experience continuing losses on RAPTIVATM or changes in the timing or size of
expenditures or unanticipated expenditures, or if our collaborators do not meet
their obligations to us or anticipated revenues otherwise do not materialize,
these funds may not be adequate for this period. Specifically, although the
recent FDA approval of RAPTIVATM would generally be expected to improve
operating cash flow to the extent of our share of operating profits from sales
of RAPTIVATM in the U.S., such approval also requires repayment in cash, shares
or deferred repayment of up to $40.0 million of amounts owed to Genentech
(approximately $53.3 million under both loan agreements as of December 31,
2003). In November of 2003, we announced our election to defer $40.0 million of
such repayment and to repay the remainder of the development loan using shares.
The commercialization loan is payable only in cash and approximately $3.0
million was paid in January of 2004 and approximately $10.3 million is due in
April of 2004. In addition, the receipt of regulatory approval terminated
Genentech's obligation to continue to loan us our portion of development and
commercialization expenses for RAPTIVA(TM). For a further discussion of the
risks related to our business and their effects on our cash flow and ability to
raise new funding on acceptable terms, see "Risk Factors."



                                      -3-


Material Terms of Investment Agreement

     On November 26, 2001, we entered into an investment agreement with
Millennium which committed Millennium to purchase, at our option and subject to
the conditions described in the following paragraph, up to $50.0 million worth
of our common shares over the 30 months following the effective date of the
investment agreement. Of the up to $50.0 million worth of our common shares,
$5.0 million worth (and accrued interest) may be issued at our option upon
conversion of a convertible subordinated note already issued to Millennium, the
entire principal amount of which is currently outstanding. On December 18, 2002,
Millennium purchased approximately 1.4 million of our common shares for $7.5
million to satisfy, in part, its obligation under the investment agreement. On
May 16, 2003, we and Millennium agreed to delay the maturity of the $5.0 million
convertible subordinated note until February 26, 2004 and to adjust the timing
of Millennium's obligation to purchase the remaining $37.5 million worth of our
common shares. On June 26, 2003, Millennium purchased approximately 609,000 of
our common shares for $4.0 million to satisfy, in part, its obligation under the
investment agreement. On October 10, 2003, we announced that we discontinued
development of MLNM2201 (formerly known as LDP-01), one of the two products
being developed under our collaboration with Millennium, which had the effect of
reducing Millennium's obligation to purchase our common shares under the
investment agreement by 40% from up to $33.5 million remaining to up to $20.1
million. On November 26, 2003, Millennium purchased approximately 764,000 of our
common shares for $5.4 million to satisfy, in part, its obligation under the
investment agreement. On February 24, 2004, we and Millennium agreed to delay
the maturity of the convertible debt until April 15, 2004 (or the third business
day after the date the related registration statement is declared effective, if
later) and to further adjust the timing of Millennium's obligation to purchase
the remaining $14.7 million worth of our common shares. At each of four
subsequent closings over the following 12 months, we may issue up to $3,675,000
worth of our common shares. At each closing, the precise number of shares to be
purchased by Millennium will be determined using a formula based on the average
of certain sale prices per common share as reported on the Nasdaq National
Market for a specified period of time prior to the applicable closing date
(subject to certain adjustments and limitations). The formula is intended to
reflect the current market price per common share at the time of each closing,
without any discount or premium.

     The obligations of Millennium to purchase the common shares that we wish to
sell at each closing will be subject to customary closing conditions, including
the delivery of legal opinions and certificates from our officers and updated
financial information, the continued listing of our common shares on the Nasdaq
National Market or the New York or American Stock Exchanges, the continued
effectiveness of the registration statement that includes this prospectus and
the continuation of our collaboration agreement with Millennium.

     We have agreed to register the resale of the common shares that we may sell
to Millennium at each closing and the common shares that we may issue to
Millennium upon conversion of the convertible debt. The registration statement
that includes this prospectus is intended to satisfy these registration
obligations.

     The 5,000,000 shares registered under the registration statement that
includes this prospectus would have represented 5.6% of our outstanding common
shares as of March 12, 2004, after giving effect to their issuance. Using the
formula set forth in the investment agreement as if the common shares were being
issued on March 16, 2004, the investment agreement gives us the option to
require the selling shareholders to purchase an aggregate of up to approximately
3.2 million common shares (assuming conversion of the convertible subordinated
note) for $19.7 million, in addition to the 2.8 million common shares already
purchased.

Material Terms of Convertible Subordinated Note

     In connection with the investment agreement, we issued to Millennium a $5.0
million convertible subordinated note. The principal of the convertible
subordinated note is due and payable in a single installment on April 15, 2004
(or the third business day after the date the related registration statement is
declared effective, if later).



                                      -4-


     The principal and accrued interest on the convertible subordinated note may
be converted in whole (but not in part) at our election upon maturity into our
common shares. The number of shares into which the convertible subordinated note
may be converted will be determined using a formula based on the average of
certain sale prices per common share as reported on the Nasdaq National Market
for a specified period of time prior to the conversion date (subject to certain
adjustments and limitations). The formula is intended to reflect the current
market price per common share at the time of conversion, without any discount or
premium. Using this formula as if the convertible subordinated note were being
repaid on March 16, 2004, we would be entitled to issue an aggregate of
approximately 810,000 common shares in full payment of the convertible
subordinated note.

     We have notified Millennium of our election to convert all principal and
accrued interest under the convertible note into common shares. In addition to
customary restrictions on our ability to convert, we will not be entitled to
convert any portion of the convertible subordinated note or the accrued interest
unless there is on the conversion date an effective registration statement
covering resale of all of the common shares into which the principal of the
convertible note and all accrued interest would convert. If this is not the case
at any time prior to its maturity date, then the convertible subordinated note
will remain outstanding until its maturity date. The registration statement that
includes this prospectus is intended to satisfy these registration obligations.




                                      -5-






                                  RISK FACTORS

     You should carefully consider the following factors and other information
in this prospectus before deciding to invest in our common shares. You should
also consider carefully the other information contained, or incorporated by
reference, in this prospectus. The actual results of our business could differ
materially from those described as a result of these risk factors. In such case,
the trading price of our common shares could decline, and you may lose all or
part of the money you paid to buy our common shares.

Risks Relating To Our Business

The Marketing And Sales Effort In Support Of Our Only Product To Receive
Regulatory Approval Has Only Recently Begun And May Not Be Successful.

     RAPTIVA(TM), our only product to receive regulatory approval, was approved
by the FDA on October 27, 2003 for the treatment of chronic moderate-to-severe
plaque psoriasis in adults who are candidates for systemic therapy or
phototherapy. Genentech is responsible for the marketing and sales effort in
support of this product and has only recently commenced the full intended scope
of this effort. Unless and until RAPTIVA(TM) is approved in this or other
indications outside the United States, our interest in this product in this
indication is limited to our 25% share of the operating profits or losses from
sales of the product in the United States. We currently have no active role in
this marketing and sales effort. Successful commercialization of this product is
subject to a number of risks, including Genentech's ability to implement its
marketing and sales effort and achieve sales; the strength of competition from
other products being marketed or developed to treat psoriasis; physicians' and
patients' acceptance of RAPTIVA(TM) as a treatment for psoriasis; Genentech's
ability to provide manufacturing capacity to meet demand for the product; and
pricing and reimbursement issues. Many of these risks are discussed in more
detail below.

Because All Of Our Products Are Still Being Developed, We Will Require
Substantial Funds To Continue; We Cannot Be Certain That Funds Will Be Available
And, If Not Available, We May Have To Take Actions Which Could Adversely Affect
Your Investment.

     If adequate funds are not available, we may have to dilute or otherwise
adversely affect the rights of existing shareholders, curtail or cease
operations, or file for bankruptcy protection in extreme circumstances. We have
spent, and we expect to continue to spend, substantial funds in connection with:

     o    research and development relating to our products and production
          technologies

     o    expansion of our production capabilities

     o    various human clinical trials and

     o    protection of our intellectual property.

     Based on current spending levels, revenue estimates, net proceeds received
from our recent underwritten public offering, repayment obligations of our debt
owed to Genentech for our share of RAPTIVATM marketing costs, deferral of a
portion of our development loan from Genentech, issuance of shares in repayment
of the remainder of our development loan from Genentech and financing
commitments from Millennium, we estimate we have sufficient cash resources,
together with sources of funding available to us, to meet our anticipated net
cash consumption levels through at least the end of 2005. However, to the extent
we experience continuing losses on RAPTIVATM or changes in the timing or size of
expenditures or unanticipated expenditures, or if our collaborators do not meet
their obligations to us or anticipated revenues otherwise do not materialize,
these funds may not be adequate for this period. In particular, our share of
profits or losses from RAPTIVATM may materially impact our cash resources. As a
result, we do not know whether:



                                      -6-


     o    operations will generate meaningful funds

     o    additional agreements for product development funding can be reached

     o    strategic alliances can be negotiated or

     o    adequate additional financing will be available for us to finance our
          own development on acceptable terms, if at all.

     Cash balances and operating cash flow are influenced primarily by the
timing and level of payments by our licensees and development partners, as well
as by our operating costs.

     Specifically, although the recent FDA approval of RAPTIVATM would generally
be expected to improve operating cash flow to the extent of XOMA's share of
operating profits from sales of RAPTIVATM in the U.S., such approval also
requires repayment in cash, shares or deferred repayment of up to $40.0 million
of amounts owed to Genentech (approximately $53.3 million under both loan
agreements as of December 31, 2003). In November of 2003, we announced our
election to defer $40.0 million of such repayment and to repay the remainder of
the development loan using shares. The commercialization loan is payable only in
cash and approximately $3.0 million was paid in January of 2004 and
approximately $10.3 million is due in April of 2004. In addition, the receipt of
regulatory approval terminated Genentech's obligation to continue to loan us our
portion of development and commercialization expenses for RAPTIVA(TM).

Most Of Our Therapeutic Products Have Not Received Regulatory Approval. If These
Products Do Not Receive Regulatory Approval, Neither Our Third Party
Collaborators Nor We Will Be Able To Manufacture And Market Them.

     Our products cannot be manufactured and marketed in the United States and
other countries without required regulatory approvals. Only one of our
therapeutic products has received regulatory approval. The United States
government and governments of other countries extensively regulate many aspects
of our products, including:

     o    testing,

     o    manufacturing,

     o    promotion and marketing, and

     o    exporting.

     In the United States, the FDA regulates pharmaceutical products under the
Federal Food, Drug, and Cosmetic Act and other laws, including, in the case of
biologics, the Public Health Service Act. At the present time, we believe that
most of our products will be regulated by the FDA as biologics. The review of
therapeutic biologic products has been transferred within the FDA from the
Center for Biologics Evaluation and Research to the Center for Drug Evaluation
and Research, the body that reviews drug products. Because implementation of
this plan may not be complete, we do not know when or how this change will
affect us. State regulations may also affect our proposed products.

     The FDA has substantial discretion in both the product approval process and
manufacturing facility approval process and, as a result of this discretion and
uncertainties about outcomes of testing, we cannot predict at what point, or
whether, the FDA will be satisfied with our or our collaborators' submissions or
whether the FDA will raise questions which may be material and delay or preclude
product approval or manufacturing facility approval. As we accumulate additional
clinical data, we will submit it to the FDA, which may have a material impact on
the FDA product approval process.



