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Modified PseudoUridines Open up Limitless Possibilities for COVID-19 mRNA Vaccines

According to the latest market report, BOC Sciences, with the yearly output of pseudoUridines and 1-methylpseudoUridines exceeding 500 kg and 1000 kg respectively, now grows to be the largest supplier around the world. What do such data stand for in the tough times overwhelmed by COVID-19? An article entitled The Critical Contribution of PseudoUridine to mRNA COVID-19 Vaccines has specified some background information.

This article argues that the presence of a critical RNA modification (N1-methyl-pseudoUridine) in mRNA vaccines can bring striking improvements in efficacy. For instance, the Pfizer-BioNTech and Moderna’s mRNA vaccines consisting of N1-methyl-pseudoUridine-modified mRNA encoding the SARS-COVID-19 spike protein and delivered with a lipid nanoparticle (LNP) formulation present efficacy higher than 90%.

There is an extensive list of pseudoUridines and derivatives in BOC Sciences' product inventory, embracing both naturally occurring and chemically synthesized ones.

Four pseudoUridine derivatives are discovered in natural RNA modification, including 1-methylpseudoUridine, 3-methylpseudoUridine, 2′-O-methylpseudoUridine, and a hypermodified residue 1-methyl-3-(3-amino-3-carboxypropyl) pseudoUridine. "Thankfully, we are in a position to manufacture all of them based on the thorough experimental and theoretical investigation into pseudoUridine structures," the technical advisor of BOC Sciences said. In addition, BOC Sciences is also equipped with versatile chemical synthesis technologies that make more derivatizations of pseudoUridine a reality. Its expertise in this field involves not only the previously reported four modified pseudoUridines but also other novel ones that have been in urgent demand during the outbreak.

BOC Sciences' bulk and quality production of pseudoUridines is a significant part of the COVID-19 campaign since it greatly eases the current pressing raw material supply issue for mRNA vaccine R&D. "Well, of course, we know how important pseudoUridines are in our vaccine development program. However, the procurement department was previously in trouble outsourcing raw materials owing to the pressure facing global factories and logistics," a regular customer of BOC Sciences remarked, "This problem of uncertainty in the supply chain was not resolved until we got connected with BOC Sciences who has the potent production capacity and impeccable project management system."

BOC Sciences is actively expanding its partnerships with a broader scope of customers, holding the vision that mRNA vaccine developers can be emancipated from the upstream supply worries and ultimately power up the fight against the epidemic.


BOC Sciences has become the largest supplier of pseudoUridines in the world with a significant production capacity. Currently, it actively gets engaged in the anti-epidemic campaign and is widely acclaimed for its unique contribution.

Contact Info:
Name: Alex Brown
Email: Send Email
Organization: BOC Sciences
Address: New York, USA
Phone: 1-631-485-4226

Release ID: 89079447

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