Despite the White House voicing its opposition against Israel striking back at Iran, the Jewish state issued "limited" strikes early Friday.
Fox News Digital has confirmed there have been explosions in Isfahan province where Natanz is located, though it is not clear whether it has been hit.
A well-placed military source has told Fox that the strike was "limited."
The news came after President Joe Biden warned Prime Minister Benjamin Netanyahu that the U.S. would not take part in a counter-offensive against Iran.
ISRAEL STRIKES SITE IN IRAN IN RETALIATION FOR WEEKEND ASSAULT: SOURCE
John Kirby, the White House's top national security spokesperson, told ABC's "This Week" program on Sunday, April 14 that the United States will continue to help Israel defend itself, but does not want war with Iran.
Kirby said "our commitment is ironclad" to defending Israel and to "helping Israel defend itself," after being asked if the U.S. would support retaliation.
Kirby doubled-down on the fact that Biden does not "seek" war with Iran.
"And as the president has said many times, we don't seek a wider war in the region. We don't seek a war with Iran. And I think I will leave it at that," Kirby added.
ISRAEL'S ADVANCED MILITARY TECHNOLOGY ON FULL DISPLAY DURING IRAN'S ATTACK
"We don't seek escalated tensions in the region. We don't seek a wider conflict," Kirby said.
Pentagon Press Secretary Major General Pat Ryder echoed Kirby's sentiments, sharing in a press briefing that the U.S. does "not want to see a wider regional war."
"As I've highlighted, we do not seek escalation in the region, but we will not hesitate to defend Israel and protect our personnel," he said during the question and answer segment of the briefing.
"Again, we do not want to see a wider regional war," he added. "We don't seek conflict with Iran, but we won't hesitate to take [the] necessary actions to protect our forces."
Reports of Israel's "limited strike" against Iran came following a retaliatory strike over the weekend.
Iran attacked Israel over the weekend in retaliation for Israel's deadly strike on Iran's consulate in Syria earlier this month that killed a dozen people, including a top general.
The weekend attack by Iran marked a major escalation of violence. Despite decades of hostilities between the two nations, Iran has never directly attacked Israel, instead relying on proxy forces in Iraq, Lebanon and elsewhere.
Fox News' Bradford Betz and Jennifer Griffin contributed to this report.