                                      -7-


     Our potential products will require significant additional research and
development, extensive preclinical studies and clinical trials and regulatory
approval prior to any commercial sales. This process is lengthy and expensive,
often taking a number of years. As clinical results are frequently susceptible
to varying interpretations that may delay, limit or prevent regulatory
approvals, the length of time necessary to complete clinical trials and to
submit an application for marketing approval for a final decision by a
regulatory authority varies significantly. As a result, it is uncertain whether:

     o    our future filings will be delayed,

     o    our studies will be successful,

     o    we will be able to provide necessary additional data,

     o    our future results will justify further development, or

     o    we will ultimately achieve regulatory approval for any of these
          products.

For example,

     o    in 1996, we and Genentech began testing RAPTIVATM in patients with
          moderate-to-severe plaque psoriasis. In April of 2002, we and
          Genentech announced that a pharmacokinetic study conducted on
          RAPTIVATM comparing XOMA-produced material and Genentech-produced
          material did not achieve the pre-defined statistical definition of
          comparability, and the FDA requested that another Phase III study be
          completed before the filing of a Biologics License Application for
          RAPTIVATM, delaying the filing of a Biologics Licensing Application
          with the FDA for RAPTIVATM beyond the previously-planned time frame of
          the summer of 2002. In March 2003, we announced completion of
          enrollment in a Phase II study of RAPTIVATM in patients suffering from
          rheumatoid arthritis. In May of 2003, we and Genentech announced our
          decision to terminate Phase II testing of RAPTIVATM in patients
          suffering from rheumatoid arthritis based on an evaluation by an
          independent Data Safety Monitoring Board that suggested no overall net
          clinical benefit in patients receiving the study drug. We have also
          completed enrollment in a Phase II study of RAPTIVATM as a possible
          treatment for patients with psoriatic arthritis. Although we expect to
          know preliminary results of the psoriatic arthritis trial by the end
          of the first quarter of 2004, we do not know whether or when such
          testing will demonstrate product safety and efficacy in this patient
          population or result in regulatory approval. As is our practice, more
          details regarding the clinical data will be revealed at an upcoming
          medical conference or other appropriate scientific, peer-reviewed
          forum later in 2004.

     o    in December of 1992, we began human testing of our NEUPREX(R) product,
          a genetically engineered fragment of a particular human protein, and
          licensed certain worldwide rights to Baxter in January of 2000. In
          April of 2000, members of the FDA and representatives of XOMA and
          Baxter discussed results from the Phase III trial that tested
          NEUPREX(R) in pediatric patients with a potentially deadly bacterial
          infection called meningococcemia, and senior representatives of the
          FDA indicated that the data presented were not sufficient to support
          the filing of an application for marketing approval at that time.

     Given that regulatory review is an interactive and continuous process, we
maintain a policy of limiting announcements and comments upon the specific
details of the ongoing regulatory review of our products, subject to our
obligations under the securities laws, until definitive action is taken.



                                      -8-


Because All Of Our Products Are Still Being Developed, We Have Sustained Losses
In The Past And We Expect To Sustain Losses In The Future.

     We have experienced significant losses and, as of December 31, 2003, we had
an accumulated deficit of $599.5 million.

     For the year ended December 31, 2003, we had a net loss of approximately
$58.7 million, or $0.78 per common share (basic and diluted). For the year ended
December 31, 2002, we had a net loss of approximately $33.2 million, or $0.47
per common share (basic and diluted). We expect to incur additional losses in
the future, primarily due to increased sales and marketing, expenses related to
RAPTIVATM, the Alexion collaboration, the Millennium collaboration, our XMP.629
compound and new product research including our oncology product collaboration
with Chiron Corporation.

     Our ability to achieve profitability is dependent in large part on
obtaining regulatory approval for our products and entering into agreements for
product development and commercialization, both of which are uncertain. Our
ability to fund our ongoing operations is dependent on the foregoing factors and
on our ability to secure additional funds. Because all of our products are still
being developed, we do not know whether we will ever achieve profitability or
whether cash flow from future operations will be sufficient to meet our needs.

If Third Party Collaborators Do Not Successfully Develop And Market Our
Products, We May Not Be Able To Do So On Our Own.

     Our financial resources and our marketing experience and expertise are
limited. Consequently, we depend to a large extent upon securing the financial
resources and marketing capabilities of third parties with whom we collaborate.

     o    In April of 1996, we and Genentech entered into an agreement whereby
          we agreed to co-develop Genentech's humanized monoclonal antibody
          product RAPTIVA(TM). In April of 1999, the companies amended the
          agreement. In March of 2003, the companies further amended the
          agreement. In October of 2003, RAPTIVA(TM) was approved by the FDA for
          the treatment of chronic moderate-to-severe plaque psoriasis.

     o    In November of 2001, we entered into a collaboration with Millennium
          to develop two of Millennium's products for certain vascular
          inflammation indications. In October of 2003, we announced that we had
          discontinued one of these products, MLN2201. In December of 2003, we
          announced the initiation of Phase I testing on the other product,
          MLN2222.

     o    In December of 2003, we and Alexion Pharmaceuticals, Inc. agreed to
          collaborate for the development and commercialization of an antibody
          to treat chemotherapy-induced thrombocytopenia. The TPO mimetic
          antibody was designed to mimic the activity of human thrombopoietin, a
          naturally occurring protein responsible for platelet production.

     o    In March of 2004, we and Chiron Corporation announced we had agreed to
          collaborate for the development and commercialization of antibody
          products for the treatment of cancer. Under the terms of the
          agreement, the companies will jointly research, develop, and
          commercialize multiple antibody product candidates.

     Because our collaborators are independent third parties, they may be
subject to different risks than we are and have significant discretion in
determining the efforts and resources they will apply. We do not know whether
Genentech, Millennium, Alexion or Chiron will successfully develop and market
any of the products that are or may become the subject of one of our
collaborations.



                                      -9-


     Even when we have a collaborative relationship, other circumstances may
prevent it from resulting in successful development of marketable products.

     o    In January of 2000, we licensed the worldwide rights to all
          pharmaceutical compositions containing a particular human protein for
          treatment of meningococcemia and additional potential future human
          clinical indications to Baxter. In July of 2003, this arrangement was
          terminated, and the rights returned to XOMA. Although we are
          evaluating future options for developing this product, we do not know
          whether any options we may pursue will succeed.

     o    In January of 2001, we entered into a strategic process development
          and manufacturing alliance with Onyx to scale-up production to
          commercial volume of one of Onyx's cancer products. In June of 2003,
          Onyx notified XOMA that it was discontinuing development of the
          product and terminating the agreement so that it could focus on
          another of its anticancer compounds.

     Although we continue to evaluate additional strategic alliances and
potential partnerships, we do not know whether or when any such alliances or
partnerships will be entered into.

Because We Have No History Of Profitability And Because The Biotechnology Sector
Has Been Characterized By Highly Volatile Stock Prices, Announcements We Make
And General Market Conditions For Biotechnology Stocks Could Result In A Sudden
Change In The Value Of Our Common Shares.

     As a biopharmaceutical company, we have experienced significant volatility
in our common shares. Fluctuations in our operating results and general market
conditions for biotechnology stocks could have a significant impact on the
volatility of our common share price. From December 31, 2001 through March 12,
2004, our share price has ranged from a high of $12.19 to a low of $2.84. On
March 12, 2004, the last reported sale price of the common shares as reported on
the Nasdaq National Market was $5.85 per share. Factors contributing to such
volatility include, but are not limited to:

     o    sales and estimated or forecasted sales of products

     o    results of preclinical studies and clinical trials

     o    information relating to the safety or efficacy of our products

     o    developments regarding regulatory filings

     o    announcements of new collaborations

     o    failure to enter into collaborations

     o    developments in existing collaborations

     o    our funding requirements and the terms of our financing arrangements

     o    announcements of technological innovations or new indications for our
          therapeutic products

     o    government regulations

     o    developments in patent or other proprietary rights

     o    the number of shares outstanding



                                      -10-


     o    the number of shares trading on an average trading day

     o    announcements regarding other participants in the biotechnology and
          pharmaceutical industries and

     o    market speculation regarding any of the foregoing.

We Or Our Third Party Collaborators May Not Be Able To Increase Existing Or
Acquire New Manufacturing Capacity Sufficient To Meet Market Demand.

     Genentech is responsible for manufacturing or arranging for the
manufacturing of commercial quantities of RAPTIVA(TM). Should Genentech have
difficulty in providing manufacturing capacity to produce RAPTIVA(TM) in
sufficient quantities, we do not know whether we will be able to meet market
demand. If any of our other products are approved, because we have never
commercially introduced any pharmaceutical products, we do not know whether the
capacity of our existing manufacturing facilities can be increased to produce
sufficient quantities of our products to meet market demand. Also, if we or our
third party collaborators need additional manufacturing facilities to meet
market demand, we cannot predict that we will successfully obtain those
facilities because we do not know whether they will be available on acceptable
terms. In addition, any manufacturing facilities acquired or used to meet market
demand must meet the FDA's quality assurance guidelines.

Because We Only Recently Received Approval For Our Only Approved Product And We
Do Not And Cannot Currently Market Any Of Our Other Products For Commercial
Sale, We Do Not Know Whether There Will Be A Viable Market For Our Products.

     Even though we and Genentech recently received FDA approval to market
RAPTIVA(TM) and even if we receive regulatory approval for our other products,
our products may not be accepted in the marketplace. For example, physicians
and/or patients may not accept a product for a particular indication because it
has been biologically derived (and not discovered and developed by more
traditional means) if no biologically derived products are currently in
widespread use in that indication, as is currently the case with psoriasis.
Similarly, physicians may not accept RAPTIVA(TM) if they believe other products
to be more effective or are more comfortable prescribing other products that
have been on the market longer than RAPTIVA(TM). Consequently, we do not know if
physicians or patients will adopt or use our products for their approved
indications.

Other Companies May Render Some Or All Of Our Products Noncompetitive Or
Obsolete.

     Developments by others may render our products or technologies obsolete or
uncompetitive. Technologies developed and utilized by the biotechnology and
pharmaceutical industries are continuously and substantially changing.
Competition in the areas of genetically engineered DNA-based and antibody-based
technologies is intense and expected to increase in the future as a number of
established biotechnology firms and large chemical and pharmaceutical companies
advance in these fields. Many of these competitors may be able to develop
products and processes competitive with or superior to our own for many reasons,
including that they may have:

     o    significantly greater financial resources

     o    larger research and development and marketing staffs

     o    larger production facilities

     o    entered into arrangements with, or acquired, biotechnology companies
          to enhance their capabilities or

     o    extensive experience in preclinical testing and human clinical trials.



                                      -11-


     These factors may enable others to develop products and processes
competitive with or superior to our own or those of our collaborators. In
addition, a significant amount of research in biotechnology is being carried out
in universities and other non-profit research organizations. These entities are
becoming increasingly interested in the commercial value of their work and may
become more aggressive in seeking patent protection and licensing arrangements.

     Furthermore, positive or negative developments in connection with a
potentially competing product may have an adverse impact on our ability to raise
additional funding on acceptable terms. For example, if another product is
perceived to have a competitive advantage, or another product's failure is
perceived to increase the likelihood that our product will fail, then investors
may choose not to invest in us on terms we would accept or at all.

