Recently, BOC Sciences announced that it will provide pseudouridine and its derivatives required for the manufacture of mRNA vaccines.
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Recently, BOC Sciences, a New York-based supplier of pharmaceutical raw materials, announced that it will provide pseudouridine and its derivatives required for the manufacture of mRNA vaccines to prevent infection by a variety of pathogens.
The development of preventive vaccines against infectious pathogens is the key to controlling and preventing large-scale outbreaks of epidemics. Vaccines currently on the market include inactivated vaccines, live attenuated vaccines, subunit vaccines, etc. These traditional vaccines have played an important role in the prevention of many diseases. However, in the face of acute outbreaks of infectious diseases such as COVID-19, the development and production cycle of traditional vaccines is too long to meet the needs of epidemic control. Compared with these traditional vaccines, mRNA vaccines have the advantages of safety, high efficiency, and convenient production. The mRNA vaccine can be successfully used to prevent the infection of a variety of pathogens, such as HIV, influenza virus, COVID-19, etc., and has great potential for development. The pharmacological properties of mRNA give it an unparalleled advantage in the field of vaccine therapy.
An important challenge in the development of mRNA vaccines is their immunogenicity, because foreign RNA will be regarded as a signal of viral infection. When the mRNA vaccine is injected into the body, it will cause a series of immune responses, just like the body is fighting against the invasion of a virus. The chemically modified mRNA can be exempt from immunoassay. The modified nucleoside is more like an endogenous substance in the cell, thereby reducing its inherent immunogenicity. Therefore, cells can distinguish pathological or invasive mRNA. In the development of mRNA vaccines, pseudouridine (Ψ) is one of the main chemical modification methods. The human body's immune response to mRNA vaccines is mainly related to uridine. Using pseudouridine and its derivatives to replace uridine can reduce the immune system's recognition of mRNA, thereby improving the safety of mRNA vaccines. In addition, the enzymatic reaction in the process of producing mRNA vaccines will generate double-stranded RNA by-products, resulting in a stress response, and ultimately leading to mRNA translation inhibition and degradation. The modified nucleosides can enhance the stability and translation ability of mRNA.
For more information about pseudouridine and its derivatives, please visit the website of BOC Sciences: https://www.bocsci.com/pseudouridine-and-its-derivatives.html.
About BOC Sciences
BOC Sciences has excellent experts specializing in research in life sciences, drug discovery, chemistry and other fields, and is a reliable supplier of comprehensive chemicals for researchers in academia and industry. Since the establishment of the company, the quality of its products (such as small molecule inhibitors, natural compounds, nucleosides and nucleotides) has been recognized by scientists and researchers all over the world. In addition, it provides a wide range of services to support all stages of drug discovery.
Contact Info:
Name: Alex Brown
Email: Send Email
Organization: BOC Sciences
Website: https://www.bocsci.com
Source: MarketersMedia
Release ID: 89022381