     Without limiting the foregoing, we are aware that:

     o    it has been announced that Amgen Inc. tested its rheumatoid arthritis
          and psoriatic arthritis drug, Enbrel(R), in a Phase III clinical trial
          in patients with moderate-to-severe plaque psoriasis, meeting the
          primary endpoint and all secondary endpoints, that the primary and key
          secondary endpoints were met in a second Phase III trial, and that a
          filing for regulatory approval with the FDA for this medication was
          submitted in July of 2003;

     o    Biogen Idec Inc. has been marketing in the U.S. since 2003 their
          product Amevive(R)to treat moderate-to-severe chronic plaque psoriasis
          in adult patients who are candidates for systemic therapy or
          phototherapy;

     o    Centocor Inc., a unit of Johnson & Johnson, has announced that it has
          tested its rheumatoid arthritis and Crohn's disease drug, Remicade(R),
          in psoriasis showing clinical benefits (and it has been announced that
          the drug has shown promising results in patients with psoriatic
          arthritis);

     o    Abbott Laboratories has presented data from a Phase II psoriasis trial
          showing clinical benefits and has announced the commencement of a
          Phase III psoriatic arthritis trial of its rheumatoid arthritis drug
          HumiraTM;

     o    MedImmune, Inc. has completed enrollment in three Phase II trials to
          evaluate its anti-T cell monoclonal antibody in psoriasis; and

     o    other companies, including Tularik Inc., are developing monoclonal
          antibody or other products for treatment of inflammatory skin
          disorders.

     A number of companies are developing monoclonal antibodies targeting
cancers, which may prove more effective than the ING-1 antibody.

     It is possible that one or more other companies may be developing one or
more products based on the same human protein as our NEUPREX(R) product, and
these product(s) may prove to be more effective than NEUPREX(R) or receive
regulatory approval prior to NEUPREX(R) or any BPI-derived product developed by
XOMA.

     Currently, there are at least two companies developing topical peptide
treatments for acne which may compete with XMP.629. Micrologix Biotech, Inc. is
developing MBI 594AN, a topical peptide that has completed a Phase IIB trial for
the treatment of acne, and Helix Biomedix, Inc. is developing several peptide
compounds.



                                      -12-


Even If We Or Our Third Party Collaborators Bring Products To Market, We May Be
Unable To Effectively Price Our Products Or Obtain Adequate Reimbursement For
Sales Of Our Products, Which Would Prevent Our Products From Becoming
Profitable.

     If we or our third party collaborators succeed in bringing our product
candidates to the market, they may not be considered cost-effective, and
reimbursement to the patient may not be available or may not be sufficient to
allow us to sell our products on a competitive basis. In both the United States
and elsewhere, sales of medical products and treatments are dependent, in part,
on the availability of reimbursement to the patient from third-party payors,
such as government and private insurance plans. Third-party payors are
increasingly challenging the prices charged for pharmaceutical products and
services. Our business is affected by the efforts of government and third-party
payors to contain or reduce the cost of health care through various means. In
the United States, there have been and will continue to be a number of federal
and state proposals to implement government controls on pricing. In addition,
the emphasis on managed care in the United States has increased and will
continue to increase the pressure on the pricing of pharmaceutical products. We
cannot predict whether any legislative or regulatory proposals will be adopted
or the effect these proposals or managed care efforts may have on our business.

If Our And Our Partners' Patent Protection For Our Principal Products And
Processes Is Not Enforceable, We May Not Realize Our Profit Potential.

     Because of the length of time and the expense associated with bringing new
products to the marketplace, we and our partners hold and are in the process of
applying for a number of patents in the United States and abroad to protect our
products and important processes and also have obtained or have the right to
obtain exclusive licenses to certain patents and applications filed by others.
However, the patent position of biotechnology companies generally is highly
uncertain and involves complex legal and factual questions, and no consistent
policy regarding the breadth of allowed claims has emerged from the actions of
the U.S. Patent and Trademark Office with respect to biotechnology patents.
Legal considerations surrounding the validity of biotechnology patents continue
to be in transition, and historical legal standards surrounding questions of
validity may not continue to be applied, and current defenses as to issued
biotechnology patents may not in fact be considered substantial in the future.
These factors have contributed to uncertainty as to:

     o    the degree and range of protection any patents will afford against
          competitors with similar technologies

     o    if and when patents will issue

     o    whether or not others will obtain patents claiming aspects similar to
          those covered by our patent applications or

     o    the extent to which we will be successful in avoiding infringement of
          any patents granted to others.

     The Patent Office has issued approximately 71 patents to us related to our
products based on human bactericidal permeability-increasing protein, which we
call BPI, including novel compositions, their manufacture, formulation, assay
and use. In addition, we are the exclusive licensee of BPI-related patents and
applications owned by New York University and Incyte Pharmaceuticals Inc. The
Patent Office has also issued nine patents to us related to our bacterial
expression technology.

     If certain patents issued to others are upheld or if certain patent
applications filed by others issue and are upheld, we may require licenses from
others in order to develop and commercialize certain potential products
incorporating our technology or we may become involved in litigation to
determine the proprietary rights of others. These licenses, if required, may not
be available on acceptable terms, and any such litigation may be costly



                                      -13-


and may have other adverse effects on our business, such as inhibiting our
ability to compete in the marketplace and absorbing significant management time.

     Due to the uncertainties regarding biotechnology patents, we also have
relied and will continue to rely upon trade secrets, know-how and continuing
technological advancement to develop and maintain our competitive position. All
of our employees have signed confidentiality agreements under which they have
agreed not to use or disclose any of our proprietary information. Research and
development contracts and relationships between us and our scientific
consultants and potential customers provide access to aspects of our know-how
that are protected generally under confidentiality agreements. These
confidentiality agreements may not be honored or may not be enforced by a court.
To the extent proprietary information is divulged to competitors or to the
public generally, such disclosure may adversely affect our ability to develop or
commercialize our products by giving others a competitive advantage or by
undermining our patent position.

Protecting Our Intellectual Property Can Be Costly And Expose Us To Risks Of
Counterclaims Against Us.

     We may be required to engage in litigation or other proceedings to protect
our intellectual property. The cost to us of this litigation, even if resolved
in our favor, could be substantial. Such litigation could also divert
management's attention and resources. In addition, if this litigation is
resolved against us, our patents may be declared invalid, and we could be held
liable for significant damages. In addition, if the litigation included a claim
of infringement by us of another party's patent that was resolved against us, we
or our collaborators may be enjoined from developing, manufacturing, selling or
importing products, processes or services without a license from the other
party.

The Financial Terms Of Some Of Our Existing Or Future Collaborative Arrangements
Could Result In Dilution Of Our Share Value.

     In November of 2003, we announced that we exercised our option to defer
payment of $40.0 million of our convertible loan from Genentech related to the
development of RAPTIVA(TM) and pay the remaining balance of approximately $29.6
million under the development loan with preference shares before year-end 2003.
These preference shares were issued in December of 2003 and are convertible into
an aggregate of 3,818,395 common shares at a conversion price of approximately
$7.75 per share, the price determined under the loan agreements at the time we
notified Genentech of our election.

     Our financing arrangement with Millennium includes a $5.0 million
convertible note we issued to Millennium in November of 2001, which comes due on
April 15, 2004 and which we intend to convert into common shares at that time.
In addition, we have the option to issue up to $14.7 million worth of common
shares, excluding the convertible debt, to Millennium through March of 2005. As
of February 28, 2004, the total amount issuable in 2004 was approximately $11.0
million. The number of shares to be issued will be based on a conversion price
to be calculated at the time of conversion. This arrangement, as well as future
arrangements we may enter into with similar effect, could result in dilution in
the value of our shares.

Because Many Of The Companies We Do Business With Are Also In The Biotechnology
Sector, The Volatility Of That Sector Can Affect Us Indirectly As Well As
Directly.

     The same factors that affect us directly because we are a biotechnology
company can also adversely impact us indirectly by affecting the ability of our
collaborators, partners and others we do business with to meet their obligations
to us or our ability to realize the value of the consideration provided to us by
these other companies. For example, in connection with our licensing
transactions relating to our bacterial expression technology, we have in the
past and may in the future agree to accept equity securities of the licensee in
payment of license fees. The future value of these or any other shares we
receive is subject both to market risks affecting our ability to realize the
value of these shares and more generally to the business and other risks to
which the issuer of these shares may be subject.



                                      -14-


As We Do More Business Internationally, We Will Be Subject To Additional
Political, Economic And Regulatory Uncertainties.

     We may not be able to successfully operate in any foreign market. We
believe that, because the pharmaceutical industry is global in nature,
international activities will be a significant part of our future business
activities and that, when and if we are able to generate income, a substantial
portion of that income will be derived from product sales and other activities
outside the United States. Foreign regulatory agencies often establish standards
different from those in the United States, and an inability to obtain foreign
regulatory approvals on a timely basis could put us at a competitive
disadvantage or make it uneconomical to proceed with a product's development.
International operations may be limited or disrupted by:

     o    imposition of government controls,

     o    export license requirements,

     o    political or economic instability,

     o    trade restrictions,

     o    changes in tariffs,

     o    restrictions on repatriating profits,

     o    exchange rate fluctuations,

     o    withholding and other taxation, and

     o    difficulties in staffing and managing international operations.

Because We Are A Relatively Small Biopharmaceutical Company With Limited
Resources, We May Not Be Able To Attract And Retain Qualified Personnel, And The
Loss Of Key Personnel Could Delay Or Prevent Achieving Our Objectives.

     Our success in developing marketable products and achieving a competitive
position will depend, in part, on our ability to attract and retain qualified
scientific and management personnel, particularly in areas requiring specific
technical, scientific or medical expertise. There is intense competition for
such personnel. Our research, product development and business efforts would be
adversely affected by the loss of one or more of key members of our scientific
or management staff, particularly our executive officers: John L. Castello, our
Chairman of the Board, President and Chief Executive Officer; Patrick J.
Scannon, M.D., Ph.D., our Senior Vice President and Chief Scientific and Medical
Officer; Clarence L. Dellio, our Senior Vice President and Chief Operating
Officer; Peter B. Davis, our Vice President, Finance and Chief Financial
Officer; and Christopher J. Margolin, our Vice President, General Counsel and
Secretary. We have employment agreements with Mr. Castello, Dr. Scannon and Mr.
Davis. We currently have no key person insurance on any of our employees.

We Are Exposed To An Increased Risk Of Product Liability Claims.

     The sale, testing and marketing of medical products entails an inherent
risk of allegations of product liability. We believe that we currently have
adequate levels of insurance for our clinical trials, however, in the event of
one or more large, unforeseen awards, such levels may not provide adequate
coverage. We will seek to obtain additional insurance, if needed, as
commercialization of RAPTIVA(TM) continues; however, because we have not yet
determined whether additional insurance is needed, we do not know whether
adequate insurance coverage will be available or be available at acceptable
costs. A significant product liability claim for which we



                                      -15-


were not covered by insurance would have to be paid from cash or other assets.
To the extent we have sufficient insurance coverage, such a claim would result
in higher subsequent insurance rates.

We May Be Subject To Increased Risks Because We Are A Bermuda Company.

     Alleged abuses by certain companies that have changed their legal domicile
from jurisdictions within the United States to Bermuda have created an
environment where, notwithstanding that we changed our legal domicile in a
transaction that was approved by our shareholders and fully taxable to our
company under U.S. law, we may be exposed to various prejudicial actions,
including:

     o    "blacklisting" of our common shares by certain pension funds;

     o    legislation restricting certain types of transactions; and

     o    punitive tax legislation.

     We do not know whether any of these things will happen, but if implemented
one or more of them may have an adverse impact on our future operations or our
share price.

If You Were To Obtain A Judgment Against Us, It May Be Difficult To Enforce
Against Us Because We Are A Foreign Entity.

     We are a Bermuda company. All or a substantial portion of our assets may be
located outside the United States. As a result, it may be difficult for
shareholders and others to enforce in United States courts judgments obtained
against us. We have irrevocably agreed that we may be served with process with
respect to actions based on offers and sales of securities made hereby in the
United States by serving Christopher J. Margolin, c/o XOMA Ltd., 2910 Seventh
Street, Berkeley, California 94710, our United States agent appointed for that
purpose. We have been advised by our Bermuda counsel, Conyers Dill & Pearman,
that there is doubt as to whether Bermuda courts would enforce judgments of
United States courts obtained in actions against XOMA or our directors and
officers that are predicated upon the civil liability provisions of the U.S.
securities laws or entertain original actions brought in Bermuda against XOMA or
such persons predicated upon the U.S. securities laws. There is no treaty in
effect between the United States and Bermuda providing for such enforcement, and
there are grounds upon which Bermuda courts may not enforce judgments of United
States courts. Certain remedies available under the United States federal
securities laws may not be allowed in Bermuda courts as contrary to that
nation's policy.

Our Shareholder Rights Agreement Or Bye-laws May Prevent Transactions That Could
Be Beneficial To Our Shareholders And May Insulate Our Management From Removal.

     In February of 2003, we adopted a new shareholder rights agreement (to
replace the shareholder rights agreement that had expired), which could make it
considerably more difficult or costly for a person or group to acquire control
of XOMA in a transaction that our board of directors opposes.

     Our bye-laws:

     o    require certain procedures to be followed and time periods to be met
          for any shareholder to propose matters to be considered at annual
          meetings of shareholders, including nominating directors for election
          at those meetings;

     o    authorize our board of directors to issue up to 1,000,000 preference
          shares with-out shareholder approval and to set the rights,
          preferences and other designations, including voting rights, of those
          shares as the board of directors may determine; and



                                      -16-


     o    contain provisions, similar to those contained in the Delaware General
          Corporation Law, that may make business combinations with interested
          shareholders more difficult.

     These provisions of our shareholders rights agreement and our bye-laws,
alone or in combination with each other, may discourage transactions involving
actual or potential changes of control, including transactions that otherwise
could involve payment of a premium over prevailing market prices to holders of
common shares, could limit the ability of shareholders to approve transactions
that they may deem to be in their best interests, and could make it considerably
more difficult for a potential acquirer to replace management.


Risks Relating To This Offering

The Actual Or Anticipated Resale By Millennium Of Our Common Shares That It
Purchases From Us Under The Investment Agreement Or Otherwise Owns Or Acquires
May Have An Adverse Impact On The Market Price Of Our Common Shares.

     The resale by Millennium through open market transactions or other means of
the common shares that it purchases from us under the investment agreement, that
we issue to Millennium upon conversion of the convertible note we have issued to
them or that it otherwise owns or acquires may, depending upon the timing of the
resales, depress the market price of our common shares. Moreover, as all the
common shares we sell to Millennium or issue upon conversion will be available
for immediate resale, the mere prospect of our sales to it could depress the
market price of our common shares. In addition, actual or anticipated downward
pressure on the market price of our common shares due to actual or anticipated
resales of our common shares by Millennium could cause some institutions or
individuals to engage in short sales of our common shares, which may itself
cause the market price of our common shares to decline.

Our Issuance Of Common Shares To Millennium Will Reduce The Percentage Equity
Ownership Of Our Existing Shareholders.

     Under our investment agreement with Millennium, we may issue to Millennium
up to $19.7 million worth of our common shares over the following 12 months on
several predetermined closing dates. The precise number of common shares that we
will issue to Millennium over the term of the investment agreement will depend
on the market price of our common shares during the period immediately preceding
the applicable closing date. Each issuance of common shares to Millennium
pursuant to the investment agreement will proportionately decrease our existing
shareholders' percentage ownership of our total outstanding equity interests.




                                      -17-




                INCORPORATION OF INFORMATION WE FILE WITH THE SEC

     The following documents filed by XOMA with the SEC pursuant to the
Securities Exchange Act are "incorporated by reference" in this prospectus,
which means we can disclose important information to you by referring you to
these documents and they are considered to be a part of this prospectus:

          (1) annual report on Form 10-K for the fiscal year ended December 31,
     2003 (file no. 0-14710);

          (2) current report on Form 8-K dated and filed on November 27, 2001,
     as amended by amendments on Form 8-K/A filed on December 13, 2001, October
     24, 2002, May 21, 2003 and February 24, 2004 respectively (file no.
     0-14710);

          (3) current report on Form 8-K dated and filed on December 18, 2003,
     as amended by amendment on Form 8-K/A filed on January 9, 2004 (file no.
     0-14710);

          (4) current report on Form 8-K dated and filed on January 6, 2004, as
     amended by amendment on Form 8-K/A filed on January 29, 2004 (file no.
     0-14710);

          (5) current report on Form 8-K dated and filed on March 1, 2004 (file
     no. 0-14710); and

          (6) the description of the common shares in the registration statement
     on Form 8-A dated and filed on April 1, 2003 under Section 12 of the
     Securities Exchange Act, including any amendment or report for the purpose
     of updating such description (file no. 0-14710).

     All documents filed by XOMA with the SEC pursuant to Section 13(a), 13(c),
14 or 15(d) of the Securities Exchange Act after the date of this prospectus and
before all of the common shares offered by this prospectus have been sold are
deemed to be incorporated by reference in, and to be part of, this prospectus
from the date any such document is filed.

     Any statements contained in a document incorporated by reference in this
prospectus are deemed to be modified or superseded for purposes of this
prospectus to the extent that a statement contained in this prospectus (or in
any other subsequently filed document which also is incorporated by reference in
this prospectus) modifies or supersedes such statement. Any statement so
modified or superseded is not deemed to constitute a part of this prospectus
except as so modified or superseded.




                                      -18-




                SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

     Some of the statements made in this prospectus are forward-looking in
nature, including those relating to the sufficiency of our cash resources and
the marketing and sales effort for RAPTIVA(TM), as well as other statements
related to current plans for product development and existing and potential
collaborative and licensing relationships, or that otherwise relate to future
periods and other statements that are not historical facts. The words "believe,"
"plan," "intend," "expect" and similar expressions are intended to identify
forward-looking statements. We caution you not to place undue reliance on these
forward-looking statements. They apply only as of the date of this prospectus
except that statements incorporated by reference from previously filed reports
apply as of the date made. The occurrence of the events described, and the
achievement of the intended results, depend on many events, some or all of which
are not predictable or not within our control. Actual results may differ
materially from those anticipated in any forward-looking statements. Many risks
and uncertainties are inherent in the biopharmaceutical industry. Others are
more specific to our business. Many of the significant risks related to our
business are described in this prospectus. These include, among others, the
period for which our cash resources are sufficient could be shortened if
expenditures are made earlier or in larger amounts than anticipated or are
unanticipated or if funds are not available on acceptable terms; and the
marketing and sales effort for RAPTIVA(TM) may not be successful due to the
strength of competition or if physicians do not adopt the product as treatment
for their patients. These and other risks, including those related to the
results of pre-clinical testing; the timing or results of pending and future
clinical trials (including the design and progress of clinical trials; safety
and efficacy of the products being tested; action, inaction or delay by the FDA,
European or other regulators or their advisory bodies; and analysis or
interpretation by, or submission to, these entities or others of scientific
data); changes in the status of existing collaborative relationships; the
ability of collaborators and other partners to meet their obligations;
competition; market demand for products; scale-up and marketing capabilities;
availability of additional licensing or collaboration opportunities;
international operations; share price volatility; our financing needs and
opportunities; uncertainties regarding the status of biotechnology patents;
uncertainties as to the costs of protecting intellectual property; and risks
associated with our status as a Bermuda company are described in more detail in
"Risk Factors." We undertake no obligation to publicly update any
forward-looking statements, regardless of any new information, future events or
other occurrences. We advise you, however, to consult any additional disclosures
we make in our reports to the SEC on Forms 10-K, 10-Q and 8-K.

                              ____________________

     We have not authorized any dealer, salesperson or other person to give you
written information other than this prospectus or to make representations as to
matters not stated in this prospectus. You must not rely on unauthorized
information. This prospectus is not an offer to sell these common shares or our
solicitation of your offer to buy the common shares in any jurisdiction where
that would not be permitted or legal. Neither the delivery of this prospectus
nor any sales made hereunder after the date of this prospectus should imply that
the information contained in this prospectus or the affairs of XOMA have not
changed since the date of this prospectus.




                                      -19-




              PRICE RANGE OF COMMON SHARES AND DIVIDEND INFORMATION

     XOMA's common shares (such common shares and the common stock of our
predecessor Delaware corporation are referred to in this prospectus as the
common shares) trade on the Nasdaq National Market under the symbol "XOMA." The
following table sets forth the quarterly range of high and low reported sale
prices of the common shares on the Nasdaq National Market for the periods
indicated (in United States dollars):

                                                    High            Low

         2002:

                      First Quarter              $12.190           $7.510
                      Second Quarter               8.510            3.000
                      Third Quarter                7.200            3.250
                      Fourth Quarter               6.250            3.800

         2003:

                      First Quarter               $4.600           $2.840
                      Second Quarter              $8.000           $3.790
                      Third Quarter              $10.700           $5.040
                      Fourth Quarter              $8.250           $5.850

         2004:

                      First Quarter
                      (through March 12)          $7.710           $5.530

     On March 12, 2004 the last reported sale price of the common shares as
reported on the Nasdaq National Market was $5.85 per share. As of March 12,
2004, there were approximately 3,066 record holders of XOMA's common shares.

     XOMA has not paid dividends on its common equity. XOMA currently does not
intend to pay dividends and intends to retain any earnings for use in its
business and the financing of its capital requirements for the foreseeable
future. The payment of any future cash dividends on XOMA's common shares will
necessarily be dependent upon the earnings and financial needs of XOMA, along
with applicable legal and contractual restrictions.




                                      -20-




                                 USE OF PROCEEDS

     We have used and intend to continue to use most of the net proceeds from
our sale of the common shares to the selling shareholder under the investment
agreement for the development of products pursuant to our collaboration
agreement with Millennium. Otherwise, we intend to use the net proceeds for
general corporate purposes, including current research and development projects,
the development of new products or technologies, equipment acquisitions, general
working capital and operating expenses.

     We have not determined the amounts we plan to spend on any of the areas
listed above or the timing of these expenditures. As a result, our management
will have broad discretion to allocate the net proceeds from our sale of the
common shares to the selling shareholders. Pending application of the net
proceeds as described above, we intend to invest the net proceeds in short-term,
investment-grade, interest-bearing securities.

     We will not receive any proceeds from the sale of the common shares by the
selling shareholder to you. To the extent shares are issued upon conversion of
the convertible note, we will benefit from the resulting cancellation of
indebtedness. The $5.0 million convertible subordinated note is convertible at
our option into our common shares.




                                      -21-




                               SELLING SHAREHOLDER

     The selling shareholder is Millennium Pharmaceuticals, Inc. On November 26,
2001, Millennium and XOMA announced an agreement in which they will collaborate
to develop two of Millennium's biotherapeutic agents for certain vascular
inflammation indications. As previously announced, under an investment
agreement, Millennium originally committed to purchase, at our option and
subject to certain conditions under the investment agreement, up to $50.0
million worth of our common shares over the 30 months following the effective
date of the investment agreement on several predetermined closing dates, through
a combination of convertible debt and equity. On December 18, 2002, Millennium
purchased approximately 1.4 million of our common shares for $7.5 million to
satisfy, in part, its obligation under the investment agreement. On May 16,
2003, we and Millennium agreed to delay the maturity of the $5.0 million
convertible subordinated note until February 26, 2004 and to adjust the timing
of Millennium's obligation to purchase the remaining $37.5 million worth of our
common shares. On June 26, 2003, Millennium purchased approximately 609,000 of
our common shares for $4.0 million to satisfy, in part, its obligation under the
investment agreement. On October 10, 2003, we announced that we discontinued
development of MLNM2201 (formerly known as LDP-01), one of the two products
being developed under our collaboration with Millennium, which had the effect of
reducing Millennium's obligation to purchase our common shares under the
investment agreement by 40% from up to $33.5 million remaining to up to $20.1
million. On November 26, 2003, Millennium purchased approximately 764,000 of our
common shares for $5.4 million to satisfy, in part, its obligation under the
investment agreement. On February 24, 2004, we and Millennium agreed to delay
the maturity of the convertible debt until April 15, 2004 (or the third business
day after the date the related registration statement is declared effective, if
later) and to further adjust the timing of Millennium's obligation to purchase
the remaining $14.7 million worth of our common shares. At each of four
subsequent closings over the following 12 months, we may issue up to $3,675,000
worth of our common shares.

     The following table sets forth certain information regarding the ownership
of common shares by the selling shareholder as of March 12, 2004, and the number
of common shares covered by this prospectus:



                                                                                                 Ownership
                                            Ownership                                         of common shares
                                         of common shares                             after the offering (assuming all
                                      prior to the offering                             shares offered are sold)(1)
                                      ----------------------                          ---------------------------------
                                                                    Number
              Name of                         Number               of Shares           Number of            Percent
        Selling Shareholder                 of Shares               Offered             Shares              of Class
------------------------------------      ------------           ------------         -----------          ------------
                                                                                                  
Millennium Pharmaceuticals, Inc. (2)      5,000,000(3)           5,000,000(4)               0                 0%




(1)  For the purposes of this filing, we have assumed that all of the shares
     included in this registration statement will be sold; however, there is no
     contractual or other arrangement requiring any of the shares to be sold.

(2)  The management of Millennium has voting and investment control over the
     common shares.

(3)  Includes shares issuable upon conversion of the entire amount of principal
     outstanding ($5.0 million), plus accrued interest, under a convertible
     subordinated note held by Millennium. Also includes common shares issuable
     to the selling shareholders, at our option and subject to certain
     conditions under the investment agreement, that we are registering for
     resale by the selling shareholders under this registration statement. We
     are registering 5,000,000 common shares based in part on our good faith
     estimate of the maximum number of common shares we have issued or may issue
     to Millennium under the investment agreement and upon conversion of the
     convertible debt.



                                      -22-


(4)  Consists of shares issuable directly to Millennium by XOMA either for cash
     pursuant to the investment agreement between the parties or upon conversion
     at maturity of or upon an event of default under the $5.0 million
     convertible subordinated note of XOMA held by Millennium.

     We are registering 5,000,000 common shares based in part on our good faith
estimate of the maximum number of common shares we have issued or may issue to
Millennium under the investment agreement and upon conversion of the convertible
debt. If the price of our common shares increases sufficiently, the number of
common shares we are registering for issuance may be higher than the number of
common shares we actually issue to Millennium under the investment agreement. In
such case, the number of shares resold by Millennium under this prospectus would
be less than the number of shares registered for resale. On the other hand, if
the price of our common shares decreases and the number of common shares we
actually issue to Millennium under the investment agreement is greater than the
number of shares we are now registering, we may need to file a new registration
statement with the Securities and Exchange Commission, which will need to become
effective prior to our completing the sales contemplated by the investment
agreement. The 5,000,000 common shares that we are registering consist of shares
issued or to be issued directly to Millennium by XOMA either for cash pursuant
to the investment agreement between the parties or upon conversion at maturity
of or upon an event of default under the $5.0 million convertible subordinated
note of XOMA held by Millennium.

     As of March 12, 2004, the selling shareholder holds none of our common
shares. Other than its obligation to purchase common shares at subsequent
closing dates under the investment agreement (at our option) and upon conversion
of the $5.0 million convertible note (at our option), the selling shareholder
has no commitments or arrangements to purchase any of our common shares.
Notwithstanding that the conversion by the selling shareholder of the $5.0
million convertible note is at our option, we have notified Millennium of our
election to convert all principal and accrued interest under the convertible
note into common shares and the selling shareholder may be deemed to be
beneficial owner of the approximately 810,000 common shares issuable upon the
conversion of the convertible note as if the convertible note had been converted
on March 16, 2004. Assuming the selling shareholder sells all of the common
shares that it has acquired or may acquire under the investment agreement and
does not otherwise acquire our common shares, it will not own any of our common
shares after its sale of the common shares to you.

Material Terms of Investment Agreement

     On November 26, 2001, Millennium and XOMA entered into an investment
agreement which committed Millennium to purchase, at our option and subject to
the conditions described in the following paragraph, up to $50.0 million worth
of our common shares over the 30 months following the effective date of the
investment agreement. Of the up to $50.0 million worth of our common shares, 5.0
million worth (and accrued interest) may be issued at our option upon conversion
of a convertible subordinated note already issued to Millennium, the entire
principal amount of which is currently outstanding. On December 18, 2002,
Millennium purchased approximately 1.4 million of our common shares for $7.5
million to satisfy, in part, its obligation under the investment agreement. On
May 16, 2003, we and Millennium agreed to delay the maturity of the $5.0 million
convertible subordinated note until February 26, 2004 and to adjust to timing of
Millennium's obligation to purchase the remaining $37.5 million worth of our
common shares. On June 26, 2003, Millennium purchased approximately 609,000 of
our common shares for $4.0 million to satisfy, in part, its obligation under the
investment agreement. On October 10, 2003, we announced that we discontinued
development of MLNM2201 (formerly known as LDP-01), one of the two products
being developed under our collaboration with Millennium, which had the effect of
reducing Millennium's obligation to purchase our common shares under the
investment agreement by 40% from up to $33.5 million remaining to up to $20.1
million. On November 26, 2003, Millennium purchased approximately 764,000 of our
common shares for $5.4 million to satisfy, in part, its obligation under the
investment agreement. On February 24, 2004, we and Millennium agreed to delay
the maturity of the convertible debt until April 15, 2004 (or the third business
day after the date the related registration statement is declared effective, if
later) and to further adjust the timing of Millennium's obligation to purchase
the remaining $14.7 million worth of our common shares. At each of four
subsequent closings over the following 12 months, we may issue up to $3,675,000
worth of our common shares. At each closing, the precise number of shares to be
purchased by Millennium will be determined using a formula based on the average
of certain sale prices per



                                      -23-


common share as reported on the Nasdaq National Market for a specified period of
time prior to the applicable closing date (subject to certain adjustments and
limitations). The formula is intended to reflect the current market price per
common share at the time of each closing, without any discount or premium.

     The obligations of Millennium to purchase the common shares that we wish to
sell at each closing will be subject to customary closing conditions, including
the delivery of legal opinions and certificates of our officers and updated
financial information, the continued listing of our common shares on the Nasdaq
National Market or the New York or American Stock Exchanges, the continued
effectiveness of the registration statement that includes this prospectus and
the continuation of our collaboration agreement with Millennium.

     We have agreed to register the resale of the common shares that we may sell
to Millennium at each closing and the common shares that we may issue to
Millennium upon conversion of the convertible debt. The registration statement
that includes this prospectus is intended to satisfy these registration
obligations.

     The 5,000,000 shares registered under the registration statement that
includes this prospectus would have represented 5.6% of our outstanding common
shares as of March 12, 2004, after giving effect to their issuance. Using the
formula set forth in the investment agreement as if the common shares were being
issued on March 16, 2004, the investment agreement gives us the option to
require the selling shareholders to purchase an aggregate of up to approximately
3.2 million common shares (assuming conversion of the convertible subordinated
note) for $19.7 million, in addition to the 2.8 million common shares already
purchased.

Conversion Provisions Of Convertible Subordinated Note

     The principal and accrued interest on the convertible subordinated note may
be converted in whole (but not in part) at our election upon maturity into our
common shares. The number of shares into which the convertible subordinated note
may be converted will be determined using a formula based on the average of
certain sale prices per common share as reported on the Nasdaq National Market
for a specified period of time prior to the conversion date (subject to certain
adjustments and limitations). The formula is intended to reflect the current
market price per common share at the time of conversion, without any discount or
premium. Using this formula as if the convertible subordinated note were being
repaid on March 16, 2004, we would be entitled to issue an aggregate of
approximately 810,000 common shares in full payment of the convertible
subordinated note.

     We have notified Millennium of our election to convert all principal and
accrued interest under the convertible note into common shares. In addition to
customary restrictions on our ability to convert, we will not be entitled to
convert any portion of the convertible subordinated note or the accrued interest
unless there is on the conversion date an effective registration statement
covering resale of all of the common shares into which the principal of the
convertible note and all accrued interest would convert. If this is not the case
at any time prior to its maturity date, then the convertible subordinated note
will remain outstanding until its maturity date. The registration statement that
includes this prospectus is intended to satisfy these registration obligations.




                                      -24-




                          DESCRIPTION OF SHARE CAPITAL

     The following statements with respect to our share capital are subject to
the detailed provisions of our memorandum of continuance and bye-laws. These
statements do not purport to be complete and, while we believe the descriptions
of the material provisions of the memorandum of continuance and bye-laws
incorporated by reference are accurate statements with respect to such material
provisions, such statements are subject to the detailed provisions in the
memorandum of continuance and bye-laws, to which reference is hereby made for a
full description of such provisions.

COMMON SHARES

General

     The memorandum of continuance and the bye-laws provide that our authorized
common share capital is limited to 135,000,000 common shares, par value
U.S.$.0005 per share. As of March 12, 2004, there were 84,306,444 common shares
outstanding.

Voting

     The holders of common shares are entitled to one vote per share. All
actions submitted to a vote of shareholders shall be voted on by the holders of
common shares, voting together as a single class (together with the Series A
preference shares (as described below), if any), except as provided by law.

Dividends

     Holders of common shares are entitled to participate, on a share for share
basis, with the holders of any other common shares outstanding, with respect to
any dividends declared by our board of directors, subject to the rights of
holders of preference shares. Dividends will generally be payable in U.S.
dollars. We have not paid cash dividends on the common shares. We currently do
not intend to pay dividends and intend to retain any of our earnings for use in
our business and the financing of our capital requirements for the foreseeable
future. The payment of any future cash dividends on the common shares is
necessarily dependent upon our earnings and financial needs, along with
applicable legal and contractual restrictions.

Liquidation

     On a liquidation of XOMA, holders of common shares will be entitled to
receive any assets remaining after the payment of our debts and the expenses of
the liquidation, subject to such special rights as may be attached to any other
class of shares.

Redemption

     The common shares are not subject to redemption either by us or the holders
thereof.

Variation of Rights

     Under our bye-laws, if at any time our share capital is divided into
different classes of shares, the rights attached to any class (unless otherwise
provided by the terms of the issue of the shares of that class) may be varied
with the consent in writing of the holders of a majority of the issued shares of
that class or with the sanction of a resolution passed by the holders of a
majority of such shares at a separate general meeting.



                                      -25-


PREFERENCE SHARES

General

     Under our memorandum of continuance and bye-laws, we have the authority to
issue 1,000,000 preference shares, par value U.S.$.05 per share. Of these,
135,000 preference shares have been designated Series A Preference Shares and
8,000 preference shares have been designated Series B Preference Shares. Under
our bye-laws, subject to the special rights attaching to any class of our shares
not being varied and to any resolution approved by the holders of 75% of the
issued shares entitled to vote in respect thereof, our board of directors may
establish one or more classes or series of preference shares having the number
of shares, designations, relative voting rights, dividend rates, liquidation and
other rights, preferences and limitations that the board of directors fixes
without any shareholder approval.

The Series A Preference Shares

     There are no Series A preference shares outstanding. Pursuant to the rights
of the Series A preference shares, subject to the rights of holders of any
shares of any series of preference shares ranking prior and superior, the
holders of Series A preference shares are entitled to receive, when, as and if
declared by our board of directors out of funds legally available for the
purpose, quarterly dividends payable in cash on the first day of March, June,
September and December in each year, commencing on the first dividend payment
date after the first issuance of a share or fraction of a share of Series A
preference shares, in an amount per share equal to the greater of (a) U.S.$1.00
or (b) 1,000 times the aggregate per share amount of all cash dividends, plus
1,000 times the aggregate per share amount of all non-cash dividends or other
distributions, other than a dividend or bonus issue payable in common shares,
declared on the common shares since the immediately preceding dividend payment
date, or, with respect to the first dividend payment date, since the first
issuance of Series A preference shares.

     In addition to any other voting rights required by law, holders of Series A
preference shares shall have the right to vote on all matters submitted to a
vote of our shareholders with each share of Series A preference shares entitled
to 1,000 votes. Except as otherwise provided by law, holders of Series A
preference shares, holders of common shares and holders of any other shares
having general voting rights shall vote together as one class on all matters
submitted to a vote of our shareholders.

     Unless otherwise provided in the rights attaching to a subsequently
designated series of our preference shares, the Series A preference shares shall
rank junior to any other series of preference shares subsequently issued as to
the payment of dividends and distribution of assets on liquidation, dissolution
or winding-up and shall rank senior to the common shares. Upon any liquidation,
dissolution or winding-up of XOMA, no distributions shall be made to holders of
shares ranking junior to the Series A preference shares unless, prior thereto,
the holders of Series A preference shares shall have received an amount equal to
accrued and unpaid dividends and distributions, whether or not declared, to the
date of such payment, plus an amount equal to the greater of (1) U.S.$100.00 per
share or (2) an aggregate amount per share equal to 1,000 times the aggregate
amount to be distributed per share to holders of common shares or to the holders
of shares ranking on parity with the Series A preference shares, except
distributions made ratably on the Series A preference shares and all other such
parity shares in proportion to the total amount to which the holders of all such
shares are entitled upon such liquidation, dissolution or winding-up.

     If we shall enter into any consolidation, amalgamation, merger, combination
or other transaction in which common shares are exchanged for or changed into
cash, other securities and/or any other property, then any Series A preference
shares outstanding shall at the same time be similarly exchanged or changed in
an amount per share equal to 1,000 times the aggregate amount of cash,
securities and/or other property, as the case may be, into which or for which
each common share is changed or exchanged.

     The Series A preference shares shall not be redeemable.



                                      -26-


The Series B Preference Shares

     8,000 Series B preference shares have been designated for issuance of which
2,959 Series B preference shares were issued upon conversion of the convertible
subordinated loans to us made by Genentech in connection with the funding of the
our development costs for RAPTIVA(TM) following the regulatory approval of
RAPTIVA(TM). Pursuant to the rights of the Series B preference shares, the
holders of Series B preference shares are not be entitled to receive any
dividends on the Series B preference shares.

     The Series B preference shares rank senior with respect to rights on
liquidation, winding-up and dissolution of XOMA to all classes of common shares.
Upon any voluntary or involuntary liquidation, dissolution or winding-up of
XOMA, holders of Series B preference shares will be entitled to receive
U.S.$10,000 per share of Series B preference shares before any distribution is
made on the common shares. The holders of Series B preference shares have no
voting rights, except as required under Bermuda law.

     The holders of Series B preference shares have the right to convert Series
B preference shares into common shares at a conversion price equal to
approximately $7.75 per common share, subject to customary anti-dilution
adjustments.

     The Series B preference shares will be automatically converted into common
shares at its then effective conversion rate immediately upon the transfer by
the initial holder to any third party which is not an affiliate of such holder.

     We will have the right, at any time and from time to time, to redeem any or
all Series B preference shares for cash in an amount equal to the conversion
price multiplied by the number of common shares into which each such share of
Series B preference shares would then be convertible.

OUTSTANDING WARRANTS

     XOMA issued 250,000 common stock purchase warrants to Incyte in July of
1998, of which 125,000 remain outstanding. Each Incyte warrant outstanding
entitles the holder thereof to purchase one common share, subject to
anti-dilution adjustments. A holder may exercise the Incyte warrants at an
exercise price of $6.00 per share on or before July 9, 2008 or earlier upon the
related license becoming fully paid up. Incyte is the holder of these warrants
and received them as part of the consideration for the grant to XOMA of an
exclusive license to all of Incyte's patent rights relating to BPI.

     XOMA issued 150,000 warrants to purchase common shares in July of 1999.
Each July 1999 warrant entitles the holder thereof to purchase one common share,
subject to anti-dilution adjustments. A holder may exercise the July 1999
warrants at an exercise price of $5.75 per share on or before July 21, 2004.
Sutro & Co. Incorporated and Arnhold and S. Bleichroeder, Inc. are the holders
of these warrants and received them as consideration for their services as
placement agents for a private placement of our common shares in July of 1999.

     XOMA issued 250,000 warrants to purchase common shares in February of 2000.
Each February 2000 warrant entitles the holder thereof to purchase one common
share, subject to anti-dilution adjustments. A holder may exercise the February
2000 warrants at an exercise price of $5.00 per share on or before February 11,
2005. Sutro & Co. Incorporated and Arnhold and S. Bleichroeder, Inc. are the
holders of these warrants and received them as consideration for their services
as placement agents for a private placement of our common shares in February of
2000.

     All of the warrants described above were issued in reliance on the
exemption from registration provided in Section 4(2) of the Securities Act. None
of the warrants described above have been registered under the Securities Act
and none may be transferred except pursuant to an effective registration
statement under the Securities Act or pursuant to an exception from registration
thereunder. Additionally, all of the warrants contain certain



                                      -27-


restrictions on their transfer. XOMA is not obligated and does not intend to
register the warrants under the Securities Act.

                              PLAN OF DISTRIBUTION

     Any or all of the common shares being offered by this prospectus may be
sold from time to time to purchasers directly by the selling shareholder or by
pledgees, donees, transferees or other successors in interest. Alternatively,
the selling shareholder may from time to time offer any or all of the common
shares through underwriters, brokers, dealers or agents who may receive
compensation in the form of underwriting discounts, concessions or commissions
from the selling shareholder and/or the purchasers of common shares for whom
they may act. The selling shareholder, and any such underwriters, brokers,
dealers or agents that participate in the distribution of common shares, are
underwriters, and any profit on the sale of the common shares by them and any
discounts, commissions or concessions received by them may be deemed to be
underwriting discounts and commissions under the Securities Act. Any such common
shares may be so offered or sold in the open market, on the Nasdaq National
Market or such other exchange or market where our common shares are then traded,
in privately negotiated transactions (subject to limitations imposed by the
investment agreement), in an underwritten offering, in block trades, to a broker
or dealer for its account in ordinary brokerage transactions, or a combination
of such methods. The selling shareholder will make such sales at market prices
prevailing at the time of sale, at prices related to such prevailing market
prices or at negotiated prices. To the extent required, the name of the selling
shareholder, the number of common shares to be sold, the purchase price, the
public offering price, the name of any agent, dealer, broker or underwriter and
any applicable commission or discount or other items constituting compensation
or indemnification arrangements with respect to a particular offering will be
set forth in an accompanying prospectus supplement. These and other matters may
also be addressed in one or more post-effective amendments to the registration
statement of which this prospectus is a part. XOMA will receive no proceeds from
the sale by the selling shareholder of the common shares offered by this
prospectus.

     In connection with distributions of the common shares, and subject to
limitations imposed by the investment agreement, the selling shareholder may
enter into option, equity forward, collar or other transactions with
broker-dealers that involve the delivery of the common shares to the
broker-dealers, which may then resell or otherwise transfer such common shares.
The selling shareholder also may loan or pledge the common shares to a
broker-dealer and the broker-dealer may sell the common shares so loaned or upon
a default may sell or otherwise transfer the pledged common shares.

     In addition, the selling shareholder and any other persons participating in
the sale or distribution of the shares offered by this prospectus will be
subject to liability under the federal securities laws and must comply with the
requirements of the Securities Act and the Securities Exchange Act, including
Rule 10b-5 and Regulation M under the Securities Exchange Act. These rules and
regulations may limit the timing of purchases and sales of our common shares by
the selling shareholder or such other persons. Under these rules and
regulations, the selling shareholder and such other persons:

     o    may not engage in any stabilization activity in connection with our
          common shares;

     o    must furnish each broker which offers our common shares covered by
          this prospectus with the number of copies of this prospectus and any
          prospectus supplement which are required by such broker; and

     o    may not bid for or purchase any of our common shares or attempt to
          induce any person to purchase any of our common shares other than as
          permitted under the Securities Exchange Act.

     These restrictions may affect the marketability of our common shares by the
selling shareholder.

     The selling shareholder has agreed, subject to certain conditions, to a
restriction on its sales in the public market based on the trading volume of our
common shares and that it will not sell shares other than in the public market
without our prior written consent.



                                      -28-


     To permit the selling shareholders to resell our common shares purchased by
it under the investment agreement, we agreed to register those shares and to
maintain that registration. We have also agreed with the selling shareholder
that, subject to limited exceptions for specified time periods, we will prepare
and file any amendments and supplements to this prospectus and the registration
statement of which it is a part as may be necessary to keep the registration
statement current and effective until:

     o    the date on which the selling shareholder may sell all of the common
          shares then held by the selling shareholder that it purchased from us
          under the investment agreement without restriction by the volume
          limitations of Rule 144(e) of the Securities Act; or

     o    the date after which all of our common shares held by the selling
          shareholder that are covered by the registration statement have been
          sold by the selling shareholder under a registration statement or
          pursuant to Rule 144.

     We have agree to indemnify and hold harmless the selling shareholder, any
broker-dealer named in the registration statement of which this prospectus is a
part and their respective controlling persons against certain liabilities,
including liabilities under the Securities Act, which may be based upon, among
other things, any untrue statement or alleged untrue statement of a material
fact contained in or incorporated by reference into the registration statement
or any omission or alleged omission to state in the registration statement or
any document incorporated by reference into the registration statement a
material fact required to be stated therein or necessary to make the statements
therein not misleading, unless made or omitted in reliance upon and in
conformity with written information provided to us by the selling shareholder or
such broker-dealer.

     All expenses incurred by XOMA in complying with the registration rights
granted to the selling shareholder pursuant to which the registration statement
to which this prospectus relates has been filed, estimated to be approximately
$127,000, will be borne by XOMA. As and when XOMA is required to update this
prospectus, it may incur additional expenses in excess of this estimated amount.

     Any common shares offered by this prospectus that qualify for sale pursuant
to Rule 144 under the Securities Act may be sold under such rule rather than
pursuant to this prospectus.

                                  LEGAL OPINION

     The validity of the common shares to which this prospectus relates has been
passed upon for XOMA by Conyers Dill & Pearman, located in Hamilton, Bermuda.

                                     EXPERTS

     The consolidated financial statements of XOMA Ltd. appearing in XOMA Ltd.'s
Annual Report (Form 10-K) for the year ended December 31, 2003, have been
audited by Ernst & Young LLP, independent auditors, as set forth in their report
thereon included therein and incorporated herein by reference. Such consolidated
financial statements are incorporated herein by reference in reliance upon such
report given on the authority of such firm as experts in accounting and
auditing.

                       WHERE YOU CAN GET MORE INFORMATION

     This prospectus is part of a registration statement that we have filed with
the SEC. The registration statement contains exhibits and other information not
included in this prospectus. At your request, we will provide you, without
charge, a copy of any documents incorporated by reference in, or included as
exhibits to, our registration statement. If you would like more information,
write or call us at:

                                    XOMA Ltd.
                               2910 Seventh Street
                               Berkeley, CA 94710
                            Telephone: (510) 204-7273



                                      -29-


     XOMA files annual, quarterly and current reports, proxy statements and
other information with the SEC. You may read and copy any reports, statements
and other information we file at the SEC's public reference room at 450 Fifth
Street, N.W., Washington D.C. 20549. You can request copies of these documents,
upon payment of a duplicating fee, by writing to the SEC. Please call the SEC at
1-800-SEC-0330 for further information on the operation of the public reference
room. XOMA's SEC filings are also available to the public on the SEC Internet
site at http://www.sec.gov.




                                      -30-



                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14. Other Expenses of Issuance and Distribution

     The estimated expenses in connection with this offering are as follows:

                                                                        Amount
                                                                      to be Paid
                                                                      ----------
SEC registration fee .............................................       $3,611
Nasdaq fee .......................................................       22,500
Legal fees and expenses (including Blue Sky fees and expenses)....       85,000
Accounting fees and expenses .....................................       15,000
Miscellaneous ....................................................          889
         Total ...................................................     $127,000

Item 15. Indemnification of Directors and Officers

     Under Bermuda law, a company is permitted to indemnify any officer or
director, out of the funds of the company, against (i) any liability incurred by
him or her in defending any proceedings, whether civil or criminal, in which
judgment is given in his or her favor, or in which he or she is acquitted, or in
connection with any application under relevant Bermuda legislation in which
relief from liability is granted to him or her by the court and (ii) any loss or
liability resulting from negligence, default, breach of duty or breach of trust,
save for his or her fraud or dishonesty.

     The bye-laws of XOMA provide for the indemnity by XOMA of the officers,
directors and employees of XOMA to the fullest extent permitted by law.

     Expenses (including attorneys' fees) incurred by an officer or director of
XOMA in defending any civil, criminal, administrative or investigative action,
suit or proceeding shall be paid by XOMA in advance of the final disposition of
such action, suit or proceeding upon receipt of an undertaking by or on behalf
of such director or officer to repay such amount if it shall ultimately be
determined that he is not entitled to be indemnified by XOMA pursuant to the
Companies Act 1981 of Bermuda.

     An officer or director of XOMA shall not be personally liable to XOMA or
its shareholders for monetary damages for any breach of fiduciary duty as a
director or officer, except to the extent that such limitation is prohibited by
the Companies Act 1981 of Bermuda.

     The indemnification and advancement of expenses and the limitation of
liability provided by the bye-laws shall not be deemed exclusive of any other
rights which any officer, director or employee, as such, may have or hereafter
acquire under the Companies Act 1981 of Bermuda, any other provision of the
bye-laws, or any agreement or otherwise. Any repeal or modification of the
aforementioned provisions of the bye-laws shall not adversely affect any right
or protection existing at the time of such repeal or modification.




                                      I-1




Item 16. Exhibits and Financial Statement Schedules

(a)  Exhibits

     Exhibit
     Number                                                           Page
     ------                                                           ----

     3.1    Memorandum of Continuance of XOMA Ltd. (Exhibit 3.4)
            (1)

     3.2    Bye-Laws of XOMA Ltd. (as amended) (Exhibit 3.2) (1)

     4.1    Shareholder Rights Agreement dated as of February 26,
            2003 by and between XOMA Ltd. and Mellon Investor
            Services LLC as Rights Agent (Exhibit 4.1) (1)

     4.2    Form of Resolution Regarding Preferences and Rights
            of Series A Preference Shares (Exhibit 4.2) (1)

     4.3    Form of Resolution Regarding Preferences and Rights
            of Series B Preference Shares (Exhibit 4.3) (2)

     4.4    Form of Common Stock Purchase Warrant (Incyte
            Warrants) (Exhibit 2) (3)

     4.5    Form of Common Share Purchase Warrant (July 1999
            Warrants) (Exhibit 4) (4)

     4.6    Form of Common Share Purchase Warrant (2000 Warrants)
            (Exhibit 4) (5)

     5.1    Opinion of Conyers Dill & Pearman

     10.1   Investment Agreement dated as of November 26, 2001 by
            and among XOMA, Millennium Pharmaceuticals, Inc. and
            mHoldings Trust (with certain confidential
            information omitted, which omitted information is the
            subject of a confidential treatment request and has
            been filed separately with the Securities and
            Exchange Commission) (Exhibit 3) (6)

     10.2   Registration Rights Agreement dated as of November
            26, 2001 by and among XOMA, Millennium
            Pharmaceuticals, Inc. and mHoldings Trust (with
            certain confidential information omitted, which
            omitted information is the subject of a confidential
            treatment request and has been filed separately with
            the Securities and Exchange Commission) (Exhibit 5)
            (7)

     10.3   Convertible Subordinated Promissory Note dated
            November 26, 2001 (with certain confidential
            information omitted, which omitted information is the
            subject of a confidential treatment request and has
            been filed separately with the Securities and
            Exchange Commission) (Exhibit 4) (7)

     10.3A  Amendment No. 1 to Convertible Subordinated
            Promissory Note dated November 5, 2002 (Exhibit
            10.3A)(8)



                                      II-2

     Exhibit
     Number                                                           Page
     ------                                                           ----

     10.4   Letter Agreement dated May 16, 2003 by and among XOMA
            Ltd., Millennium Pharmaceuticals, Inc. and mHoldings
            Trust (Exhibit 6) (9)

     10.5   Letter Agreement dated February 24, 2004 by and among
            XOMA Ltd. and Millennium Pharmaceuticals, Inc.
            (Exhibit 8) (10)

     23.1   Consent of Ernst & Young LLP, Independent Auditors

     23.3   Consent of Conyers Dill & Pearman (included in
            Exhibit 5.1)

     24.1   Power of Attorney

____________________

(1)  Incorporated by reference to the referenced exhibit to XOMA's Annual Report
     on Form 10-K for the fiscal year ended December 31, 2002 (File No.
     0-14710).

(2)  Incorporated by reference to the referenced exhibit to XOMA's Registration
     Statement on Form S-4 filed November 27, 1998, as amended (File No.
     333-68045).

(3)  Incorporated by reference to the referenced exhibit to XOMA's Current
     Report on Form 8-K dated July 9, 1998 filed July 16, 1998 (File No.
     0-14710).

(4)  Incorporated by reference to the referenced exhibit to XOMA's Current
     Report on Form 8-K dated July 23, 1999 filed July 26, 1999 (File No.
     0-14710).

(5)  Incorporated by reference to the referenced exhibit to XOMA's Current
     Report on Form 8-K dated February 11, 2000 filed February 14, 2000 (File
     No. 0-14710).

(6)  Incorporated by reference to the referenced exhibit to XOMA's Amendment No.
     2 to Current Report on Form 8-K/A dated November 26, 2001 filed on October
     24, 2002 (File No. 0-14710).

(7)  Incorporated by reference to the referenced exhibit to XOMA's Amendment No.
     1 to Current Report on Form 8-K/A dated and filed December 13, 2001 (File
     No. 0-14710).

(8)  Incorporated by reference to the referenced exhibit to XOMA's Registration
     Statement on Form S-3 filed November 6, 2002.

(9)  Incorporated by reference to the referenced exhibit to XOMA's Amendment No.
     3 to Current Report on Form 8-K/A dated November 26, 2001 filed May 21,
     2003 (File No. 0-14710).

(10) Incorporated by reference to the referenced exhibit to XOMA's Amendment No.
     4 to Current Report on Form 8-K/A dated November 26, 2001 filed February
     24, 2004 (File No. 0-14710).




                                      II-3




Item 17. Undertakings

     The undersigned registrant hereby undertakes:

          (1) To file, during any period in which offers or sales are being
     made, a post-effective amendment to this registration statement:

               (i) To include any prospectus required by Section 10(a)(3) of the
          Securities Act of 1933;

               (ii) To reflect in the prospectus any facts or events arising
          after the effective date of the registration statement (or the most
          recent post-effective amendment thereof) which, individually or in the
          aggregate, represent a fundamental change in the information set forth
          in the registration statement;

               (iii) To include any material information with respect to the
          plan of distribution not previously disclosed in the registration
          statement or any material change to such information in the
          registration statement;

     provided, however, that paragraphs (1)(i) and (1)(ii) do not apply if the
     registration statement is on Form S-3 or Form S-8, and the information
     required to be included in the post-effective amendment by those paragraphs
     is contained in periodic reports filed by the registrant pursuant to
     Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are
     incorporated by reference in the registration statement.

          (2) That, for the purpose of determining any liability under the
     Securities Act of 1933, each post-effective amendment shall be deemed to be
     a new registration statement relating to the securities offered herein, and
     the offering of such securities at that time shall be deemed to be the
     initial bona fide offering thereof.

          (3) To remove from registration by means of a post-effective amendment
     any of the securities being registered which remain unsold at the
     termination of the offering.

     The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Securities Exchange Act of 1934 that is incorporated by reference in the
registration statement shall be deemed to be a new registration statement
relating to the securities offered herein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

     Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers and controlling persons of the
registrant pursuant to the foregoing provisions, or otherwise, the registrant
has been advised that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Securities Act
of 1933 and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the registrant will, unless in
the opinion of counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Securities
Act of 1933 and will be governed by the final adjudication of such issue.



                                      II-4


     The undersigned registrant hereby undertakes to deliver or cause to be
delivered with the prospectus, to each person to whom the prospectus is sent or
given, the latest annual report to security holders that is incorporated by
reference in the prospectus and furnished pursuant to and meeting the
requirements of Rule 14a-3 or Rule 14c-3 under the Securities Exchange Act of
1934; and, where interim financial information required to be presented by
Article 3 of Regulation S-X is not set forth in the prospectus, to deliver, or
cause to be delivered to each person to whom the prospectus is sent or given,
the latest quarterly report that is specifically incorporated by reference in
the prospectus to provide such interim financial information.




                                      II-5




                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-3 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Berkeley, State of California, on March 16, 2004.


                                       XOMA LTD.



                                       By:  /s/ John L. Castello
                                           ---------------------------------
                                           Name:    John L. Castello
                                           Title:   Chairman of the Board,
                                                    President and Chief
                                                    Executive Officer



                                      II-6




                                POWER OF ATTORNEY

     KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints John L. Castello and Christopher J.
Margolin, and each of them, as his true and lawful attorneys-in-fact and agents,
with full power of substitution and resubstitution, for him and in his name,
place and stead, in any and all capacities, to sign any and all amendments
(including post-effective amendments) and supplements to this registration
statement, and to file the same, with the SEC and the Bermuda Registrar of
Companies, granting unto said attorneys-in-fact and agents, and each of them,
full power and authority to do and perform each and every act and thing
requisite and necessary to be done in connection therewith, as fully to all
intents and purposes as he might or could do in person, hereby ratifying and
confirming all that said attorneys-in-fact and agents, or any of them, or their
or his substitute or substitutes, may lawfully do or cause to be done by virtue
hereof.

     Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the dates indicated.





               Signature                                     Title                                 Date
               ---------                                     -----                                 ----

                                                                                        
                                         Chairman of the Board, President and Chief           March 16, 2004
                                         Executive Officer (Principal Executive
/s/ John L. Castello                     Officer)
--------------------------------
John L. Castello

                                         Chief Scientific and Medical Officer and             March 16, 2004
/s/ Patrick J. Scannon                   Director
--------------------------------
Patrick J. Scannon

                                         Vice President, Finance and Chief Financial          March 16, 2004
                                         Officer (Principal Financial and Accounting
/s/ Peter B. Davis                       Officer)
--------------------------------
Peter B. Davis

/s/ James G. Andress                     Director                                             March 16, 2004
--------------------------------
James G. Andress

/s/ William K. Bowes, Jr.                Director                                             March 16, 2004
--------------------------------
William K. Bowes, Jr.

/s/ Arthur Kornberg                      Director                                             March 16, 2004
--------------------------------
Arthur Kornberg

/s/ Steven C. Mendell                    Director                                             March 16, 2004
--------------------------------
Steven C. Mendell

/s/ W. Denman Van Ness                   Director                                             March 16, 2004
--------------------------------
W. Denman Van Ness

/s/ Patrick J. Zenner                    Director                                             March 16, 2004
--------------------------------
Patrick J. Zenner





                                      II-7





                                  EXHIBIT INDEX
     Exhibit
     Number                                                           Page

     3.1    Memorandum of Continuance of XOMA Ltd. (Exhibit 3.4)
            (1)

     3.2    Bye-Laws of XOMA Ltd. (as amended) (Exhibit 3.2) (1)

     4.1    Shareholder Rights Agreement dated as of February 26,
            2003 by and between XOMA Ltd. and Mellon Investor
            Services LLC as Rights Agent (Exhibit 4.1) (1)

     4.2    Form of Resolution Regarding Preferences and Rights
            of Series A Preference Shares (Exhibit 4.2) (1)

     4.3    Form of Resolution Regarding Preferences and Rights
            of Series B Preference Shares (Exhibit 4.3) (2)

     4.4    Form of Common Stock Purchase Warrant (Incyte
            Warrants) (Exhibit 2) (3)

     4.5    Form of Common Share Purchase Warrant (July 1999
            Warrants) (Exhibit 4) (4)

     4.6    Form of Common Share Purchase Warrant (2000 Warrants)
            (Exhibit 4) (5)

     5.1    Opinion of Conyers Dill & Pearman

     10.1   Investment Agreement dated as of November 26, 2001 by
            and among XOMA, Millennium Pharmaceuticals, Inc. and
            mHoldings Trust (with certain confidential
            information omitted, which omitted information is the
            subject of a confidential treatment request and has
            been filed separately with the Securities and
            Exchange Commission) (Exhibit 3) (6)

     10.2   Registration Rights Agreement dated as of November
            26, 2001 by and among XOMA, Millennium
            Pharmaceuticals, Inc. and mHoldings Trust (with
            certain confidential information omitted, which
            omitted information is the subject of a confidential
            treatment request and has been filed separately with
            the Securities and Exchange Commission) (Exhibit 5)
            (7)

     10.3   Convertible Subordinated Promissory Note dated
            November 26, 2001 (with certain confidential
            information omitted, which omitted information is the
            subject of a confidential treatment request and has
            been filed separately with the Securities and
            Exchange Commission) (Exhibit 4) (7)

     10.3A  Amendment No. 1 to Convertible Subordinated
            Promissory Note dated November 5, 2002 (Exhibit
            10.3A)(8)





     10.4   Letter Agreement dated May 16, 2003 by and among XOMA
            Ltd., Millennium Pharmaceuticals, Inc. and mHoldings
            Trust (Exhibit 6) (9)

     10.5   Letter Agreement dated February 24, 2004 by and among
            XOMA Ltd. and Millennium Pharmaceuticals, Inc.
            (Exhibit 8) (10)

     23.1   Consent of Ernst & Young LLP, Independent Auditors

     23.3   Consent of Conyers Dill & Pearman (included in
            Exhibit 5.1)

     24.1   Power of Attorney

____________________

(1)  Incorporated by reference tot he referenced exhibit to XOMA's Annual Report
     on Form 10-K for the fiscal year ended December 31, 2002 (File No.
     0-14710).

(2)  Incorporated by reference to the referenced exhibit to XOMA's Registration
     Statement on Form S-4 filed November 27, 1998, as amended (File No.
     333-68045).

(3)  Incorporated by reference to the referenced exhibit to XOMA's Current
     Report on Form 8-K dated July 9, 1998 filed July 16, 1998 (File No.
     0-14710).

(4)  Incorporated by reference to the referenced exhibit to XOMA's Current
     Report on Form 8-K dated July 23, 1999 filed July 26, 1999 (File No.
     0-14710).

(5)  Incorporated by reference to the referenced exhibit to XOMA's Current
     Report on Form 8-K dated February 11, 2000 filed February 14, 2000 (File
     No. 0-14710).

(6)  Incorporated by reference to the referenced exhibit to XOMA's Amendment No.
     2 to Current Report on Form 8-K/A dated November 26, 2001 filed October 24,
     2002 (File No. 0-14710).

(7)  Incorporated by reference to the referenced exhibit to XOMA's Amendment No.
     1 to Current Report on Form 8-K/A dated and filed December 13, 2001 (File
     No. 0-14710).

(8)  Incorporated by reference to the referenced exhibit to XOMA's Registration
     Statement on Form S-3 filed November 6, 2002.

(9)  Incorporated by reference to the referenced exhibit to XOMA's Amendment No.
     3 to Current Report on Form 8-K/A dated November 26, 2001 filed May 21,
     2003 (File No. 0-14710).

(10) Incorporated by reference to the referenced exhibit to XOMA's Amendment No.
     4 to Current Report on Form 8-K/A dated November 26, 2001 filed February
     24, 2004 (File No. 0-14710).


                                      -2-



                                                                     EXHIBIT 5.1




                     [Letterhead of Conyers Dill & Pearman]


                                                                   16 March 2004


XOMA Ltd.
2910 Seventh Street
Berkeley, California  94710
USA



Dear Sirs

XOMA Ltd. (the "Company")

We have acted as special legal counsel in Bermuda to the Company in connection
with the Registration Statement on Form S-3 (the "Registration Statement", which
term does not include any other instrument or agreement whether or not
specifically referred to therein or attached as an exhibit or schedule thereto)
filed with the U.S. Securities and Exchange Commission (the "Commission") on 16
March 2004 relating to the registration under the U.S. Securities Act of 1933,
as amended, of an aggregate of 5,000,000 common shares par value US$.0005 per
share (the "Common Shares"), including $5.0 million worth of common shares
issuable upon the conversion of the convertible subordinated promissory note
issued by the Company pursuant to the Investment Agreement (as defined below).

For the purposes of giving this opinion, we have examined the following
documents:

(i)  a facsimile copy of an Investment Agreement (the "Investment Agreement",
     which term does not include any other instrument or agreement whether or
     not specifically referred to therein or attached as an exhibit or schedule
     thereto) dated as of 26 November 2001 between the Company and Millennium
     Pharmaceuticals, Inc.;

(ii) a facsimile copy of a Convertible Subordinated Promissory Note (the "Note",
     which term does not include any other instrument or agreement whether or
     not specifically referred to therein or attached as an exhibit or schedule
     thereto) dated as of 26 November 2001 by the Company;

(iii) a facsimile copy of an Amendment No. 1 to Convertible Subordinated
     Promissory Note (the "Amendment") dated as of 5 November 2002 between the
     Company, mHoldings Trust and Millennium Pharmaceuticals, Inc.;

(iv) a facsimile copy of a Letter Agreement dated 16 May 2003 between the
     Company, Millennium Pharmaceuticals, Inc. and mHoldings Trust; and

(v)  a facsimile copy of a Letter Agreement dated 24 February 2004 between the
     Company and Millennium Pharmaceuticals, Inc.





The documents listed in items (i) through (v) above are herein sometimes
collectively referred to as the "Documents" (which term does not include any
other instrument or agreement whether or not specifically referred to therein or
attached as an exhibit or schedule thereto).

We have also reviewed the memorandum of continuance and the bye-laws of the
Company, each certified by the Secretary of the Company on 15 March 2004,
extracts of minutes of a meeting of its shareholders held on 31 January 2000, of
meetings of its directors held on 1 November 2001, 30 October 2002, 21 May 2003
and 25 February 2004 (in draft) and of a meeting of the pricing committee of its
board of directors held on 5 November 2002, certified by the Secretary of the
Company on 15 March 2004 (together, the "Minutes") and such other documents and
made such enquiries as to questions of law as we have deemed necessary in order
to render the opinion set forth below.

We have assumed (a) the genuineness and authenticity of all signatures and the
conformity to the originals of all copies (whether or not certified) examined by
us and the authenticity and completeness of the originals from which such copies
were taken, (b) the capacity, power and authority of each of the parties to the
Documents, other than the Company, to enter into and perform its respective
obligations under the Documents, (c) the due execution and delivery of the
Documents by each of the parties thereto, except the Company, (d) the accuracy
and completeness of all factual representations made in the Documents and other
documents reviewed by us, (e) that the resolutions contained in the Minutes
remain in full force and effect and have not been rescinded or amended, (f) that
the Company is entering into the Documents pursuant to its business of medical
research, (g) that there are reasonable grounds for believing that prior to and
immediately following the Company's entering into each of the Documents, the
Company is and will be able to pay its liabilities as they fall due, (h) that
there is no provision of the law of any jurisdiction, other than Bermuda, which
would have any implication in relation to the opinions expressed herein, (i) the
validity and binding effect under the laws of the State of New York of the
Documents in accordance with their respective terms, (j) that none of the
parties to the Documents has carried on or will carry on activities, other than
the performance of its obligations under the Documents, which would constitute
the carrying on of investment business in or from Bermuda and that none of the
parties to the Documents, other than the Company, will perform its obligations
under the Documents in or from Bermuda, (k) that the Note will be issued and
paid for in accordance with the Documents, (l) that the Company is at all
materials times listed on National Association of Securities Dealers Automatic
Quotation System (NASDAQ), and (m) that the draft extract of the meeting of the
Company's directors held on 25 February 2004 which was certified by the
Secretary of the Company is accurate in all material respects.

We express no opinion as to the enforceability of any provision of the Documents
which provides for the payment of a specified rate of interest on the amount of
a judgment after the date of judgment or which purports to fetter the statutory
powers of the Company.

We have made no investigation of and express no opinion in relation to the laws
of any jurisdiction other than Bermuda. This opinion is to be governed by and
construed in accordance with the laws of Bermuda and is limited to and is given
on the basis of the current law and practice in Bermuda. This opinion is issued
solely for the purpose set out above and is not to be relied upon in respect of
any other matter.

On the basis of and subject to the foregoing, we are of the opinion that:

1.   The Common Shares have been duly authorised in accordance with the
     Company's memorandum of continuance and bye-laws.

2.   When issued and paid for in accordance with the terms of the Investment
     Agreement and the Note, as applicable, the Common Shares will be validly
     issued, fully paid and non-assessable (meaning that no further sums are
     required to be paid by the holders thereof in connection with the issue of
     such shares).



                                       -2-


We hereby consent to the filing of this opinion as an exhibit to the
Registration Statement and to the reference to our firm under the headings "Risk
Factors" and "Legal Opinion" in the Registration Statement.

Yours faithfully

CONYERS DILL & PEARMAN

/s/ CONYERS DILL & PEARMAN




                                      -3-



                                                                    EXHIBIT 23.1

               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS


We consent to the reference to our firm under the caption "Experts" in the
Registration Statement (Form S-3) and related Prospectus of XOMA Ltd. for the
registration of 5,000,000 of its common shares and to the incorporation by
reference therein of our report dated February 6, 2004, except for Note 12, as
to which the date is February 27, 2004, with respect to the consolidated
financial statements of XOMA Ltd. included in its Annual Report (Form 10-K) for
the year ended December 31, 2003, filed with the Securities and Exchange
Commission.


                                                           /S/ ERNST & YOUNG LLP


Palo Alto, California
March 10, 2004